A Promising Biomimetic Hydrogen Sulfide System for Advancing Inflammatory Disease Treatment
Abstract
Abstract Hydrogen sulfide (H 2 S) exhibits a Janus‐faced nature in the regulation of inflammatory diseases, acting as both a therapeutic agent and a pathological aggravator. Effectively harnessing its beneficial effects while mitigating its harmful impacts is pivotal for advancing H 2 S‐based therapies. Here, an innovative H 2 S supply system is introduced that enables H 2 S to primarily exhibit its therapeutic effects. Unlike conventional synthetic H 2 S donor‐based strategies, a biomimetic H 2 S supply system (termed CP) is presented that mimics endogenous enzymatic H 2 S production. The CP sustainably produces H 2 S at a constant rate throughout the dosing period, ensuring therapeutic benefits while avoiding toxicity. Furthermore, by functionalizing CP with hyaluronic acid, the resulting system (CPH) not only achieves targeted delivery to inflammatory bowel disease (IBD) tissues but also provides controllable H 2 S production within the diseased microenvironment. Consequently, CPH significantly mitigates immune inflammation, promotes intestinal epithelial barrier repair, and modulates gut microbiota by sustainably and constantly supplying the multifunctional H 2 S. This study revolutionizes the H 2 S supply strategies and provides new insights into gas‐based therapies.
Article Details
Authors (12)
Chaoqiang Qiao
Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology
Lexuan Wang
Engineering Research Center of Molecular & Neuroimaging Ministry of Education School of Life Science and Technology Xidian University Xi'an 710126 P. R. China
Ruili Zhang
Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology
Yichenxi Shi
Engineering Research Center of Molecular & Neuroimaging Ministry of Education School of Life Science and Technology Xidian University Xi'an 710126 P. R. China
Chuting Huang
School of Physics & Electronics, Henan University 1 , Kaifeng 475004,
Yu Ji
Zuo Yang
Department of Laboratory Medicine Zhongnan Hospital of Wuhan University Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education) Hubei Key Lab on Organic and Polymeric OptoElectronic Materials College of Chemistry and Molecular Sciences The Institute for Advanced Studies and TaiKang Center for Life and Medical Sciences Wuhan University Wuhan 430072 China
Yanbin Feng
Lab of Molecular Imaging and Translational Medicine (MITM) Engineering Research Center of Molecular & Neuroimaging Ministry of Education School of Life Science and Technology Xidian University Xi'an Shaanxi 710126 China
Zhuang Chen
Lab of Molecular Imaging and Translational Medicine (MITM), Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University & International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment, 266 Xinglong Section of Xifeng Road, Xi’an, Shaanxi 710126, P. R. China
Jia Liu
Peng Yang
Zhongliang Wang
Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology