Cardiac Organoid Model Inspired Micro‐Robot Smart Patch to Treat Myocardial Infarction
Abstract
Abstract Post‐myocardial infarction (MI), the rapid decrease in pH triggers myocardial cell acidosis, which compromises the therapeutic efficacy of exosomes in MI. The groundbreaking research in the human cardiac organoid MI model suggests that exosomes, when paired with pH adjustment, dramatically reduce cardiomyocyte mortality while maintaining their proliferative potential, underscoring the importance of pH regulation in myocardial preservation. Micro‐robot mounted micro‐needle (MN) patch is thus proposed, targeting MI‐acidic microenvironmet, to deliver exosomes into deep injured tissue. Upon injection, the patch base releases VEGF‐laden nanoparticles adhering to the infarcted myocardium. The smart patch is found not only 3D reconstructs the vascular network in MI regions but also effectively saves cardiomyocytes in rats. Furthermore, the minimally invasive delivery of MN patches are also verified to hearts of rabbits and pigs via thoracoscopic surgery underscores. These findings suggest that precise regulation of the microenvironment is a key to improving treatment outcomes.
Article Details
Authors (13)
Fangfang Wang
Zilu Xu
Department of Anatomy Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing Key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University Chongqing 400038 China
Feiyang Zheng
Dongcheng Yang
Department of Anatomy Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing Engineering Research Center of Ministry of Education for Tissue and Organ Regeneration and Manufacturing Army Medical University Chongqing 400038 China
Kaige Xu
School of Medicine & Nursing and First Affiliated Hospital Huzhou University Huzhou 313000 China
Ming Ke
Department of Anatomy Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing Key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University Chongqing 400038 China
Xiao Zhou
Xiaohan Zhang
Department of Otolaryngology, Shandong Provincial Hospital, Medical Science and Technology Innovation Center, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences
Ju Tan
Department of Anatomy Third Military Medical University Chongqing 400038 P. R. China
Yong Liu
Yansha Hao
Engineering Research Center of Ministry of Education for Tissue and Organ Regeneration and Manufacturing Chongqing 400038 China
Malcolm Xing
Chuhong Zhu
School of Materials Science and Engineering Anhui University Hefei P.R. China