Combinatorial Assembly of Biomimetic Janus Membrane with Multiscale Architectures for Guided Bone Regeneration
Abstract
ABSTRACT Guided bone regeneration (GBR) has gained significant attention in the field of bone tissue engineering. However, designing an effective barrier membrane that simultaneously meets the mechanical and biological requirements at the soft–hard tissue interface remains a considerable challenge. Herein, we introduce a combinatorial assembly strategy to construct a continuous Janus membrane with multiscale architectural features inspired by biological materials. Structurally, the membrane features an asymmetric design, comprising a compact layer with a Bouligand architecture that incorporates amorphous calcium phosphate (ACP) to enhance mechanical strength and prevent soft tissue infiltration, and a porous layer that recapitulates the trabecular structure of cancellous bone, enriched with hydroxyapatite (HAp) crystals to promote cellular adhesion and osteoinduction. Subsequent in vitro and in vivo results show that the membrane not only exhibits excellent biocompatibility and barrier function but also significantly enhances osteogenic differentiation and bone regeneration in a cranial defect model. This work demonstrates that integrating diverse fabrication techniques enables the creation of functionally efficient GBR membranes with hierarchical structures, offering a promising pathway toward multifunctional regenerative materials.
Article Details
Authors (7)
Yi‐Yuan Li
Department of Oral Implantology & Department of Oral and Maxillofacial Surgery Stomatological Hospital and Dental School of Tongji University Shanghai Engineering Research Center of Tooth Restoration and Regeneration Shanghai China
Li‐Bo Mao
New Cornerstone Science Laboratory Department of Chemistry Institute of Biomimetic Materials & Chemistry Anhui Engineering Laboratory of Biomimetic Materials Division of Nanomaterials & Chemistry Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Hefei China
Yan‐Hui‐Zhi Feng
Department of Oral Implantology & Department of Oral and Maxillofacial Surgery Stomatological Hospital and Dental School of Tongji University Shanghai Engineering Research Center of Tooth Restoration and Regeneration Shanghai China
Hai‐Cheng Wang
Department of Oral Implantology & Department of Oral and Maxillofacial Surgery Stomatological Hospital and Dental School of Tongji University Shanghai Engineering Research Center of Tooth Restoration and Regeneration Shanghai China
Yu‐Feng Meng
New Cornerstone Science Laboratory Department of Chemistry Institute of Biomimetic Materials & Chemistry Anhui Engineering Laboratory of Biomimetic Materials Division of Nanomaterials & Chemistry Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Hefei China
Shu‐Hong Yu
New Cornerstone Science Laboratory Department of Chemistry Institute of Biomimetic Materials and Chemistry Anhui Engineering Laboratory of Biomimetic Materials Division of Nanomaterials and Chemistry Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Hefei 230026 China
Zuo‐Lin Wang
Department of Oral Implantology & Department of Oral and Maxillofacial Surgery Stomatological Hospital and Dental School of Tongji University Shanghai Engineering Research Center of Tooth Restoration and Regeneration Shanghai China