De Novo Design of Efficient NIR‐II‐Activated Heavy‐Atom‐Free Type‐I Photosensitizer for Anti‐Tumor Photoimmunotherapy
Abstract
AbstractType‐I photosensitizers (PSs) are considered to be efficient agents for overcoming the oxygen‐dependent deficiency of traditional photodynamic therapy (PDT). However, it is still challenging to design type‐I PSs that can be activated by the second near‐infrared (NIR‐II) irradiation. Herein, a series of organic heavy‐atom‐free molecules are designed (named as CTU1, CTU2, and CTU3) and exhibit strong absorption bands over the first near‐infrared and NIR‐II regions. Among them, water‐dispersible CTU3 nanoparticles (NPs) show strong J‐aggregate characteristics and a good NIR‐II absorption band, resulting in highly efficient •O2− generation upon irradiation of 1064 nm light. In addition, the CTU3 NPs also exhibit a high photothermal conversion efficiency of 88.6%. In vitro and in vivo experiments show that CTU3 NPs have superior PDT and photothermal therapy (PTT) effects, which can further induce immunogenic cell death and activate immune cells in 4T1 tumor‐bearing mice for combined PDT/PTT anti‐tumor photoimmunotherapy against refractory tumors. This work presents a paradigm of de novo design of NIR‐II light‐activated type‐I PS for combinational photoimmunotherapy of cancer.
Article Details
Authors (17)
Huan Chen
Yu Wang
Zhangxin He
Yingpeng Wan
College of Pharmaceutical Sciences Soochow University Suzhou 215123 P. R. China
Chen Cao
Key Laboratory of Advanced Catalysis, Gansu Province; State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering
Ziwei Lu
College of Pharmaceutical Sciences Soochow University Suzhou 215123 P. R. China
Yijian Gao
College of Pharmaceutical Sciences, The Fourth Affiliated Hospital of Soochow University, Suzhou Medical College
Xiao Cui
Ka‐Wai Lee
Center of Super‐Diamond and Advanced Films (COSDAF) Department of Chemistry City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong SAR P. R. China
Ji‐Hua Tan
School of Chemical Engineering and Light Industry Guangdong University of Technology Guangzhou P. R. China
Wenchang Xu
College of Pharmaceutical Sciences, The Fourth Affiliated Hospital of Soochow University, Suzhou Medical College
Yuliang Yang
College of Pharmaceutical Sciences, The Fourth Affiliated Hospital of Soochow University, Suzhou Medical College
Xiliang Li
College of Pharmaceutical Sciences The Fourth Affiliated Hospital of Soochow University, Suzhou Medical College, Soochow University Suzhou P.R. China
Yali Wang
The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
Jianquan Hou
Shengliang Li
College of Pharmaceutical Sciences
Chun‐Sing Lee
Department of Chemistry City University of Hong Kong Kowloon Hong Kong SAR P. R. China