Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Living Guideline, Version 2026.1.2

M Manish A. Shah (Weill Cornell Medicine, New York, NY) J Jacob S. Marzalik (JSM Research Services, LLC, Arlington, VA) E Erin B. Kennedy (American Society of Clinical Oncology, Alexandria, VA) D Dana Deighton (Melanoma Research Alliance, Washington, DC) Z Zahra Hamedi (Chao Family Comprehensive Cancer Center, University of California-Irvine Medical Center, Irvine, CA) M Minaxi Jhawer (Englewood Health, Englewood, NJ) K Kunal C. Kadakia (Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Charlotte, NC) P Paola Montenegro S Sarbajit Mukherjee (Department of Medicine, Roswell Park Comprehensive Cancer Center , Buffalo, NY,) C Christopher Nevala-Plagemann (University of Utah Huntsman Cancer Center, Salt Lake City, UT) A Anwaar Saeed B Bryan J. Schneider (University of Michigan Health, Ann Arbor, MI) T Thomas Semrad (Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee, CA) K Kohei Shitara M Melani Vincelli (Debbie’s Dream Foundation, Plantation, FL) L Lakshmi Rajdev (Icahn School of Medicine, Mount Sinai, New York, NY)

Abstract

This guideline has been updated. This ASCO Living Guideline is reviewed on an eight-week cycle. Please see the online dynamic version for the latest updates. Living guidelines are developed for selected topic areas with rapidly evolving evidence that drives frequent change in recommended clinical practice. Living guidelines are updated on a regular schedule by a standing expert panel that systematically reviews the health literature on a continuous basis, as described in the ASCO Guidelines Methodology Manual . ASCO Living Guidelines follow the ASCO Conflict of Interest Policy Implementation for Clinical Practice Guidelines . Living Guidelines and updates are not intended to substitute for independent professional judgment of the treating clinician and do not account for individual variation among patients. See appendix for disclaimers and other important information (Appendix I and Appendix II). Updates are published regularly and can be found on the ASCO Publications website .

Article Details

Volume / Issue Vol. 1, Issue 1
Published August 17, 2026
ISSN 0732-183X
Publisher Lippincott Williams & Wilkins

Journal Info

Journal of Clinical Oncology

Lippincott Williams & Wilkins

ISSN: 0732-183X Health Sciences

Authors (16)

M

Manish A. Shah

Weill Cornell Medicine, New York, NY

J

Jacob S. Marzalik

JSM Research Services, LLC, Arlington, VA

E

Erin B. Kennedy

American Society of Clinical Oncology, Alexandria, VA

D

Dana Deighton

Melanoma Research Alliance, Washington, DC

Z

Zahra Hamedi

Chao Family Comprehensive Cancer Center, University of California-Irvine Medical Center, Irvine, CA

M

Minaxi Jhawer

Englewood Health, Englewood, NJ

K

Kunal C. Kadakia

Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Charlotte, NC

P

Paola Montenegro

S

Sarbajit Mukherjee

Department of Medicine, Roswell Park Comprehensive Cancer Center , Buffalo, NY,

C

Christopher Nevala-Plagemann

University of Utah Huntsman Cancer Center, Salt Lake City, UT

A

Anwaar Saeed

B

Bryan J. Schneider

University of Michigan Health, Ann Arbor, MI

T

Thomas Semrad

Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee, CA

K

Kohei Shitara

M

Melani Vincelli

Debbie’s Dream Foundation, Plantation, FL

L

Lakshmi Rajdev

Icahn School of Medicine, Mount Sinai, New York, NY