Interfacial Super‐Assembled Hetero‐Structured Chiral Nanochannels for Enantioseparation Applications

Abstract

ABSTRACT Chirality is a fundamental property with profound implications in fields like pharmaceuticals, yet the separation of enantiomers remains a significant technical hurdle. This review chronicles the development of interfacial super‐assembled hetero‐structured chiral nanochannel membranes, a transformative approach for enantioseparation. We begin by systematically summarizing the construction of these hierarchical membranes from zero‐ to three‐dimensional building blocks, employing a versatile toolbox of interfacial assembly strategies including phase inversion, electrospinning, and vacuum filtration. The design principles of pore‐in‐pore, pore‐on‐pore, and multichannel configurations are detailed, demonstrating how they break the conventional permeability‐selectivity trade‐off. The core transport mechanisms including diffusion‐selective, adsorption‐selective, and the recently proposed couple‐accelerated‐selective transport are elucidated. The review also surveys representative material systems, from metal‐organic frameworks (MOF) to molecularly imprinted polymers (MIP). We conclude with a forward‐looking perspective on persistent challenges, such as scalability and stability, and the immense opportunities presented by artifacial intelligence (AI)‐assisted design and bioinspired dynamic membranes for the future of chiral technologies.