Microenvironment Mechanical Torque from ZnFe <sub>2</sub> O <sub>4</sub> (ZFO) Micromotors Inhibiting Tumor Migration
Abstract
Abstract Mechanical force attracts booming attention with the potential to tune the tumor cell behavior, especially in cell migration. However, the current approach for introducing mechanical input is difficult to apply in vivo. How the mechanical force affects cell behavior in situ also remains unclear. In this work, an intelligent miniaturized platform is constructed with magnetic ZnFe 2 O 4 (ZFO) micromotors. The wireless ZFO can self‐assemble in situ and rotate to generate mechanical torque of biologically relevant piconewton‐scale at the target tumor site. It is observed unexpectedly that enhanced in situ mechanical rotating torque from ZFO micromotors and the active fluid inhibit the migration of highly invasive A549 tumor cells. The down‐regulation of the Piezo1 channel and the suppressed signaling of ROCK1 in mechano‐adaptive tumor cells is found to be related to the inhibition effect. With effectiveness confirmed with the zebrafish xenograft model, this platform provides a valuable toolkit for mechanobiology and force‐associated non‐invasive tumor therapy.
Article Details
Authors (16)
Tingting Jiang
Ye Feng
Chao Gao
Jiamiao Jiang
National Medical Products Administration Key Laboratory for Research and Evaluation of Drug Metabolism and Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University
Bin Chen
Suyi Liu
School of Materials Science and Engineering Sun Yat‐Sen University Guangzhou 510275 China
Dailing Du
School of Materials Science and Engineering, Sun Yat-sen University
Miaomiao Ding
School of Materials Science and Engineering, Sun Yat-sen University
Jinghui Rong
School of Materials Science and Engineering, Sun Yat-sen University
Zongzhen Liao
Wensheng Li
Daniela A. Wilson
Institute for Molecules and Materials
Yingfeng Tu
National Medical Products Administration Key Laboratory for Research and Evaluation of Drug Metabolism and Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University
Shuqin Song
The Key Lab of Low‐Carbon Chemistry & Energy Conservation of Guangdong Province PCFM Lab School of Materials Science and Engineering School of Chemical Engineering and Technology Sun Yat‐sen University Guangzhou 510275 P.R. China
Yi Wang
Fei Peng
School of Materials Science and Engineering, Sun Yat-sen University