Nocturnal Intraocular Pressure Monitoring With a Soft Contact Lens Sensor for Glaucoma Management
Abstract
ABSTRACT Measurement of nocturnal intraocular pressure (IOP) is essential for glaucoma management, yet recumbent IOP fluctuations during sleep remain largely unmeasured outside the clinic. Although existing eye‐worn wearable sensors enable noninvasive IOP monitoring, limitations in sensitivity, closed‐eye performance, and overnight wearability restrict accurate assessment of nocturnal IOP changes under sleep conditions. Here, we present a soft contact lens sensor designed for continuous monitoring of nocturnal IOP in a home setting. The sensor integrates a compliant conductor–based inductive–capacitive circuit directly onto a commercial soft contact lens, enabling close conformity to the eye. This design achieves the highest IOP sensitivity reported to date among wearable soft contact lens sensors, representing a substantial improvement over our earlier designs. As a result, the sensor provides stable and accurate IOP measurements under recumbent, closed‐eye sleep conditions. Animal studies in rabbits and dogs and pilot human measurements in healthy and glaucomatous eyes support preliminary ocular tolerability and feasible sensor performance, enabling posture‐dependent IOP tracking and detection of sleep‐relevant pressure elevations under the tested conditions. These results address key limitations of earlier contact lens sensors and support at‐home monitoring of nocturnal IOP dynamics.
Article Details
Authors (20)
Yumin Dai
School of Materials Engineering Purdue University West Lafayette IN USA
Tristan Michael Long
School of Optometry Indiana University Bloomington IN USA
Oluwabunmi T. Oladele
Department of Veterinary Clinical Sciences Purdue University West Lafayette IN USA
Youngoh Lee
Weldon School of Biomedical Engineering Purdue University West Lafayette IN USA
Feiyang Li
Ziheng Wang
The Clinical Hospital of Chengdu Brain Science Institute, Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China
Yeonji Oh
Weldon School of Biomedical Engineering Purdue University West Lafayette IN USA
Junsang Lee
Weldon School of Biomedical Engineering Purdue University West Lafayette IN USA
Taewoong Park
Weldon School of Biomedical Engineering Purdue University West Lafayette IN USA
Tianhao Yu
Seokkyoon Hong
Weldon School of Biomedical Engineering Purdue University West Lafayette IN USA
Kyeonghee Lim
School of Materials Engineering Purdue University West Lafayette IN USA
Jinheon Jeong
Dawn Meyer Schneider
School of Optometry Indiana University Bloomington IN USA
Hyerim Ra
Department of Veterinary Clinical Sciences Purdue University West Lafayette IN USA
Bryan W. Boudouris
Charles D. Davidson School of Chemical Engineering
Gillian C. Shaw
School of Veterinary Medicine University of Wisconsin‐Madison Madison WI USA
Shin Ae Park
Department of Veterinary Clinical Sciences Purdue University West Lafayette IN USA
Pete S. Kollbaum
School of Optometry Indiana University Bloomington IN USA
Chi Hwan Lee
School of Materials Engineering Purdue University West Lafayette IN USA