Pathology‐Driven Design of a Biomimetic Ferromagnetic Nanomedicine for Dual‐Mode Treatment of Ulcerative Colitis and Colitis‐Associated Colorectal Cancer
Abstract
Abstract The pathological features of ulcerative colitis (UC) involve systemic abnormalities, including immune dysregulation, iron deficiency, and microbiota imbalance, and these alterations contribute to an increased risk of colitis‐associated colorectal cancer (CAC). Current therapeutic strategies remain insufficient to address these pathological features and restore physiological homeostasis. Here, a dual‐duty nanomedicine (MAC@EGCG‐Fe 3 O 4 ), engineered with an inflammation‐homing M2‐type macrophage membrane “shell” is rationally designed and developed, which encapsulates silk fibroin nanocages loading with epigallocatechin gallate (EGCG) and ferromagnetic nanoparticles (Fe 3 O 4 ). Upon intraperitoneal injection and exposure to an alternating magnetic field (AMF), the nanomedicine selectively accumulated in inflamed lesions, enabling site‐specific therapeutic effects. Controlled AMF irradiation provided localized mild hyperthermia and reductive EGCG for UC treatment or hyperpyrexia and oxidative EGCG for treating CAC. Moreover, this therapeutic strategy reprogrammed colonic immune responses, restored mucosal integrity, alleviated iron deficiency, and modulated microbiota and its metabolites. The study highlights the therapeutic potential of a single pathology‐driven nanomedicine against both UC and CAC through AMF manipulation.
Article Details
Authors (18)
Shengsheng Liu
Department of Pharmacy Personalized Drug Research and Therapy Key Laboratory of Sichuan Province Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu 610054 China
Baoyi Li
Department of Pharmacy Personalized Drug Research and Therapy Key Laboratory of Sichuan Province Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu 610054 China
Qiang Yang
Synthetic Molecule Design and Development, Lilly Research Laboratories
Menghang Zu
Department of Pharmacy Personalized Drug Research and Therapy Key Laboratory of Sichuan Province Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu 610054 China
Haiting Xu
State Key Laboratory of Resource Insects College of Sericulture Textile, and Biomass Sciences, Southwest University Chongqing 400715 China
Bozhao Li
Pu Li
Jun Zhang
Liqi Li
Zhenhua Zhu
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry
Xiang Peng
Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology
Xiao Yang
Mohammad‐Ali Shahbazi
Department of Biomaterials and Biomedical Technology The Personalized Medicine Research Institute (PRECISION) University Medical Center Groningen University of Groningen Antonius Deusinglaan 1 Groningen AV 9713 Netherlands
Xiaoxiao Shi
Key Laboratory of Luminescence Analysis and Molecular Sensing Ministry of Education School of Materials and Energy College of Sericulture Textile and Biomass Sciences Southwest University Chongqing China
Rui L. Reis
3Bs Research Group, I3Bs — Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine University of Minho AvePark, Barco Guimaraes 4805‐017 Portugal
Subhas C. Kundu
3Bs Research Group, I3Bs — Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine University of Minho AvePark, Barco Guimaraes 4805‐017 Portugal
Guangjun Nie
CAS Center for Excellence in Nanoscience
Bo Xiao
College of Chemistry and Materials Science