Personalized 3D Vaccine Integrates Immunotherapy and Antiangiogenic Therapy to Prevent Oral Squamous Cell Carcinoma Recurrence
Abstract
Abstract The immune‐suppressive microenvironment and extensive tumor angiogenesis are key contributors to the high recurrence and mortality rates of oral squamous cell carcinoma (OSCC). To address these challenges, a personalized 3D‐printed anti‐tumor vaccine (3D‐Vax‐L) is developed that integrates whole tumor antigens from postoperative tissue lysates with the angiogenesis inhibitor, lenvatinib. This vaccine not only possesses inherent adjuvant properties but also mimics the functions of lymph nodes through its porous structure, facilitating the recruitment and maturation of immune cells. In vivo studies in OSCC animal models, including mice and rabbits, demonstrate that 3D‐Vax‐L effectively recruits and matures immune cells at postoperative sites, inhibits angiogenesis and tumor recurrence, and extends survival time, all while maintaining a stable morphology and an excellent biosafety. Furthermore, 3D‐Vax‐L supports facial integrity post‐surgery, addressing physical challenges by preventing collapse and reducing the risk of aesthetic‐related disorders. These findings suggest that 3D‐Vax‐L is a promising therapeutic technique for preventing post‐surgical OSCC relapse, particularly as it offers a new strategy for immune system activation and demonstrates significant potential for clinical translation.
Article Details
Authors (15)
Jinna Ren
Department of General Dentistry II Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing China
Tianjiao Chu
Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai P. R. China
Bozhao Li
Suying Wu
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center of Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China
Zhenlin Yang
Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering
Gengtian Sun
School and Hospital of Stomatology Jilin University Changchun Jilin China
Zefang Lu
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center of Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China
Feilong Qi
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center of Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China
Feifan Wu
School of Mechanical Engineering, Xi'an Jiaotong University 1 , Xi'an, Shaanxi 710049,
Yue Peng
School of Environment
Mengyao Li
Yuliang Zhao
University of Chinese Academy of Sciences
Guangjun Nie
CAS Center for Excellence in Nanoscience
Yuguang Wang
Suping Li