Pollen‐Based Artificial Enzyme With Efficient Biocatalysis and Immune‐Priming to Prevent Primary and Secondary Wound Infection

Abstract

ABSTRACT Bacterial infection poses a significant threat to clinical treatment due to the emergence of drug resistance and the high risk of recurrence. Here, we report the de novo design of a spiky pollen‐based vanadium artificial enzyme particle (VAE‐Pollen) that integrates potent reactive oxygen species (ROS)‐catalytic activity with immune priming to prevent both primary and secondary bacterial infections. Experimental and theoretical analyses confirm that bacteria are efficiently captured by the micro‐structured surface of VAE‐Pollen, and the introduction of oxygen vacancies modulates the electronic configuration of vanadium catalytic sites, significantly enhancing their versatile ROS‐catalytic performance. Meanwhile, VAE‐Pollen enhances bacterial capture and ROS‐triggered release of bacterial antigens, which mimics the sustained allergen exposure characteristic of natural pollen, thereby potently activating systemic defensive responses and providing sustained anti‐infective surveillance to prevent secondary wound infection. Notably, the VAE‐Pollen demonstrates significant efficacy in treating methicillin‐resistant Staphylococcus aureus ( MRSA ) and preventing its recurrence, offering a potent and intelligent antibacterial alternative that may circumvent the limitations of conventional antibiotics.