Radioactive Diselenide Bonded Covalent Organic Framework
Abstract
Abstract Covalent organic frameworks (COFs) are porous crystals of high potential in biomedical applications. The chemical bonds within COF structures are critical for the overall therapeutic performance. Here, the design and synthesis of radioactive COF are reported by introducing labile diselenide bonds into the structure backbone. This diselenide bonded COF, PorSe‐CuPt, constructed from Cu and Pt ion porphyrin units, is capable of bond cleavage upon irradiation, thus releasing the drug molecule, CBL0137, carried in the pores. Concerted with the promotion of X‐ray absorption by Pt 2 ⁺ and the enrichment of oxygen by Cu 2 ⁺, robust PANoptosis is achieved as well as improved immunosuppressive tumor microenvironment, thereby drastically enhancing the overall effectiveness of radiotherapy. The integration of diselenide bonds into the COF backbone demonstrates the possible application of clip‐off chemistry in the search for highly responsible and compatible biomaterials.
Article Details
Authors (10)
Liang Zhang
Shuo Wang
Qi‐Chao Yang
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of Education Hubei Key Laboratory of Stomatology School & Hospital of Stomatology Frontier Science Center for Immunology and Metabolism Taikang Center for Life and Medical Sciences Wuhan University Wuhan 430079 China
An Song
Yuan‐Yuan Wang
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of Education Hubei Key Laboratory of Stomatology School & Hospital of Stomatology Frontier Science Center for Immunology and Metabolism Taikang Center for Life and Medical Sciences Wuhan University Wuhan 430079 China
Wen‐Da Wang
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of Education Hubei Key Laboratory of Stomatology School & Hospital of Stomatology Frontier Science Center for Immunology and Metabolism Taikang Center for Life and Medical Sciences Wuhan University Wuhan 430079 China
Meng‐Jie Zhang
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of Education Hubei Key Laboratory of Stomatology School & Hospital of Stomatology Frontier Science Center for Immunology and Metabolism Taikang Center for Life and Medical Sciences Wuhan University Wuhan 430079 China
Hao Li
Zhi‐Jun Sun
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of Education Hubei Key Laboratory of Stomatology School & Hospital of Stomatology Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences Wuhan University Wuhan China
Hexiang Deng
Key Laboratory of Biomedical Polymers Ministry of Education, College of Chemistry and Molecular Sciences