Sequential DNA Coding for Programmable Information Encryption
Abstract
Abstract DNA molecules, with highly variable sequences and inherent programmability, emerge as a promising material for next‐generation information storage and data encryption. However, due to the singular encryption method or limited randomness of the secret key, current encryptions remain vulnerable to brute‐force attacks and the need for enhanced information security persists. This study introduces a programmable encryption strategy based on long‐chain DNA synthesis and sequential encoding. The proposed hairpin‐mediated primer exchange reaction (HAMER) system enables the generation of DNA keys and the recording of encoded information. Ultimately, encrypted text and image data can be decoded and retrieved through sequencing with customized access based on user permissions. This approach positions DNA as a high‐performance information material and establishes a programmable encryption framework, offering strong potential to meet the confidentiality, integrity, and availability demands of future information security systems.
Article Details
Authors (7)
Wenhao Fu
Institute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University
Yue Zhao
Jingtao Cao
Institute of Analytical Chemistry and Instrument for Life Science The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an Shaanxi 710049 P. R. China
Xueqi Zhao
Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, College of Chemistry, Jilin University
Feng Chen
Chunhai Fan
State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine
Yongxi Zhao
Institute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology