The global, regional, and national burden of soft tissue sarcomas and other extraosseous sarcomas, 1990-2021: A systematic analysis for the Global Burden of Disease study 2021.

Abstract

11548 Background: Soft tissue and other extraosseous sarcomas (STS) are a diverse group of cancers whose global burden have not been comprehensively reported. This study aims to analyze the burden of STS across the lifespan globally, regionally, and by Socio-demographic Index (SDI) using the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD 2021) estimates. Methods: The incidence, mortality, and disability-adjusted life-years (DALYs) due to STS from 1990 to 2021 were estimated using GBD 2021 methods. Funding for this research came from the Bill & Melinda Gates Foundation and American Lebanese Syrian Associated Charities. Results: In 2021, 96,200 (83,400-116,000) new cases of STS occurred globally (males: 52,300 [43,200-68,500], females: 43,900 [38,500-51,400]) and the global age-standardized incidence rate (ASIR) was 1.2 (1.0-1.4) per 100,000 person-years (males: 1.3 [1.1-1.7], females: 1.0 [0.9-1.2]). Among the pediatric population, the incidence rate was highest in the 0-4 age group, while in adults the incidence rate was highest in the 95+ age group. Deaths from STS were estimated to be 50,200 (43,200-61,300) globally (males: 27,200 [22,100-36,500], females: 23,000 [19,900-27,500]), with an age-standardized mortality rate (ASMR) of 0.6 (0.5-0.7) (males: 0.7 [0.6-0.9], females: 0.5 [0.5-0.6]). STS was responsible for 1,680,000 (1,430,000-2,120,000) DALYs in 2021 (males: 916,000 [732,000-1,31,000], females: 762,000 [654,000-947,000]). The global age-standardized DALY rate in 2021 was 20.5 (17.5-26.1) (males: 23.0 [18.3-33.0], females:18.3 [15.7-23.0]). Notably, in 2021, the low SDI quintile exhibited the highest ASMR of 0.9 (0.7-1.4) and age-standardized DALY rate of 33.4 (25.6-50.2). In contrast, the high SDI quintile had the highest ASIR of 2.0 (1.9-2.2). The ASIR remained stable globally between 1990 and 2021, whereas the ASMR and age-standardized DALY rates declined. Conclusions: Variations in the burden of STS were evident across different SDI levels. These findings offer insights into the distribution and discrepancies in STS burden on a global scale, which can aid policy efforts to alleviate the suffering caused by these cancers.