Treatment of Multiple Myeloma: ASCO Living Guideline, Version 2026.1.1

R Rahul Banerjee M Matthew C. Cheung (Sunnybrook Health Sciences Centre, Toronto, ON, Canada) B Benjamin Derman (3The University of Chicago, Section of Hematology/Oncology, Department of Medicine, Chicago, United States) H Hans Messersmith (American Society of Clinical Oncology (ASCO), Alexandria, VA) S Samer Al Hadidi (1Myeloma, Waldenstrom’s, and Amyloidosis Program, Section of Hematologic Malignancies and Cellular Therapy, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX) S Sita Bhella C Cynthia Chmielewski (Health Tree Foundation, Trenton, NJ) M Mohammad S. Ebraheem (Kuwait Cancer Control Center, Kuwait City, Kuwait) C C. Todd Kennedy (Independent Patient and Research Advocate, Coto de Caza, CA) S Shaji Kumar A Alan Langerak (City of Hope, Prescott, AZ) B Brea Lipe (10University of Rochester Medical Center, Rochester, United States) H Hira Mian (Department of Oncology, McMaster University, Hamilton, ON, Canada) E Eloisa Riva (1British Hospital, Bone Marrow Transplant Unit, Montevideo, Uruguay) R Rahul Seth (1SUNY Upstate Medical University, Syracuse, United States) L Latha Subramanian (Anchorage Oncology Centre, Anchorage, AK) S Saad Z. Usmani (Memorial Sloan Kettering Cancer Center, New York) T Tanya M. Wildes (12Division of Oncology and Hematology, University of Nebraska Medical Center, Omaha, NE) S Saurabh Zanwar Y Ying Zhuo L Lisa K. Hicks (St Michael's Hospital and University of Toronto, Toronto, ON, Canada)

Abstract

This guideline has been updated. This ASCO Living Guideline is reviewed on an eight-week cycle. Please see the online dynamic version for the latest updates. Living guidelines are developed for selected topic areas with rapidly evolving evidence that drives frequent change in recommended clinical practice. Living guidelines are updated on a regular schedule by a standing expert panel that systematically reviews the health literature on a continuous basis, as described in the ASCO Guidelines Methodology Manual . ASCO Living Guidelines follow the ASCO Conflict of Interest Policy Implementation for Clinical Practice Guidelines . Living Guidelines and updates are not intended to substitute for independent professional judgment of the treating clinician and do not account for individual variation among patients. See appendix for disclaimers and other important information ( Appendix 1 and Appendix 2 ). Updates are published regularly and can be found on the ASCO Publications website .

Article Details

Volume / Issue Vol. 44, Issue 22
Published August 01, 2026
ISSN 0732-183X
Publisher Lippincott Williams & Wilkins

Journal Info

Journal of Clinical Oncology

Lippincott Williams & Wilkins

ISSN: 0732-183X Health Sciences

Authors (21)

R

Rahul Banerjee

M

Matthew C. Cheung

Sunnybrook Health Sciences Centre, Toronto, ON, Canada

B

Benjamin Derman

3The University of Chicago, Section of Hematology/Oncology, Department of Medicine, Chicago, United States

H

Hans Messersmith

American Society of Clinical Oncology (ASCO), Alexandria, VA

S

Samer Al Hadidi

1Myeloma, Waldenstrom’s, and Amyloidosis Program, Section of Hematologic Malignancies and Cellular Therapy, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX

S

Sita Bhella

C

Cynthia Chmielewski

Health Tree Foundation, Trenton, NJ

M

Mohammad S. Ebraheem

Kuwait Cancer Control Center, Kuwait City, Kuwait

C

C. Todd Kennedy

Independent Patient and Research Advocate, Coto de Caza, CA

S

Shaji Kumar

A

Alan Langerak

City of Hope, Prescott, AZ

B

Brea Lipe

10University of Rochester Medical Center, Rochester, United States

H

Hira Mian

Department of Oncology, McMaster University, Hamilton, ON, Canada

E

Eloisa Riva

1British Hospital, Bone Marrow Transplant Unit, Montevideo, Uruguay

R

Rahul Seth

1SUNY Upstate Medical University, Syracuse, United States

L

Latha Subramanian

Anchorage Oncology Centre, Anchorage, AK

S

Saad Z. Usmani

Memorial Sloan Kettering Cancer Center, New York

T

Tanya M. Wildes

12Division of Oncology and Hematology, University of Nebraska Medical Center, Omaha, NE

S

Saurabh Zanwar

Y

Ying Zhuo

L

Lisa K. Hicks

St Michael's Hospital and University of Toronto, Toronto, ON, Canada