Win–Win Integration of Genetically Engineered Cellular Nanovesicles with High‐Absorbing Multimodal Phototheranostic Molecules for Boosted Cancer Photo‐Immunotherapy
Abstract
AbstractPhoto‐immunotherapy is one of the most promising cancer treatment strategies. As immunotherapeutic agents, immune checkpoint blockade antibodies against programmed cell death protein 1 (PD‐1) or programmed cell death ligand 1 (PD‐L1) exhibit substantial potential, but have to face non‐specific distribution and the subsequent immune‐related adverse events. Meanwhile, high‐performance phototheranostic agents concurrently possessing multiple phototheranostic modalities and high light‐harvesting capacity are really attractive and highly desired as touching phototheranostic modules. Herein, a win–win strategy that integrates phototheranostic molecule design and targeted immunotherapeutic module preparation is developed to construct high‐powered photo‐immunotherapy systems. Specifically, the phototheranostic agent (AOTTIT) displaying typical aggregation‐induced fluorescence extending to the second near‐infrared II window, as well as outstanding reactive oxygen species and heat production capacity is first obtained via ingenious design. Notably, AOTTIT exhibits a record high molar extinction coefficient among the reported organic multimodal phototheranostic molecules. Meanwhile, PD‐1 genetically engineered cancer cell membrane‐derived nanovesicles (PD‐1/CMNVs) are prepared as both nanocarriers and immunotherapeutic agents to camouflage AOTTIT nanoparticles, yielding a multifunctional photo‐immunotherapeutic agent (CMNPs/PD‐1) with tumor‐specific active and homologous targeting ability. The distinct suppression of primary and metastatic lung tumors after only once treatment to the primary tumor substantiated the synergistically strengthened photo‐immunotherapeutic efficiency of this win‐win strategy.
Article Details
Authors (11)
Xue Li
Xinwen Ou
Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Department of Chemical and Biological Engineering, State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR 999077, China
Zengming Yang
Center for AIE Research Guangdong Provincial Key Laboratory of New Energy Materials Service Safety College of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. China
Miaomiao Kang
Center for AIE Research Guangdong Provincial Key Laboratory of New Energy Materials Service Safety College of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. China
Weilin Xu
Danxia Li
Center for AIE Research Guangdong Provincial Key Laboratory of New Energy Materials Service Safety College of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. China
Ryan T. K. Kwok
Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Department of Chemical and Biological Engineering, State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR 999077, China
Jacky W. Y. Lam
Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Department of Chemical and Biological Engineering, State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR 999077, China
Zhijun Zhang
Dong Wang
Ben Zhong Tang
School of Science and Engineering, Guangdong Basic Research Center of Excellence for Aggregate Science, The Chinese University of Hong Kong (Shenzhen), Longgang, Shenzhen 518172, Guangdong, P. R. China