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Light-harvesting microelectronic devices for wireless electrosynthesis
Study on influencing factors and prediction model of strength and compression index of sandy silt on bank under freeze–thaw cycles
Reply to: Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation
Construction of molecular structure model of bituminous coal and study on adsorption characteristics of C2H4 and C2H2
Enhancing photovoltaic efficiency in Half-Tandem MAPbI3/ MASnI3 Perovskite solar cells with triple core-shell plasmonic nanoparticles
Safety and effectiveness of dual therapy for Helicobacter pylori infection and the effect on the glycated hemoglobin level in type 2 diabetes
Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation
New insights in the low-temperature-dependent formation of amorphous titania-coated magnetic polydopamine nanocomposites for the adsorption of methylene blue
Integrated analysis of single-cell and bulk-RNA sequencing for the cellular senescence in prognosis of lung adenocarcinoma
New insight into the protective effect of Citrullus colocynthis loaded with ZnONP cream on glutaraldehyde-induced dermatitis in health care workers
Abstract Glutaraldehyde (GLU) is mainly used in medicine by healthcare workers during infection control as a chemical disinfectant. It has been linked to numerous health hazards that range from asthma to irritation of the eye to contact dermatitis. Citrullus colocynthis (C.C.) is utilized as a supplement to combat a range of health-related problems. This study aimed to assess the effectiveness of locally applied Citrullus colocynthis extract and Citrullus colocynthis loaded with ZnONPs against dermatitis caused by the disinfectant glutaraldehyde (2%).The female mice were divided into five groups (G1, G2, G3, G4, and G5). Group 1 was used as a control. The other 4 groups (2,3,4,and 5) were sprayed with 2% GLU (2 mg/kg body weight), and the other groups (3,4,and 5) were subjected to local application of natural products (Citrullus colocynthis extract cream, ZnONP cream, and Citrullus colocynthis loaded on ZnONP cream), respectively. Each experimental animal was followed for 5 days per week for 30 days.Our findings revealed that GLU-induced dermatitis via the upregulation of TNF-α, IL-1b, NFkb 1, and ptgs2 mRNA expression and the downregulation of TGFB1 mRNA expression caused oxidative stress and altered the biochemical markers and histological appearance. However, these effects were improved by the ZnONPs, C.C. extract, and C.C.-ZnONPs.Local application of Citrullus colocynthis ZnONPs and ZnONPs had preventive effects against GLU-induced dermatitis through the suppression of oxidative stress and inflammatory markers and the enhancement of antioxidants.
Proposed framework for the integration of refractive error services into the eye health ecosystem in Kenya via social enterprise
A collaborative network analysis for the interpretation of transcriptomics data in Huntington’s disease
Influence of irrigation with oxygen plasma treated metal contaminated water on plant growth
Gossypol is a natural product with good antimalarial activity against Plasmodium falciparum clinical isolates
Dynamic supramolecular snub cubes
Spatial variability of cultural landscape vulnerability and influential factors in ethnic villages of Southeast Guizhou
Why kids need to take more risks: science reveals the benefits of wild, free play
Systematic review and meta-analysis of pain management after tonsillectomy
AbstractTonsillectomy is one of the most common operations. Tonsillectomy is also one of the most painful surgical procedures. However, there is still no satisfactory standard for postoperative pain management. Four databases (Cochrane Library, Ovid Technologies, PubMed, Web of Science) were searched for the period from 1908 to 2019. The systematic literature review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data were pooled using random-effects and fixed-effects models. Randomized controlled trials, reviews and meta-analyses were included. Primary outcomes were quantitative pain intensity in the first 24 h after tonsillectomy and on days 1, 3, and 7 postoperatively. The search yielded 1594 publications, of which 111 publications with 7566 patients, both children and adults, could be included. Intraoperative medication with intravenous dexamethasone significantly reduced pain (mean difference [MD] -0.42; 95% confidence interval [CI]: -0.61- -0.24). Among the local anesthetics, only the preoperative injection of levobupivacaine into the tonsillar compartment was able to provide sufficient pain reduction up to three days after tonsillectomy (MD: -1.92; 95% CI: -2.73 - -1.11). Preoperative or intraoperative administration of non-steroidal anti-inflammatory drugs (NSAIDs) significantly reduced pain (MD: -0.75; 95% CI: -0.87- -0.63). Steroids and NSAIDs are an important part of pain management after tonsillectomy.