Journal of Clinical Oncology
Articles in this Issue
Propensity Score–Matched External Controls in Rare Disease Trials: A Promising Tool Requiring Rigorous Validation
Integrative Molecular Analysis Reveals Determinants of Clinical Outcomes in <i>TP53</i> -Mutated Diffuse Large B-Cell Lymphoma
PURPOSE Mutations in TP53 , detected in over 20% of diffuse large B-cell lymphomas (DLBCLs), are associated with...
Neoadjuvant Sacituzumab Govitecan in Patients With Muscle-Invasive Bladder Cancer: Primary Results of the SURE-01 Trial
PURPOSE To evaluate neoadjuvant sacituzumab govitecan (SG), followed by radical cystectomy (RC), in patients with muscle-invasive bladder cancer (MIBC) who a...
In DeFi-ance of “More Is Better”: Questioning Long-Term Nirogacestat Use in Desmoid Tumors
Umbilical Cord Blood and Nonengrafting Allogeneic Cell Therapies
Reply to: In DeFi-ance of “More Is Better”: Questioning Long-Term Nirogacestat Use in Desmoid Tumors
Development and External Validation of a Transcriptome-Based Multivariable Prediction Model for Treatment-Free Remission in Chronic Myeloid Leukemia
PURPOSE Treatment-free remission (TFR) is a major therapeutic objective in chronic myeloid leukemia (CML). However, nearly 50% of patients relapse after tyrosine kinase inhibitor (...
Safety and Clinical Outcomes of Pooled Donor, Nonengrafting Expanded Progenitor Cells in Single-Unit Cord Blood Transplantation
PURPOSE Cord blood transplantation (CBT) is limited by delayed hematopoietic recovery leading to frequent use of double-unit grafts. This phase II study evaluated the safety of add...
Treatment Effect Reanalysis of the Randomized Individual Screening Trial of Innovative Glioblastoma Therapy in Newly Diagnosed Glioblastoma With External Control Data
PURPOSE Integrating external control data into clinical trial designs and analyses has the potential to accelerate drug development processes. We reanalyzed...
Less Isn't Simple: Insights From Postmastectomy Radiotherapy Deintensification Trials
A Shopping List
A story of nourishment, serendipity, and the unexpected bonds that connect us with patients.
Guanylyl Cyclase 2C–Targeted Chimeric Antigen Receptor T-Cell Therapy in Patients With Metastatic Colorectal Cancer
PURPOSE The clinical efficacies of third- or later-line therapies for metastatic colorectal cancer (CRC) are extremely limited. The purpose of this study was to evaluate the safety...
Notably Off Key: Questioning the Clinical Benefit of Perioperative Immunotherapy for Resectable Head and Neck Squamous Cell Carcinoma After KEYNOTE-689
Survival Analysis of the WSG TP-II Trial: Neoadjuvant Trastuzumab and Pertuzumab Plus Endocrine Therapy Versus Chemotherapy in Hormone Receptor–Positive/Human Epidermal Growth Factor Receptor 2–Positive Early Breast Cancer
PURPOSE The WSG TP-II trial (ClinicalTrials.gov identifier: NCT03272477 ) was designed to compare the impact of 1...