Journal of Clinical Oncology
Articles in this Issue
Association of dietary fiber and fructose with progression-free survival (PFS) in metastatic/advanced urothelial cancer (mUC) on immune checkpoint blockade (ICB) independent of correlates of metabolic health.
e16569 Background: Diet can modulate the gut microbiome and may affect ICB efficacy. In a cohort of pts with mUC on ICB, w...
Low-dose intestinal irradiation to enhance the efficacy and prognosis of PD-1 blockade in metastatic non-small cell lung cancer.
2627 Background: Intestinal low-dose irradiation (ILDR) has been shown to enhance the efficacy of immunotherapy in advance...
Updated analysis of overall survival (OS) with imetelstat (IME) in relapsed/refractory (R/R) myelofibrosis (MF) versus real-world (RW) data, and assessment of RW treatment (tx) patterns.
6573 Background: IME showed significantly longer median OS (mOS) in patients (pts) with Janus kinase inhibitor (JAKi) R/R...
Influence of peri-dose high-sensitivity troponin on clinically significant cardiac events and IL-2 interruption during post-TIL high-dose IL-2 therapy.
9557 Background: High-dose interleukin-2 (IL-2) is administered following tumor-infiltrating lymphocyte (TIL) therapy, yet...
Impact of lecture on knowledge of IM residents in diagnosing and managing CRS and ICANS.
e23313 Background: Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) will...
Racial and socioeconomic disparities in stage at diagnosis and survival in pancreatic cancer: Analysis of SEER 17 data (1998–2017).
e16338 Background: Pancreatic cancer is characterized by late stage diagnosis and high mortality. While racial and socioec...
Healthcare costs following osimertinib versus earlier-generation tyrosine kinase inhibitor initiation in non–small cell lung cancer: A U.S. claims-based study.
e20762 Background: EGFR-targeted tyrosine kinase inhibitors (EGFR-TKIs) are the standard first-line treatment for patients...
Use of G8 screening and CARG toxicity scores to predict emergency room (ER), hospital (IP) admissions, and mortality in newly diagnosed older patients with cancer undergoing chemotherapy with or without immunotherapy: Updated 3-year analysis.
e13768 Background: National guidelines recommend that older patients undergo geriatric screening, G8 and CARG. In our init...
A phase 1 study to evaluate safety, tolerability, and pharmacokinetics of LNP8701 (SOS1 inhibitor) in subjects with metastatic solid tumors.
e15162 Background: SOS1 (Son of Sevenless1) is a critical regulator of RAS signaling, facilitating RAS activation to drive...
Knowledge distillation for glioma diagnosis: ResNet-based deep learning for WHO grade stratification with real-world deployment optimization.
2083 Background: Gliomas are the most common primary CNS malignancies. WHO 2021 classification stratifies diffuse gliomas...
An exploratory study to assess the safety, immunogenicity, and preliminary anti-tumor activity of the EBV mRNA vaccine (WGc-043 injection) combined with PD-1 antibody in patients with relapsed or refractory ENKTL.
7077 Background: Extranodal NK/T cell lymphoma (ENKTL) is a rare and aggressive lymphoma associated with Epstein-Barr viru...
Copy number aberration profiling using shallow whole-genome sequencing-based LeukoPrint in multiple myeloma.
7554 Background: Multiple myeloma (MM) is a clonal plasma cell malignancy in which cytogenetic abnormalities are central t...
Updated results of surufatinib combined with gemcitabine and cisplatin and immune checkpoint inhibitor (ICI) for unresectable locally advanced or metastatic intrahepatic cholangiocarcinoma.
4136 Background: Advanced metastatic intrahepatic cholangiocarcinoma (ICC) was characterized by poor survival and limited...
Fatigue and psychostimulant use in patients with advanced cancer in an oncology palliative care clinic: A retrospective cohort study.
12069 Background: Cancer-related fatigue (CRF) is the most common symptom experienced by patients with cancer but is under...
Cancer cachexia and wasting phenotypes in relation to inpatient severity, infection, resource utilization, and mortality in U.S. cancer hospitalizations: National Inpatient Sample, 2018–2022.
e23199 Background: The obesity paradox in cancer is often defined using body mass index, which may poorly reflect metaboli...
Real-world validation of the 2025 IMWG high-risk criteria in multiple myeloma.
e19538 Background: High-risk multiple myeloma is associated with poor outcomes and inferior survival. Cytogenetic abnormal...
Tailoring post-neoadjuvant staging to tumor biology: A comparison of Neo-Bioscore, RCB, and pathologic stage in a Latin American cohort.
e12628 Background: Selecting the optimal staging system to guide adjuvant escalation after neoadjuvant chemotherapy (NAC)...
Clinical outcomes in curatively resected dMMR/MSI-H colon cancer: A retrospective analysis of a multicentric cohort.
3633 Background: Deficient mismatch repair (dMMR) colon cancer accounts for approximately 15% of localised cases and, desp...
Phase I trial of LB-100 plus doxorubicin as first-line of advanced soft tissue sarcomas: A Spanish Sarcoma Group (GEIS) study.
11572 Background: In sarcomas, blocking the phosphatase PP2A with LB-100 enhanced doxorubicin effectiveness, reducing tumo...
A deep learning approach to quantify tumor microenvironment features associated with postoperative ctDNA status and outcomes in a phase III FOLFOX-based adjuvant colon cancer trial (N0147; Alliance).
3525 Background: Tumor microenvironment (TME) features of colorectal cancer (CRC) may influence detection of circulating t...
Association of baseline microbiome and responders to immunotherapy for biochemically recurrent prostate cancer (BCR) without androgen deprivation therapy (ADT).
e17111 Background: Patients (pts) with BCR have a rising PSA after definitive therapy but negative CT/Tc99 scans. While th...
Survival outcomes of adding stereotactic radiosurgery to dual immune checkpoint blockade in melanoma brain metastases: A systematic review and meta-analysis.
9550 Background: Melanoma brain metastases (MBM) carry a poor prognosis and remain understudied in prospective trials. Dua...
Efficacy and safety of disitamab vedotin combined with toripalimab for cisplatin-refractory advanced penile cancer: A prospective single-center study (SAVE).
5034 Background: Patients with advanced penile cancer progressing on cisplatin-based chemotherapy have limited options. An...
Sex differences in adverse events associated with epidermal growth factor receptor inhibitor therapy for lung cancer.
e20744 Background: Epidermal growth factor receptor (EGFR) inhibitors (EGFRi) have revolutionized the treatment of lung ca...
Randomized phase 1 trial of cisplatin-based chemotherapy with or without sodium thiosulfate for men with metastatic germ cell tumor (GCT).
TPS5131 Background: Cisplatin-induced ototoxicity remains a major survivorship issue in men with metastatic GCT. Sanchez e...