Journal of Clinical Oncology
Articles in this Issue
Challenges in identifying HER2-low metastatic breast cancer: Real-world perspectives from a nationwide pathologist survey.
e13138 Background: HER2-low/ultralow metastatic breast cancer (mBC) is now clinically actionable with HER2-directed antibo...
First-in-class DIO3 inhibitor as a novel treatment strategy in ovarian cancer.
3101 Background: Ovarian cancer carries high mortality, driven in part by platinum resistance and a scarcity of actionable...
Symbiotic-GI-03: A randomized, double-blind, phase 3 study of first-line PF-08634404, a PD-1/VEGF bispecific antibody, in combination with mFOLFOX6 in patients with metastatic colorectal cancer (mCRC).
TPS3675 Background: Multi-agent chemotherapy regimens (eg, mFOLFOX6) ± anti-vascular endothelial growth factor (VEGF) or a...
Early recurrence and outcome determinants in NF1-associated malignant peripheral nerve sheath tumors: A single-center retrospective analysis.
e23563 Background: Malignant peripheral nerve sheath tumors (MPNST) are rare but highly aggressive malignancies in patient...
Falls among older adults with cancer: A nationwide analysis.
e13759 Background: Falls represent a failure of physiologic reserve rather than a normal consequence of aging. In oncology...
A prospective trial of single-dose neoadjuvant PD-1 blockade with or without a CD40 agonist in HPV-negative HNSCC.
6087 Background: Neoadjuvant PD-1 blockade is approved for resectable locally advanced HPV-negative HNSCC, but major patho...
Circulating tumor DNA to enhance detection of high-risk minimal residual disease in ovarian cancer relative to second look laparoscopy.
5567 Background: Minimal residual disease (MRD) following frontline treatment of ovarian cancer has been established as a...
Molecular alterations to inform anatomical-based prognosis for recurrence prediction in HNSCC.
e18040 Background: Head and neck squamous cell carcinoma (HNSCC) remains a biologically heterogeneous malignancy with poor...
Use of electronic patient reported outcomes (ePRO) to characterize patients with acute myeloid leukemia (AML) receiving intense and less intense treatment.
e18555 Background: Among adults ages 20 and older with Acute Myeloid Leukemia (AML), 5-year relative survival is 30% and l...
Efficacy of probiotics combined with glutamine compound for acute radiation enteritis during neoadjuvant chemoradiotherapy in locally advanced rectal cancer: A randomized controlled trial (NCT05406882).
3624 Background: Acute radiation enteritis (ARE) occurs in up to 80% of patients undergoing abdominal-pelvic radiotherapy,...
Spatial heterogeneity of structural inequities in diagnostic delay and survival in early-onset colorectal cancer in a large urban catchment area.
1586 Background: Disparities in early-onset colorectal cancer (EO-CRC) stage at diagnosis and survival persist despite exp...
Disparities in supportive care access and financial burden associated with chemotherapy-induced alopecia in women with breast cancer.
e13748 Background: Chemotherapy-induced alopecia (CIA) remains one of the most visible and psychologically distressing tox...
Immunotherapy rechallenge in extensive-stage small-cell lung cancer: A real-world retrospective study.
e20130 Background: Although extensive-stage small-cell lung cancer (ES-SCLC) is highly sensitive to first-line immunothera...
Impact of cirrhosis on the metabolic profile, tumor presentation, and management of MASLD-associated hepatocellular carcinoma: A systematic review and meta-analysis.
e16306 Background: Metabolically-dysfunction-associated steatotic liver disease (MASLD) affects nearly 38% of the adult wo...
LLM-generated serious illness conversation summaries to improve care for hospitalized patients: A pilot clinical trial.
1519 Background: Patients with cancer often receive intensive care near the end of life that does not align with their goa...
Pyrotinib versus pertuzumab plus trastuzumab and taxane as first-line therapy for HER2-positive advanced breast cancer: A retrospective cohort study using propensity score overlap weighting.
e13024 Background: Trastuzumab–pertuzumab–taxane (THP) and trastuzumab–pyrotinib–taxane (PyHT) are both accessible first-l...
Utility of a modified geriatric assessment to identify impairments in adults of all ages with lymphoma: A prospective observational cohort study.
7091 Background: Performance status assessments may overlook important health vulnerabilities in adults with cancer. While...
Efficacy and safety of antibody-drug conjugates in HR+/HER2− advanced breast cancer: A systematic review and meta-analysis of phase III randomized trials.
e13038 Background: Hormone receptor–positive (HR+)/HER2- advanced breast cancer is characterized by disease progression af...
Real-world EGFR, ALK, and PD-L1 testing performance and end-to-end intervals in Colombian patients with non–small cell lung cancer.
11091 Background: Timely and comprehensive EGFR, ALK, and PD-L1 testing underpins effective precision oncology care in NSC...
Population-based analysis of cancer disparities and social determinants of health in hereditary cancer syndrome carriers: A Healthy Nevada Project study.
10616 Background: Hereditary cancer syndromes account for approximately 5-10% of all cancers, the most common being Heredi...
Reactive versus prophylactic percutaneous endoscopic gastrostomy in patients with head and neck cancer: A multicenter real-world propensity score–matched analysis.
e18130 Background: Nutritional compromise is common among patients with head and neck cancer undergoing treatment, often n...
Trends and disparities in colorectal cancer among adults with diabetes mellitus in the United States: A retrospective analysis, 1999-2023.
e15674 Background: Colorectal cancer (CRC), the fourth leading cause of cancer-related deaths, affects approximately 1.5 m...
Hematology-oncology bootcamp: Educational impact of an interactive, guideline-based “101” curriculum.
9035 Background: Hematology-oncology is a rapidly evolving field, and incoming fellows often face early gaps in foundation...
Single-cell atlas of peripheral blood immune landscape in pMMR/MSS rectal cancer treated with neoadjuvant chemoradiotherapy and PD-1 blockade.
3562 Background: Most colorectal cancer (CRC) patients exhibit normal mismatch repair function/microsatellite stability (p...
EORTC GUCG 2238: “Deescalate,” a pragmatic trial to revisit intermittent androgen deprivation therapy in metastatic hormone-sensitive prostate cancer in the era of new androgen receptor pathway inhibitors.
TPS5150 Background: The systemic standard of care treatment in patients with metastatic hormone-sensitive prostate cancer...