Journal of Clinical Oncology
Articles in this Issue
Age and frailty analyses of transplant-ineligible (TIE) patients (pts) with newly diagnosed multiple myeloma (NDMM) in the phase 3 MAIA and CEPHEUS trials of daratumumab + lenalidomide-dexamethasone (Rd) and bortezomib-Rd (VRd).
7569 Background: MAIA and CEPHEUS trials demonstrated that daratumumab (Dara) with standard of care (SOC) VRd or Rd signif...
Comparing induction strategies in acute myeloid leukemia: 10-year real-world experience with 7+3 and HMA/venetoclax.
6524 Background: Hypomethylating agents (HMA) combined with venetoclax are the standard of care for AML in adults ineligib...
A pragmatic, hybrid observational study evaluating the effectiveness of trastuzumab deruxtecan (T-DXd) in patients with human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) 3+ solid tumors: DESTINY-PanTumor04.
TPS11202 Background: Patients with advanced or metastatic HER2 IHC 3+ solid tumors have limited treatment options beyond f...
Phase I study of zeaxanthin alone or in combination with pembrolizumab in metastatic solid tumors.
TPS2696 Background: Zeaxanthin is a carotinoid synthesized by plants that accumulates via dietary intake in the macula. Pr...
Racial differences in survival and prognostic factors among patients with mycosis fungoides and Sézary syndrome: A systematic review and meta-analysis.
e19112 Background: Mycosis Fungoides (MF) and its leukemic variant, Sezary Syndrome (SS), are the most common forms of cut...
New options for platinum-resistant ovarian cancer: Are we in the right direction?
e17566 Background: Ovarian cancer (OC) is the deadliest gynecologic cancer, often diagnosed in advanced stages. Even with...
Desmocolin-3–directed immunotherapy in recurrent/metastatic head and neck squamous cell carcinoma.
2503 Background: Recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC) are aggressive tumors. In p...
Impact of an audiovisual educational intervention on gastric cancer knowledge and health literacy in a Mexican population.
e22533 Background: Gastric Cancer (GC) remains a major global health burden, with rising incidence among individuals under...
Sulfidogenic bacteria and the risk of colorectal cancer.
e15727 Background: Dietary patterns rich in specific sulfur-containing foods that can be metabolized into hydrogen sulfide...
CLEAR-ACCESS: Barriers and facilitators to accessing symptom support among culturally and linguistically diverse cancer patients receiving treatment.
e13520 Background: Patients from culturally and linguistically diverse (CALD) backgrounds experience inequities in cancer...
Palliative care engagement, advance care planning, and healthcare utilization in hepatobiliary malignancies.
e24046 Background: Although advance care planning (ACP) is central to goal-concordant oncology care, its implementation in...
Practice disparities in palliative care utilization across different solid malignancies in the United States: Geographic trends and impact on hospital outcomes.
e24090 Background: Palliative care is a specialized approach for patients with life limiting illness. Utilization disparit...
A meta-analysis and systematic review of cardiac adverse events in patients with HER2-altered non–small cell lung cancer (NSCLC) enrolled in clinical trials.
e24026 Background: HER2 inhibitors showed meaningful clinical activity in HER2-altered NSCLC. HER2 inhibitors-related card...
Updated efficacy and safety of SHR-1501, an IL-15RαFc superagonist, with or without Bacille Calmette Guerin (BCG) for high-risk non-muscle invasive bladder cancer (NMIBC): A phase 1/2 study.
4626 Background: SHR-1501, an IL-15 agonist fusion protein composing of a humanized antibody Fc region fused with IL-15 an...
S2433: Randomized phase III study of second-line chemotherapy with or without panitumumab for KRAS wild type, locally advanced, or metastatic pancreatic adenocarcinoma.
TPS4264 Background: Pancreatic ductal adenocarcinoma (PDA) is characterized by driver mutations in KRA...
Quantum mechanics-based multi-tensor AI/ML as predictor of patients' overall survival, gene targets, and drug responses from their glioblastoma tumors' whole genomes.
3020 Background: The drug failure rate has increased to ~95%, despite the growth in targeted therapies. As clinical trials...
Response to HiDAC/mitoxantrone/venetoclax (HMV) in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML).
6527 Background: Outcomes for patients (pts) with R/R AML are dismal, especially after failure of Venetoclax (Ven)-based r...
A phase 1 study of the safety, pharmacokinetics, and pharmacodynamics of intermittent oral PRTX007, an IRF7-biased TLR7 agonist prodrug.
e14606 Background: Systemically active toll-like receptor 7 (TLR7) agonists have demonstrated immune-activating potential...
First results from the phase 1/2 LINKER-AL2 trial of linvoseltamab (LINVO) in patients (pts) with relapsed or refractory (RR) systemic light chain (AL) amyloidosis.
7502 Background: Systemic AL amyloidosis is caused by deposition of misfolded amyloid fibrils produced by clonal plasma ce...
Postoperative pancreatic fistula after resection of pancreatic neuroendocrine tumors: Incidence, predictors, and clinical impact.
4177 Background: Postoperative pancreatic fistula (POPF) remain a major source of morbidity after pancreatic surgery. Data...
Real-world analysis of targeted tumor genomic profiles in prostate cancer among Black and White men within the MedStar Health Network.
e22523 Background: Prostate cancer (PC) outcome disparities between White and Black men result from a combination of biolo...
Utilization and outcomes of minimally invasive resection in patients with neuroblastoma and Wilms tumor in a national cohort.
10043 Background: Tumor resection is a cornerstone of therapy for neuroblastoma (NB) and Wilms tumor (WT). Minimally invas...
Infectious complications in mantle cell lymphoma patients treated with CAR-T therapy: A real-world TriNetX analysis.
e19088 Background: Chimeric antigen receptor T-cell therapy has significantly improved outcomes for patients with relapsed...
TP53 mutation adoption of stromal-adhesion/neuronal-like programs as a driver of stress adaptation and acute myelogenous leukemia cell survival.
6545 Background: TP53 -mutated AML is associated with early relapse and poor survival, highlighting th...
“Divergent paths in the right colon”: A 24-year analysis of appendiceal cancer versus cecal cancer mortality in the United States (1999-2023) and age and sex disparities.
e15712 Background: Despite their anatomical proximity, appendiceal and cecal cancers represent distinct biological entitie...