Journal of Clinical Oncology
Articles in this Issue
Racial and rural-urban disparities in radiotherapy utilization for oral cavity and pharyngeal cancers: A SEER analysis from 2013-2022.
e18101 Background: Head and neck cancers accounted for 1,464,550 new cases and 487,993 deaths across the world in 2020 and...
Defining a long-term benefit phenotype to PD-1 inhibitors in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC): A multicentre retrospective study.
6050 Background: Limited data exists on predictors of durable benefit to PD-1 inhibitors in R/M HNSCC. We aimed to identif...
Reevaluating the comparative effectiveness of glucagon-like peptide-1 receptor agonists (GLP-1RA) vs aspirin for colorectal cancer prevention in type 2 diabetes.
e15690 Background: Recent studies suggest that aspirin and GLP-1RA may reduce the risk of colorectal cancer (CRC). A recen...
Comparison of baseline gut microbiome features between response subgroups of patients (pts) with advanced melanoma undergoing immune checkpoint inhibitor (ICI) therapy.
9528 Background: Gut microbiome composition has been implicated as a potential biomarker of response to ICIs in melanoma p...
Penpulimab (AK105) combined with cetuximab as first-line treatment in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC): A phase II clinical trial.
6029 Background: Combination therapy with PD-1 and EGFR inhibitors has shown promising efficacy in recurrent/metastatic he...
Paired urine and plasma ctDNA profiling to enable longitudinal molecular monitoring during HER2 ADC bladder preserving therapy in muscle-invasive bladder cancer (HOPE03).
e16608 Background: Although trimodal therapy is the standard organ-preserving approach for muscle-invasive bladder cancer...
Development of payload-resistant human ovarian cancer cell lines to better understand antibody-drug conjugate sequencing and resistance mechanisms.
5549 Background: Within gynecologic oncology, limited data exist regarding mechanisms of resistance to antibody-drug-conju...
A preventable cancer with unequal outcomes: Cervical cancer disparities in Wisconsin, 2014–2021.
e22595 Background: Cervical cancer remains a preventable cause of morbidity and mortality in the United States, with avail...
Metformin use and outcomes among breast cancer patients on immunotherapy: Insights from a real-world cohort.
e23086 Background: An obesity-related cancer, 1 in 3 adults with breast cancer have preexisting type 2 diabetes (T2D) at d...
A phase 1a/b study of RGT-61159, an oral MYB splicing modulator, in patients with advanced adenoid cystic carcinoma and colorectal cancer.
3089 Background: MYB is a master regulator of cell proliferation, self-renewal, and differentiation processes and its aber...
A phase 1 study of BGB-B2033 (GPC3 x 4-1BB bispecific antibody) monotherapy in patients with selected advanced or metastatic solid tumors: First disclosure of clinical data.
3016 Background: GPC3 is a tumor-specific antigen that is highly expressed in hepatocellular carcinoma (HCC) and squamous...
Remote physical activity intervention for young Hispanic breast cancer survivors with persistent post-surgical pain.
e12699 Background: Young breast cancer survivors frequently experience persistent post-breast surgery pain syndrome (PBSPS...
A phase I/II study of safety/efficacy using lurbinectedin, combined with ipilimumab, and nivolumab, for advanced soft tissue sarcomas (NCT05876715).
TPS11599 Background: Soft tissue sarcoma (STS) cells exhibit heightened immunogenicity during the early stages of the dise...
Comparative effectiveness of first-/second-generation EGFR-TKI combination therapy versus third-generation EGFR-TKI monotherapy in previously untreated advanced <i>EGFR</i> -mutant NSCLC: A real-world, retrospective study in China.
e20726 Background: At present, third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs)...
Impact of anemia on real-world outcomes in myelofibrosis: A propensity-matched analysis.
e18609 Background: Anemia is a frequent complication of myelofibrosis (MF) and is embedded in widely used prognostic syste...
Prevalence and clinical significance of AR-V7 in extra-prostatic malignancies: A systematic review.
e15181 Background: Androgen receptor splice variant 7 ( AR-V7 ) is a constitutivel...
Analyzing hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) expression and survival in patients with hepatocellular carcinoma (HCC) using cBioPortal.
e16236 Background: The ketogenic diet (KD) has been shown to up-regulate the rate-limiting enzyme of ketogenesis (Lan, 202...
Evaluating the impact of multi-level interventions on immunohistochemistry uptake in breast cancer patients in Nigeria: A retrospective cross-sectional study.
e13639 Background: Breast cancer (BCA) is the most common malignancy globally, with highest mortality in Sub-Saharan Afric...
Advancing equity in precision oncology: Impact of in-house NGS for NSCLC in a safety-net hospital.
e20704 Background: Next-generation sequencing (NGS) is essential for NSCLC management, yet access remains inequitable. We...
Comparative safety of immune checkpoint inhibitor–chemotherapy regimens across multiple tumor types: A systematic review and network meta-analysis.
e14571 Background: Immune checkpoint inhibitors (ICIs) combined with chemotherapy have become standard first-line treatmen...
Impact of electronic patient-reported outcome measure (ePROM)–triggered, collaborative care (CC)–based symptom intervention on depression and anxiety in young adults (YAs) with cancer.
12007 Background: YAs with cancer, defined as those diagnosed prior to the age of 40, may experience greater symptom burde...
Impact of bevacizumab on the efficacy of antibody–drug conjugates as later-line treatment of basal-like immune-suppressed triple-negative breast cancer.
1020 Background: Basal-like immune-suppressed (BLIS) triple-negative breast cancer (TNBC) is associated with a poor progno...
AQUARIUS: A longitudinal multi-center molecular biomarker discovery registry for patients with hematologic malignancies.
TPS7105 Background: Despite therapeutic innovations over the past decade in hematologic malignancies, there remains a sign...
A digital health intervention to enhance well-being among adolescent and young adult survivors of cancer: Results from the EMPOWER full factorial trial.
12006 Background: Adolescent and young adult (AYA) survivors of cancer are at significant risk of adverse psychological ou...
Genome-wide association and Mendelian randomization analyses of body mass index and breast cancer risk in women of African ancestry.
10598 Background: The relationship between adiposity and breast cancer risk is complex and incompletely understood, partic...