Journal of Clinical Oncology
Articles in this Issue
Longitudinal associations between chronic health condition burden and financial hardship among adult survivors of childhood cancer: A report from the Childhood Cancer Survivor study (CCSS).
10057 Background: Childhood cancer survivors experience a large burden of chronic health conditions (CHCs) with the progression of these conditions facili...
Efficacy and safety of trastuzumab deruxtecan for metastatic HER2+ and HER2-low breast cancer: A systematic review and meta-analysis of randomised controlled trials.
e13010 Background: Trastuzumab deruxtecan (T-DXd) is a novel antibody-drug conjugate (ADC) showing significant promise in treatment of metastatic HER2+ an...
The difference of clinical and molecular characteristics between HR-positive/HER2-positive and HR-negative/HER2-positive early breast cancer: A secondary analysis of 11 clinical trials.
533 Background: HER2+ early breast cancer (EBC) are treated as an identical cluster of patients in clinical practice. However, the various status of hormo...
Immunotherapy toxicity in the curative setting.
e14579 Background: Immune checkpoint inhibitors (ICI) improve survival in the curative setting. Understanding the impact, severity, and long-term toxicity...
Trends and disparities in alcohol use and liver cell carcinoma–related mortality in the US: A 24-year retrospective study.
e16237 Background: Alcohol use (AU) and Liver cell carcinoma (LCC) are significant contributors to adult mortality worldwide. Examining trends and dispari...
Target therapy adoption for myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML): A five-year real-world analysis.
e23283 Background: Molecular testing (MT) is a cornerstone of precision oncology in hematological malignancies, yet its integration into routine practice...
TACE with or without lenvatinib as adjuvant therapy for HCC with microvascular invasion (MVI) or portal vein thrombus (Cheng’s I/II): A single-center, prospective, non-randomized cohort study.
e16214 Background: Hepatocellular carcinoma (HCC) with microvascular invasion (MVI) or portal vein tumor thrombus (PVTT) is associated with a high risk of...
Population-based assessment of leiomyosarcoma (LMS) and cancers in the Li-Fraumeni syndrome (LFS) spectrum: Implications for genetic testing criteria.
11570 Background: Data regarding the heritability of rare tumors is limited and may prevent incorporation into genetic testing criteria. This study utiliz...
Efficacy and safety of IBI363 monotherapy or in combination with bevacizumab in patients with advanced colorectal cancer.
104 Background: The prognosis of patients (pts) with microsatellite stable/proficient mismatch repair (MSS/pMMR) colorectal cancer (CRC) who failed standa...
The cancer fusionome and overexpressed druggable oncogenic signals in <i>K-RAS</i> wild-type pancreatic cancer.
e15180 Background: Pancreatic cancer has apoor prognosis and limited therapeutic options. While K-RAS mutations are prevalent in t...
Gut microbiome changes in pediatric AML and association with event free survival.
10026 Background: Pediatric acute myeloid leukemia (AML) is characterized by months of hospitalization with a high risk for infections and a higher rate o...
The non-canonical role of homologous recombination deficiency in the development of immune-cold tumor microenvironment.
e15032 Background: Homologous recombination deficiency (HRD) is an event triggered by impairment of the homologous recombination repair (HRR) pathway whic...
Exploring the prevalence of germline mutations in young-onset biliary tract cancer (BTC).
10587 Background: The American Society of Clinical Oncology (ASCO) and NCCN recommend germline testing for patients (pts) with biliary tract cancers (BTC)...
Characteristics and concomitant congenital abnormalities among newborns with cancer: A population level analysis.
10071 Background: Congenital cancers are rare, occurring in 223 per million infants annually. Neuroblastoma, leukemia, and CNS tumors are most common. Up...
Prostate adenocarcinoma to neuroendocrine tumor: A therapy-driven response?
e17024 Background: Androgen deprivation therapy (ADT) remains a cornerstone of treatment for prostate cancer. Some androgen-dependent prostate cancers evo...
HAIC plus TAE combined with tislelizumab and surufatinib in unresectable intrahepatic cholangiocarcinoma: The REACH-01 trial.
4087 Background: REACH-01 (NCT06239532) is a single-arm, open label, prospective trial, aiming to evaluate the safety and preliminary effectiveness of hep...
Using tumor growth modeling and informed neural networks as early predictive clinical endpoints.
e13590 Background: Immunotherapy has significantly improved cancer treatment outcomes but presents unique challenges in assessing response due to complex...
Predictive value of circulating tumor DNA detection for long-term survival in patients with advanced lung cancer undergoing chemoimmunotherapy.
8559 Background: Chemoimmunotherapy (ChemoIO) has emerged as the first-line standard treatment option for advanced non-small cell lung cancer (NSCLC) with...
Association of sodium-glucose co-transporter-2 inhibitors with cardiac outcomes and mortality in cancer patients: A systematic review and meta-analysis.
12022 Background: Sodium-glucose co-transporter 2 inhibitors (SGLT2is) have proven effective in improving cardiac outcomes, including heart failure (HF) h...
Bridging the gap: Palliative care outcomes in academic versus community centers for advanced non-small cell lung cancer patients.
e23081 Background: The impact of care at academic versus community centers for palliative management of non-small cell lung cancer (NSCLC) remains underex...
Comparing the impact of nivolumab & ipilimumab combination therapy vs. dabrafenib & trametinib on outcomes in malignant melanoma patients: A global propensity-matched retrospective cohort study.
e21604 Background: Malignant melanoma is a highly aggressive skin cancer with a high mortality rate. Thenivolumab-ipilimumab combination therapy and dabra...
Single-slide histology-based deep learning model for mismatch repair deficiency prediction in colorectal cancer.
3567 Background: Mismatch repair deficiency (dMMR) is a critical predictive biomarker for determining eligibility and response to immunotherapy in colorec...
Reframing hormone-positive DCIS management: Effects of adjuvant therapies and surgical extent on any invasive recurrence.
572 Background: The treatment of DCIS is still primarily informed by trials that are now decades old. We have learned since then that only invasive subseq...
A retrospective study of pyrotinib for advanced salivary duct carcinoma (SDC) with positive HER2 expression.
e18148 Background: Salivary duct carcinoma (SDC) is a rare subtype of thyroid cancer with a poor prognosis. The efficacy and safety of human epidermal gro...
Trends in cancer incidence in Singapore over the last two decades.
10554 Background: Singapore has witnessed a significant rise in cancer incidence over recent decades. The most rapid increase in age-specific incidence of...