Journal of Clinical Oncology
Articles in this Issue
Time-weighted ctDNA dynamics for precision monitoring of relapse risk in colon cancer.
3608 Background: Effective monitoring for relapse is a critical component of post-surgical care in colorectal cancer (CRC), particularly for patients who...
The evolving landscape of academic and industry partnerships in gynecologic oncology clinical trials.
9038 Background: To determine trends in the financial relationships of study investigators in gynecologic oncology trials. Methods:...
Demographic and clinical factors associated with young-onset rectal cancer: Is the Latinx population at higher risk?
11038 Background: The incidence of colorectal cancer is rising among younger adults, with some studies indicating a disproportionate increase in the Hispa...
Prevalence of histology-agnostic biomarkers in pure squamous cell carcinomas of the genitourinary tract.
4609 Background: Pure squamous cell carcinomas (SCC) of the genitourinary (GU) tract are less responsive to chemotherapy with limited therapeutic options...
Effect of branched-chain amino acid metabolic interactions between HIBADH+ tumor cells and BCAT1+ macrophages on immunotherapy response in advanced NSCLC.
e20601 Background: Tumor immune checkpoint inhibitors (ICIs) have been established as the first-line standard treatment for advanced NSCLC with negative d...
Impact of body mass index on immunotherapy outcomes and complications in solid tumor patients: A real-world evidence analysis.
2603 Background: Obesity alters immune function by modifying cytokine profiles and altering immune cells. Body mass index (BMI) influences cancer outcomes...
Lenvatinib plus pembrolizumab and chemotherapy versus chemotherapy in advanced, metastatic gastroesophageal adenocarcinoma: The phase 3, randomized LEAP-015 study.
4001 Background: LEAP-015 (NCT04662710), is a randomized, open-label, phase 3 study of pembrolizumab plus lenvatinib and chemotherapy as first-line treatm...
Randomized control trial to validate mitigation of chemotherapy-induced peripheral neuropathy by limb-cooling apparatus in breast cancer patients receiving paclitaxel (CECILIA).
12002 Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse event affecting patient quality of life. Limb cooling may help to...
Early signals of Inflation Reduction Act impact on small-molecule versus biologic post-approval oncology trials.
11032 Background: The Inflation Reduction Act’s Drug Price Negotiation Program (DPNP) has shifted the financial incentives for post-approval clinical deve...
Assessment of PSMA PET/CT derived predictive markers for <sup>177</sup> Lu-PSMA-617 treatment outcomes: Results from the U.S. Expanded-Access program.
5079 Background: 177 Lu-PSMA-617 (Lu-PSMA) contributes to prolong progression-free survival (PFS) and overall survival (OS) in metastatic cast...
The impact of firstline immunotherapy and tyrosine kinase inhibitors combinations versus sunitinib on clinical outcomes of favorable risk advanced renal cell carcinoma: A meta-analysis of randomized studies.
e16504 Background: Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, with clear cell carcinoma being the predominant histolog...
Completed phase 1a dose escalation study of the first oral ENPP1 inhibitor RBS2418 immunotherapy in subjects with metastatic solid tumors.
2577 Background: ENPP1 clears cGAMP and ATP in the tumor microenvironment (TME). Its expression is associated with poor prognosis in cancer and developmen...
The global and regional burden of breast cancer in females from 1990-2023: A systematic analysis for the Global Burden of Disease study 2023.
e22575 Background: Breast cancer is one of the most common cancers globally with approximately one in eight females developing breast cancer in their life...
Assessment of long-term toxicities of imatinib in CML: Experience from a tertiary care cancer centre in south India.
6564 Background: Imatinib has been the standard 1 st line drug for chronic myeloid leukemia (CML) in chronic phase for decades. Li...
Comparative efficacy of adjuvant FOLFOX versus FLOT following neoadjuvant FLOT in locally advanced gastric cancer.
e16120 Background: Perioperative FLOT is the gold-standard treatment for locally advanced gastric cancer (LAGC). However, the tolerability of adjuvant che...
The prognostic impact of TP53 mutation on survival outcomes in ALK fusion–positive lung cancer.
e20651 Background: Patients with advanced anaplastic lymphoma kinase (ALK) rearranged lung adenocarcinoma have better survival outcomes when treated with...
A phase II study of perioperative intraperitoneal paclitaxel in patients with gastric adenocarcinoma and carcinomatosis or positive cytology.
TPS4210 Background: Over the last 2 decades, intraperitoneal chemotherapy has been found to have activity for select subgroups of patients with carcinomat...
The state of the oncologist workforce in America in areas prone to natural disasters.
11084 Background: Natural disasters are increasingly common in the U.S., causing significant localized disruptions to cancer care. The American Society of...
Clinicopathologic characteristics and survival outcomes in adolescent and young adults with breast cancer.
e12508 Background: Breast cancer is the most common cancer and the leading cause of cancer-related death among adolescent and young adults (AYA) diagnosed...
Cost minimization analysis of treatment with intravenous or subcutaneous trastuzumab in patients with HER 2+ breast cancer in Morocco.
e13008 Background: Trastuzumab (TZM) is available in IV (intravenous) and SC (subcutaneous) formulations in Morocco and is indicated for the treatment of...
Phase 3 study of ivosidenib vs placebo in locally advanced or metastatic IDH1-mutant conventional chondrosarcoma untreated or previously treated with 1 systemic treatment regimen (CHONQUER).
TPS11582 Background: Conventional chondrosarcoma (CS) is the most common chondrosarcoma subtype, accounting for 85% to 90%...
Psychological interventions for anxiety in older patients with lung cancer: A systematic review.
e24046 Background: Lung cancer is the leading cause of death among cancer types and primarily occurs among older adults. Anxiety in older adults tends to...
MRI radiomics to predict outcome of neoadjuvant chemotherapy in patients with muscle invasive bladder cancer undergoing radical cystectomy.
4581 Background: Cisplatin-based neoadjuvant chemotherapy (NAC) before radical cystectomy (RC) is the standard of care in patients with muscle-invasive bl...
Pancreatic cancer mortality trends (2018-2023): Exposing racial inequities in Michigan's cancer burden.
4180 Background: Pancreatic cancer remains one of the most aggressive malignancies, with Black individuals facing significantly worse outcomes and a young...
Real-world quality of life (QOL) in patients (pts) with metastatic renal cell carcinoma (mRCC) on active surveillance (AS) in the ODYSSEY prospective observational study.
4553 Background: AS is a recognized strategy in select pts with mRCC to maximize QOL and delay potential toxicity of systemic therapy (ST); however, only...