Journal of Clinical Oncology
Articles in this Issue
Identification of immunotherapy early treatment failure in non-small cell lung cancer (NSCLC) using a novel cell-free DNA (cfDNA) tissue-agnostic genome-wide methylome enrichment assay.
8550 Background: Immune checkpoint inhibitor treatment failure constitutes a significant clinical challenge in non-small cell lung cancer (NSCLC). Molecul...
Novel analysis of 3-y results from the pivotal EPCORE NHL-1 study: Outcomes in patients (pts) with relapsed/refractory large B-cell lymphoma (R/R LBCL) and complete response (CR) at 2 y with epcoritamab (epcor) monotherapy.
7043 Background: Depth and duration of CR correlate with long-term outcomes in LBCL. Epcor is a subcutaneous (SC) CD3xCD20 bispecific antibody approved fo...
Circulating cell free DNA (ccfDNA) fragmentomics for early detection of colorectal carcinoma: A systematic review and meta-analysis.
e15054 Background: The high morbidity and mortality associated with colorectal carcinoma (CRC) is linked primarily to its late detection. Current screenin...
Initial phase 1 dose escalation data for emiltatug ledadotin (Emi-Le), a novel B7-H4-directed dolasynthen antibody-drug conjugate.
3009 Background: B7-H4 is a transmembrane protein over-expressed in breast (BC), ovarian (OC), endometrial (EC), and adenoid cystic carcinoma type 1 (ACC-...
Efficacy of TTMV HPV DNA testing for surveillance in HPV + head and neck cancer.
e18056 Background: This is a retrospective study of tumor-modified HPV DNA (TTMV) as a tool for post-treatment surveillance in patients with HPV+ head and...
Healthcare resource use in the management of advanced epithelial ovarian cancer in Canada.
e17565 Background: Treatment selection for recurrent advanced epithelial ovarian cancer (EOC) depends on sensitivity to platinum-based chemotherapy (PBC),...
Molecular profiling of head and neck cancers (HNCs): Genetic heterogeneity, immune landscape, and therapeutic targets.
e18058 Background: HNCs are a diverse group of malignancies characterized by genetic, epigenetic, and proteomic alterations that drive tumor progression,...
Disparities in survival among younger breast cancer patients: A SEER database analysis (2000–2021).
e13834 Background: Breast cancer is a leading cause of cancer-related mortality, with survival influenced by stage at diagnosis. Early detection improves...
Disparities in patients diagnosed with cancer in the inpatient and outpatient settings.
e13839 Background: Patients diagnosed with cancer in the Emergency Department or while hospitalized have been shown to present at later stages, have poore...
Difference in survival outcomes between de novo vs therapy-related neuroendocrine cancer of prostate (NCP): A SEER-based analysis.
e17167 Background: Neuroendocrine cancer of prostate (NCP) is an aggressive histological subtype of prostate cancer with poor prognosis and lack of effect...
Hypofraction radiotherapy followed by immune checkpoint inhibitors for locally advanced non-small cell lung cancer: A phase I/II trial.
8058 Background: To explore the safety and primary efficacy of hypofraction radiotherapy followed by immune checkpoint inhibitors (ICI) for stage III loca...
Comparison of efficacy and safety of lenvatinib vs. apatinib in combination with hepatic arterial infusion chemotherapy and immune checkpoint inhibitors for unresectable intrahepatic cholangiocarcinoma: A multicenter retrospective study.
e16256 Background: For unresectable intrahepatic cholangiocarcinoma (uICC), combining targeted drugs with chemotherapy (systemic or hepatic arterial infus...
Outpatient administration of idecabtagene vicleucel in relapsed refractory multiple myeloma without planned prophylaxis or remote monitoring.
e19577 Background: Idecabtagene vicleucel is a chimeric antigen receptor T-cell therapy (CAR-T) targeting the B-cell maturation antigen (BCMA) that has sh...
Initial results from a phase II study of dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-EPOCH) ± rituximab (R) + tafasitamab (tafa) for adults with newly-diagnosed (ND) Philadelphia chromosome negative (Ph-) B lymphoblastic leukemia (B-ALL).
6540 Background: For adults with ND Ph- B-ALL, treatment consists of intense multiagent chemotherapy, with outcomes linked to early measurable residual di...
Glutamine synthetase expression levels as a prognostic biomarker in fibrolamellar hepatocellular carcinoma at the National Institute of Cancerology of Mexico.
e16168 Background: Fibrolamellar hepatocellular carcinoma is a rare neoplasm with a clinicopathologic behavior that differs from conventional hepatocellul...
Artificial intelligence (AI)-powered evaluation of protein drug-targetability through subcellular-level expression profiling from immunohistochemistry (IHC) images.
3084 Background: As a standardized methodology for quantifying the targetability of proteins in drug development has yet to be established, we developed a...
Modernizing clinical trial accessibility: Integrating the AI-powered LookUpTrials app into the CTN program.
e13558 Background: Clinical trials are essential for advancing cancer therapies, yet accrual rates remain under 10% due to various barriers. The Clinical...
Efficacy of peptide receptor radionuclide therapy in combination with capecitabine and temozolomide in neuroendocrine tumors: A systematic review and meta-analysis.
e16345 Background: The combination of Peptide Receptor Radionuclide Therapy (PRRT) and Capecitabine with Temozolomide (CAPTEM) is emerging as a promising...
Gastric juice piR-1245: A promising prognostic biomarker for gastric cancer.
e16095 Background: Emerging reports demonstrated that PIWI-interacting RNAs (piRNAs) played an indispensable role in tumorigenesis. However, it still rema...
Demographic and socioeconomic disparities in early-onset squamous cell carcinoma of the cervix: A National Cancer Database analysis.
e17525 Background: It has been well established that younger patients are experiencing increasing prevalence of cancers such as breast cancer. However, th...
Evaluating acceptance of scalp cooling in patients receiving chemotherapy for primary gynecologic cancers: Lessons from a randomized controlled trial.
11127 Background: Scalp cooling is effective in preventing chemotherapy-induced alopecia (CIA) in cancer patients. However, its effect and acceptance are...
Efficacy of immune checkpoint inhibitors (ICI) in patients (pts) with central nervous system (CNS) metastases (mets) from solid tumors: A systematic review and meta-analysis.
2023 Background: Brain metastases, a common complication of solid tumors, are associated with poor outcomes. The role of ICIs in this setting remains uncl...
Patterns of failure and treatment for hepatocellular carcinoma after immune checkpoint inhibitors.
e16243 Background: Immune checkpoint inhibitors (ICIs) have become a promising approach for hepatocellular carcinoma (HCC). However, there is limited data...
Second-line treatment patterns and outcomes of advanced gastrointestinal stromal tumor: A real-world study.
11526 Background: Ripretinib has emerged as a promising second-line therapy for patients with unresectable or metastatic gastrointestinal stromal tumors (...
Patient experiences of diagnosis and treatment of invasive lobular carcinoma: A qualitative study from a prospective registry.
11111 Background: Invasive lobular carcinoma (ILC) is the second most common subtype of breast cancer and comprises 10-15% of all cases. ILC is characteri...