Journal of Clinical Oncology
Articles in this Issue
Genomic risk stratification in breast cancer: A 10-year follow-up of a single-institution prospective cohort comparing Oncotype DX and MammaPrint.
e13083 Background: This study investigates the concordance between the 21-gene recurrence score assay, Oncotype DX (ODX), and the 70-gene signature MammaP...
Survival after osimertinib dose-reduction, discontinuation in 1L <i>EGFR</i> -mutated metastatic non-small cell lung cancer (mNSCLC).
8587 Background: Osimertinib (osi) has become standard of care in 1L EGFR mt (+) mNSCLC following the FLAURA trial in patients (pts) with classical sensit...
Unlocking the potential of zolbetuximab in CLDN18.2-positive gastric cancer: A comprehensive systematic review of clinical efficacy and safety.
e16069 Background: Zolbetuximab, a monoclonal antibody targeting Claudin 18.2 (CLDN18.2), has demonstrated efficacy in treating CLDN18.2-positive gastric...
Germline evaluation of mismatch repair (MMR) genes in breast cancer patients missing Lynch syndrome criteria: Clinical behavior, preventive paths and therapeutic implications.
e22507 Background: Currently,Breast Cancer (BC) is not considered a mismatch repair (MMR)-deficiency (MMRd)–spectrum tumor. The BC patients carrying const...
Efficacy and safety of nemtabrutinib in relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma: Cohort J of the phase 2 BELLWAVE-003 study.
TPS7088 Background: Treatment options for patients with relapsed or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) can...
Overall survival (OS) with NALIRIFOX (NFX) compared to FOLFIRINOX (FFX) in patients not previously treated for metastatic pancreatic ductal adenocarcinoma (mPDAC): An external control arm study.
e16383 Background: The phase 3 NAPOLI 3 trial (NCT04083235) demonstrated significantly improved OS in patients with mPDAC treated with first-line (1L) NFX...
Differences in tumor somatic mutations by race in VA patients with colon cancer.
e15607 Background: The Veterans Health Administration (VHA) diagnoses approximately 4,000 people with colon cancer each year and conducts Next Generation...
Cancer incidence among indigenous adults in Brazil: A 19-year analysis of hospital cancer registry data (2000–2018).
e13830 Background: Cancer disparities persist among Indigenous populations due to socio-demographic, cultural, and environmental factors. In Brazil, limit...
Mortality trends in metabolic syndrome and colorectal, endometrial, and breast cancers in the US (1999–2020).
e13582 Background: Metabolic syndrome (MS) increases the risk of colorectal, endometrial, and breast cancers, contributing to significant mortality. This...
Radiation omission in patients with clinically node-negative breast cancer undergoing lumpectomy (ROSALIE).
TPS628 Background: Currently, the standard of care for patients undergoing neoadjuvant chemotherapy (NAC) and breast conserving surgery (BCS) is adjuvant...
Integrated analysis of tissue genomic sequencing and high purity circulating tumor cell RNA sequencing for prostate cancer lineage states as a prognostic factor for survival and resistance to 177Lu-PSMA-617 in patients with metastatic castrate resistant prostate cancer.
5085 Background: Genomic mutations, including RB1 , PTEN , and HRR genes, associate with poor prognosis an...
Single-cell RNA sequencing atlas of intestinal injury induced by different clinical treatments in colorectal cancer patients.
12039 Background: Colorectal cancer (CRC) patients often experience intestinal injury due to various treatment regimens, including chemotherapy (CT), chem...
Improved detection of circulating tumor DNA in patients with leiomyosarcoma with fragment size restriction.
3046 Background: Prior work has shown that detection of circulating tumor DNA (ctDNA) at time of diagnosis of leiomyosarcoma (LMS) is associated with lowe...
The role of ADAR1-mediated A-to-I RNA editing and non-editing functions in radioresistance of esophageal squamous cell carcinoma.
e16099 Background: Radiotherapy (RT) is a critical treatment for esophageal squamous cell carcinoma (ESCC), but radioresistance poses a significant challe...
Immunotherapy vs. chemotherapy run-in followed by pembrolizumab plus nab-paclitaxel in metastatic triple negative breast cancer (mTNBC): Results from a phase II study.
1112 Background: Pembrolizumab (pembro) with chemotherapy has shown survival benefit in PD-L1+ (CPS10+) mTNBC, but many responses are not durable, and pat...
Radiographic ground-glass nodules: Features and immune profiles in early-stage lung adenocarcinoma and its precursors—Insights into early detection and cancer prevention.
e20022 Background: Lung adenocarcinoma (LUAD) is the leading cause of cancer-related mortality worldwide, largely due to late-stage diagnosis. Enhanced co...
Music therapy versus cognitive behavioral therapy for anxiety in cancer survivors: A telehealth-based randomized clinical trial.
12003 Background: Anxiety is prevalent, disruptive, and under-treated among cancer survivors. While the pandemic exacerbated the mental health crisis, it...
Temporal trends of mortality due to mesothelioma among older adults in the United States: A CDC WONDER analysis on gender and race disparities.
e20097 Background: Malignant mesothelioma (MM) is a deadly cancer of the serous membranes with a dismal prognosis. Between 1990 and 2017, it killed betwee...
Implementing the bispecific outpatient safe step-up (BOSS) program for elranatamab in ambulatory treatment of multiple myeloma.
e19507 Background: Elranatamab, a BCMA-directed bispecific antibody, is highly effective in relapsed refractory multiple myeloma (RRMM). Inpatient monitor...
Time-dependent prediction model using modified DeepSurv algorithm for dynamic risk assessment of post-operative bone metastases in breast cancer.
e13109 Background: Breast cancer (BC) is the most common cancer in women, with bones being the primary site of metastases (~70%). Bone metastases often le...
Pre-treatment positron emission tomography image quality and inter-fractional tumor uptake variation for bone metastasis during biology-guided radiotherapy.
e15060 Background: In biology-guided radiotherapy (BgRT) with real-time position emission tomography (PET) guidance, PET images are acquired on the BgRT m...
Analyzing trends and disparities in polycythemia vera mortality in the U.S. from 1999 to 2020.
e18587 Background: Polycythemia Vera (PV) is a rare blood disorder characterized by excessive red blood cell production, leading to an increased risk of t...
Long-term outcomes of dynamic sentinel lymph node biopsy in clinically node-negative penile cancer.
5039 Background: Dynamic sentinel lymph node biopsy (DSLNB) has emerged as a viable alternative in management of clinically node-negative (cN0) penile can...
Prospective observational study of application of multi-target fecal FIT-DNA testing in postoperative follow-up for colorectal cancer patients.
e15642 Background: Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide, with the majority of patients undergoing surgical resectio...
FACS-based whole-genome CRISPRi screen to uncover STEAP1 regulators in prostate cancer.
e17084 Background: Six-Transmembrane Epithelial Antigen of the Prostate 1 (STEAP1) is a transmembrane protein frequently overexpressed in prostate cancer...