Browse Articles

Investigation of channel material purity in fully depleted silicon-on-insulator transistors designed for qubit applications

Silicon holds significant potential as a material for future quantum processors. Transistors built in silicon-on-insulator technology and functioning as silicon qubit devices can be fabricated using industry-standard processes, allowing for easy integration with classical control hardware. However, achieving precise management of carrier transfer within the transistor channel is essential, requiring the elimination of electrically active defects that could act as recombination centers. Optimizing such a device demands a detailed characterization of the channel to assess the material purity. This study examines the presence of defects in the channel of fully depleted silicon-on-insulator transistors designed for qubit applications. Source and drain electrodes were connected together and voltage pulses were applied to the gate contact to perform capacitance deep level transient spectroscopy (DLTS) measurements. Electrical simulations conducted using Sentaurus device simulator were used to figure out the extension of the depleted region in the channel. By adjusting the gate voltages, we were able to probe the channel and localize the electrically active defects responsible for DLTS signals. Three dominant hole traps were detected at, respectively, 0.54, 0.57, and 0.65 eV above the valence band edge in the source/drain regions and were associated with bulk and Si/SiO2 interface defects. Their origin is likely related to the damage produced during the formation of p-doping by implantation. This study highlights not only the high quality of the channel material below the gate stack but also the need to keep the source and drain regions far from the gate edges to improve the qubit stability.

Ideal-observer model of human sound localization of sources with unknown spectrum

Abstract Localization of a sound source is in essence the act of decoding the directional information with which the sound was endowed by the head and ears upon measurement by the cochlea. Yet, as the source’s directional signature is conflated with the spectral characteristics of the source and the latter is often not known to the listener, this directional signature may be obscured, hampering localization. Current localization models generally avoid this problem by considering sources whose spectrum is known to the listener. In this paper, we investigate how an ideal-observer would deal with this uncertainty of the source: by means of a prior on the source spectrum built from previous experiences. To this end, an ecologically valid prior was constructed from databases of environmental sounds and speech. Incorporation of this prior allowed to explain the results of a localization experiment in which the stimulus was varied, without any parameter fitting. It was shown that if the spectrum of the source deviates too much from those of real-world environments, this results in localization errors, because the source does not fit the prior used by the listener. Moreover, it seems that the binaural spectral gradient contains the relevant spectral information and that the ipsilateral side has more weight in the decision. We could not corroborate the experimental indication that only the positive spectral gradient values are used for localization. Finally, the model including the ecologically valid prior was also better in explaining the experimental data on localization of invariably flat spectrum stimuli, allowing for the possibility that human listeners may rather use a multi-purpose than a situation-specific spectral prior.

Integrating PtCo Intermetallic with Highly Graphitized Carbon Toward Durable Oxygen Electroreduction in Proton Exchange Membrane Fuel Cells

Abstract Exploiting robust and high‐efficiency electrocatalysts for sluggish oxygen reduction reaction (ORR) is essential for proton exchange membrane fuel cells (PEMFCs) toward long‐term operation for practical applications, yet remains challenging. Herein, the ordered PtCo intermetallic is reported with a Pt‐rich shell loaded on a highly graphitized carbon carrier (O‐PtCo@GCoNC) prepared by an impregnation annealing strategy. Systematic X‐ray spectroscopic, operando electrochemical techniques and theoretical calculations reveal that thanks to the synergistic interaction of the core–shell PtCo intermetallic structure with a tailor‐made Pt electronic configuration and highly graphitized carbon, O‐PtCo@GCoNC exhibits significantly enhanced activity and stability toward ORR. Crucially, O‐PtCo@GCoNC delivers a much‐enhanced mass activity of 0.83 A mg Pt −1 at 0.9 V versus reversible hydrogen electrode (RHE) in 0.1 m HClO 4 , which only drops by 26.5% after 70 000 cycles (0.6–1.0 V vs RHE), and 10.8% after 10 000 cycles (1.0–1.5 V vs RHE), apparently overmatching Pt/C (0.19 A mg Pt −1 , 73.7%, and 63.1%). Moreover, O‐PtCo@GCoNC employed as the cathode catalyst in H 2 /air PEMFC achieves a superb peak power density (1.04 W cm −2 at 2.06 A cm −2 ), outperforming that of Pt/C (0.86 W cm −2 at 1.79 A cm −2 ). The cell voltage loss at 0.8 A cm −2 is 28 mV after 30 000 cycles, outstripping the United States Department of Energy 2025 target.

Correction to “Universal Formation of Single Atoms from Molten Salt for Facilitating Selective CO ₂ Reduction”

Longitudinal Results From the Nationwide Just ASK Initiative to Promote Routine Smoking Assessment in American College of Surgeons–Accredited Cancer Programs

PURPOSE Persistent smoking after cancer diagnosis causes adverse outcomes while smoking cessation can improve survival. Thus, integration of smoking assessment and cessation assistance into routine cancer care is critical. Aiming for incremental practice change that could be sustained and built upon through future quality improvement (QI) projects, the American College of Surgeons initiated Just ASK in 2022 to increase implementation of smoking assessment among its accredited Cancer Programs. This manuscript describes outcomes from Just ASK. METHODS Seven hundred sixty-two programs enrolled in this cohort study, followed Plan Do Study Act methodology, and used local QI teams to facilitate practice change. The primary outcome was the ask rate (ie, patients asked/patients seen). Programs completed three surveys across the 1-year study (89.8% retention), answering questions about their program plus organizational readiness, implementation barriers, implementation strategies, and clinical practices related to assessing smoking among patients newly diagnosed with cancer. Data analysis involved descriptive statistics and analysis of change over time (eg, McNemar chi-squares). RESULTS Programs (53.1% community-based) tended to report moderate organizational readiness, multiple implementation barriers, and adoption of 4.63 ± 1.49 of eight possible implementation strategies (eg, training staff/providers). Programs reported frequency of assessing smoking status, documenting it in the electronic health record, advising patients who smoke to quit, and documenting advice and treatment increased over time (all P < .001). The ask rate increased from baseline to mid to final survey ( P < .01; 87.79% v 88.65% v 91.92%, respectively). CONCLUSION Just ASK is the latest, and by far the largest, endeavor to improve assessment of cancer patients' smoking status. Participants reported significant advances within a short time span and study results underscore the potential for national accreditation organizations to transform oncology practice.

Thermal evidences for multi-domain coexistence of freestanding VO2 crystalline microbeams with insulator–insulator transitions

Vanadium dioxide (VO2) exhibits multiple insulating states and complex transitions, both among these states and to a metallic rutile (R) phase. In this study, we investigate freestanding VO2 microbeams that undergo reversible transitions from an insulating triclinic (T) phase to an insulating monoclinic (M2) phase, followed by a transition to the R phase. The latent heat changes associated with these first-order phase transitions are monitored using a recently developed chip-based differential scanning calorimetry technique, which demonstrates exceptional sensitivity and resolving power. A series of sharp endothermic and exothermic peaks are observed during the temperature ramping process. In contrast to the abrupt and complete transformation typically observed in conventional insulator-to-metal transitions, our findings reveal a scenario in which multiple domains coexist, and phase transitions occur sequentially within each domain. These results underscore the intricate relationship between domain dynamics and the multiple phase structures in VO2. Furthermore, they highlight the potential of advanced thermal analysis techniques to detect subtle thermal signals associated with phase transition processes, providing fresh insights into the underlying mechanisms.

Dynamic numerical simulation analysis of rockburst grade evaluation based on rock mass strength

High‐Performance Organic Ultralong Room Temperature Phosphorescence Based on Biomass Macrocycle

Abstract The pursuit of sustainable, high‐performance organic ultralong room temperature phosphorescence (OURTP) materials with stimulus‐responsive properties presents a significant and enticing yet formidable challenge. Herein, an efficient strategy to confining boric acid‐based compounds into biomass macrocycle γ‐cyclodextrin through multiple interactions is developed, enabling the construction of high‐performance and multicolor OURTP doped systems. The synergistic effects of strong hydrogen bonding, C─O─B covalent cross‐linking, and host–guest encapsulation significantly suppress non‐radiative transition, culminating in an extraordinary lifetime and excellent phosphorescence quantum yield of 4.65 s and 32.8%, respectively, which are far superior to reported biomass RTP materials. Additionally, merging biomass macrocycle with phosphors contributes to multiple stimulus responses, overcoming the inherent limitations of degradation and recycling of organic RTP compounds, and dynamically modulating RTP signals through multiple‐stimulus responses, achieving the integration of multifunctional dynamic data processing techniques. This work will provide a direction for new environmentally friendly and potentially commercially available stimulus‐responsive OURTP materials.

Enhanced Photocatalytic Efficiency Through Oxygen Vacancy‐Driven Molecular Epitaxial Growth of Metal–Organic Frameworks on BiVO ₄

Abstract Efficient charge separation at the semiconductor/cocatalyst interface is crucial for high‐performance photoelectrodes, as it directly influences the availability of surface charges for solar water oxidation. However, establishing strong molecular‐level connections between these interfaces to achieve superior interfacial quality presents significant challenges. This study introduces an innovative electrochemical etching method that generates a high concentration of oxygen vacancy sites on BiVO 4 surfaces (Ov‐BiVO 4 ), enabling interactions with the oxygen‐rich ligands of MIL‐101. This reduces the formation energy and promotes conformal growth on BiVO 4 . The Ov‐BiVO 4 /MIL‐101 composite exhibits an ideal semiconductor/cocatalyst interface, achieving an impressive photocurrent density of 5.91 mA cm −2 at 1.23 V RHE , along with excellent stability. This high‐performing photoanode enables an unbiased tandem device with an Ov‐BiVO 4 /MIL‐101‐Si solar cell system, achieving a solar‐to‐hydrogen efficiency of 4.33%. The molecular‐level integration mitigates surface states and enhances the internal electric field, facilitating the migration of photogenerated holes into the MIL‐101 overlayer. This process activates highly efficient Fe catalytic sites, which effectively adsorb water molecules, lowering the energy barrier for water oxidation and improving interfacial kinetics. Further studies confirm the broad applicability of oxygen vacancy‐induced molecular epitaxial growth in various MOFs, offering valuable insights into defect engineering for optimizing interfaces and enhancing photocatalytic activity.

Neoadjuvant Chemotherapy for Newly Diagnosed, Advanced Ovarian Cancer: ASCO Guideline Update

ASCO Guidelines provide recommendations with comprehensive review and analyses of the relevant literature for each recommendation, following the guideline development process as outlined in the ASCO Guidelines Methodology Manual . ASCO Guidelines follow the ASCO Conflict of Interest Policy for Clinical Practice Guidelines . Clinical Practice Guidelines and other guidance (“Guidance”) provided by ASCO is not a comprehensive or definitive guide to treatment options. It is intended for voluntary use by clinicians and should be used in conjunction with independent professional judgment. Guidance may not be applicable to all patients, interventions, diseases or stages of diseases. Guidance is based on review and analysis of relevant literature and is not intended as a statement of the standard of care. ASCO does not endorse third-party drugs, devices, services, or therapies and assumes no responsibility for any harm arising from or related to the use of this information. See complete disclaimer in Appendix 1 and 2 (online only) for more . PURPOSE To provide updated guidance regarding neoadjuvant chemotherapy (NACT) and primary cytoreductive surgery (PCS) among patients with stage III-IV epithelial ovarian, fallopian tube, or primary peritoneal cancer (epithelial ovarian cancer [EOC]). METHODS A multidisciplinary Expert Panel convened and updated the systematic review. RESULTS Sixty-one studies form the evidence base. RECOMMENDATIONS Patients with suspected stage III-IV EOC should be evaluated by a gynecologic oncologist, with cancer antigen 125, computed tomography of the abdomen and pelvis, and chest imaging included. All patients with EOC should be offered germline genetic and somatic testing at diagnosis. For patients with newly diagnosed advanced EOC who are fit for surgery and have a high likelihood of achieving complete cytoreduction, PCS is recommended. For patients fit for PCS but deemed unlikely to have complete cytoreduction, NACT is recommended. Patients with newly diagnosed advanced EOC and a high perioperative risk profile should receive NACT. Before NACT, patients should have histologic confirmation of invasive ovarian cancer. For NACT, a platinum-taxane doublet is recommended. Interval cytoreductive surgery (ICS) should be performed after ≤four cycles of NACT for patients with a response to chemotherapy or stable disease. For patients with stage III disease, good performance status, and adequate renal function treated with NACT, hyperthermic intraperitoneal chemotherapy may be offered during ICS. After ICS, chemotherapy should continue to complete a six-cycle treatment plan with the optional addition of bevacizumab. Patients with EOC should be offered US Food and Drug Administration–approved maintenance treatments. Patients with progressive disease on NACT should have diagnosis reconfirmed via tissue biopsy. Patients without previous comprehensive genetic or molecular profiling should be offered testing. Treatment options include alternative chemotherapy regimens, clinical trials, and/or initiation of end-of-life care. Additional information is available at www.asco.org/gynecologic-cancer-guidelines . This guideline has been endorsed by the Society of Gynecologic Oncology.

Low-temperature growth of epitaxial BaTiO3 thin films with significant electro-optic coefficients

Barium titanate (BaTiO3, BTO) thin films, with their exceptionally high Pockels coefficients, present a promising alternative to lithium niobate (LiNbO3, LN) for integrated photonic devices. BTO's compatibility with complementary metal–oxide–semiconductor (CMOS) technology further enhances its appeal, contingent on the development of low-temperature growth processes. This study investigates the impact of growth temperature on the electro-optic (EO) performance of BTO films, revealing a clear correlation between lower growth temperatures and reduced EO coefficients. Notably, BTO films grown at 400 °C maintain significant EO coefficients of approximately 51.6 pm/V. These findings underscore the potential of low-temperature grown BTO films for high-performance EO applications. By elucidating the relationship between growth temperature, crystallinity, and EO performance, this research provides critical guidelines for fabricating high-performing BTO films compatible with CMOS technology, facilitating the advancement of next-generation photonic devices.

Pre-trained convolutional neural networks identify Parkinson’s disease from spectrogram images of voice samples

Abstract Machine learning approaches including deep learning models have shown promising performance in the automatic detection of Parkinson’s disease. These approaches rely on different types of data with voice recordings being the most used due to the convenient and non-invasive nature of data acquisition. Our group has successfully developed a novel approach that uses convolutional neural network with transfer learning to analyze spectrogram images of the sustained vowel /a/ to identify people with Parkinson’s disease. We tested this approach by collecting a dataset of voice recordings via analog telephone lines, which support limited bandwidth. The convolutional neural network with transfer learning approach showed superior performance against conventional machine learning methods that collapse measurements across time to generate feature vectors. This study builds upon our prior results and presents two novel contributions: First, we tested the performance of our approach on a larger voice dataset recorded using smartphones with wide bandwidth. Our results show comparable performance between two datasets generated using different recording platforms despite the differences in most important features resulting from the limited bandwidth of analog telephonic lines. Second, we compared the classification performance achieved using linear-scale and mel-scale spectrogram images and showed a small but statistically significant gain using mel-scale spectrograms.

Dynamic and Reversible Tuning of Hydrogel Viscoelasticity by Transient Polymer Interactions for Controlling Cell Adhesion

AbstractCells are highly responsive to changes in their mechanical environment, influencing processes such as stem cell differentiation and tumor progression. To meet the growing demand for materials used for high throughput mechanotransduction studies, simple means of dynamically adjusting the environmental viscoelasticity of cell cultures are needed. Here, a novel method is presented to dynamically and reversibly control the viscoelasticity of naturally derived polymer hydrogels through interactions with poly (ethylene glycol) (PEG). Interactions between PEG and hydrogel polymers, possibly involving hydrogen bonding, stiffen the hydrogel matrices. By dynamically changing the PEG concentration of the solution in which polymer hydrogels are incubated, their viscoelastic properties are adjusted, which in turn affects cell adhesion and cytoskeletal organization. Importantly, this effects is reversible, providing a cost‐effective and simple strategy for dynamically adjusting the viscoelasticity of polymer hydrogels. This method holds promise for applications in mechanobiology, biomedicine, and the life sciences.

Clonal Hematopoiesis in Women With Breast Cancer

PURPOSE Clonal hematopoiesis (CH) has been associated with a variety of adverse outcomes, most notably hematologic malignancy and ischemic cardiovascular disease. A series of recent studies also suggest that CH may play a role in the outcomes of patients with solid tumors, including breast cancer. Here, we review the clinical and biological data that underlie potential connections between CH, inflammation, and breast cancer, with a focus on the prevalence and impact of clonal hematopoiesis of indeterminate potential in patients with breast cancer. METHODS We summarize data from multiple studies, including a series of cohorts of patients with breast cancer, to assess the prevalence of CH, the relationship between CH and exposure to cytotoxic therapy, and the correlation between CH and breast cancer–specific outcomes. RESULTS Our findings indicate that CH is prevalent among patients with breast cancer, particularly those treated with cytotoxic therapies. However, there are no definitive data to support an association between the presence of CH and breast cancer–specific outcomes. CONCLUSION Current data do not support routine CH testing in patients with breast cancer, nor should the presence of CH influence decisions regarding breast cancer therapy in most patients. However, larger, long-term studies are necessary to further define the implications of CH in patients with breast cancer and guide clinical decision making.

Enhancement of thermoelectric power factor in CaGe2 films through interlayer atomic modulation

Group IVA elements Si and Ge and their compounds possess abundant natural distribution and excellent electrical properties that are widely utilized in Si-based technology. The exploration for potentially high-performance thermoelectric materials within the Group IVA elements is a viable pursuit. In this work, Ca intercalated Germanene-CaGe2 films were grown on sapphire substrates by molecular beam epitaxy. It is found that the partial lack of Ca between the germanene buckled layers effectively increases the Seebeck coefficient without restraining the conductivity. A maximum power factor of 170 μW/mK2 at 523 K, which is seven times larger than the stoichiometric CaGe2 film, was achieved in the Ca0.835Ge2 film by suppression of bipolar effect and formation of a Ca-deficient phase. This study presents a promising approach to tuning the thermoelectric properties of layered semimetal materials through interlayer atomic modulation, which induces the buckled structure of the framework layer, thereby modifying the electronic structure.

Facile synthesis of ultratough conductive gels with swelling and freezing resistance for flexible sensor applications

Abstract The application of flexible hydrogel sensors in extreme environments, such as low temperatures, underwater, or significant mechanical deformations, poses considerable challenges. Here, we present a simple one-pot method to fabricate ultra-tough, swelling- and freezing-resistant conductive organohydrogels without external conductive and freeze-resistant fillers. During gelation, by-products (C6H15NHCl, KCl) provide both conductivity and antifreeze properties, thus eliminating compatibility issues and dispersion challenges associated with external fillers. The resulting gel exhibits super toughness, with tensile strength reaching 10.2 MPa and stretchability up to 800% in the dry state. Following covalent crosslinking, the gel demonstrates excellent anti-swelling properties, with a swelling ratio of only 15.4% after 24 h of water immersion, while maintaining a tensile strength of 5.8 MPa and an elongation of up to 1000%. When fabricated into flexible sensors, these gels display stable electrical responsiveness and desired Gauge Factor (0.58–2.25), effectively detecting limb movements. Furthermore, the gel’s superior resistance to freezing and swelling ensures reliable signal stability under both − 20 °C and underwater conditions. These combined properties render the conductive gel a promising candidate for flexible sensing components in robotic and bionic applications.

Alkaline Adjuvant Regulates Proteolytic Activity of Macrophages for Antigen Cross‐Presentation and Potentiates Radioimmunotherapy

Abstract Failures of radiotherapy (RT) in adaptive antitumor immunomodulation often associate with recruited tissue‐repairing macrophages. Although training these macrophages to phagocytose post‐RT cancer cells reverses their protumoral performance, engulfed tumor antigens are severely underrated. In fact, regulating the processing and presentation of tumor antigens, a key determinant of tumor immunogenicity, can fundamentally affect adaptive immune responses. Here it is reported that a simple Alum‐like adjuvant (MgAl‐based hydrotalcite, bLDH) improves radioimmunotherapy via inducing antigen cross‐presentation by macrophages, independent of phenotypes. It is identified that cytidine monophosphate guanosine oligodeoxynucleotide engenders macrophages to phagocytose irradiated cancer cells. However, as semiprofessional antigen‐presenting cells, macrophages possess powerful proteolytic function that is detrimental to antigen presentation. The administration of alkaline bLDH intriguingly relieves the activity of phagolysosomal proteases with acidic pH optima by preventing phagosomal acidification resulting from the vacuolar‐type ATPase proton pump. The adjuvant‐modulated phagolysosomes thus limit antigen degradation and enhance tumor antigen cross‐presentation over tenfold. To examine from an in vivo breast tumor model, trained macrophages successfully cross‐prime antigen‐specific CD8 + T cells and curb RT‐associated metastasis. The findings propose to pay close attention to the effect of adjuvants on precision immunotherapy and highlight the positive contribution of cross‐presenting macrophages in radioimmunotherapy.

Onvansertib in Combination With Chemotherapy and Bevacizumab in Second-Line Treatment of <i>KRAS</i> -Mutant Metastatic Colorectal Cancer: A Single-Arm, Phase II Trial

PURPOSE This phase II study evaluated the efficacy and tolerability of onvansertib, a polo-like kinase 1 (PLK1) inhibitor, in combination with fluorouracil, leucovorin, and irinotecan (FOLFIRI) + bevacizumab for the second-line treatment of KRAS -mutant metastatic colorectal cancer (mCRC). PATIENTS AND METHODS This multicenter, open-label, single-arm study enrolled patients with KRAS -mutated mCRC previously treated with oxaliplatin and fluorouracil with or without bevacizumab. Patients received onvansertib (15 mg/m 2 once daily on days 1-5 and 15-19 of a 28-day cycle) and FOLFIRI + bevacizumab (days 1 and 15). The primary end point was the objective response rate (ORR), and secondary endpoints included progression-free survival (PFS), duration of response (DOR), and tolerability. Translational and preclinical studies were conducted in KRAS -mutant CRC. RESULTS Among the 53 patients treated, the confirmed ORR was 26.4% (95% CI, 15.3 to 40.3). The median DOR was 11.7 months (95% CI, 9.4 to not reached). Grade 3/4 adverse events were reported in 62% of patients. A post hoc analysis revealed that patients with no prior bevacizumab treatment had a significantly higher ORR and longer PFS compared with patients with prior bevacizumab treatment: ORR of 76.9% versus 10.0% (odds ratio of 30.0, P &lt; .001) and median PFS of 14.9 months versus 6.6 months (hazard ratio of 0.16, P &lt; .001). Our translational findings support that prior bevacizumab exposure contributes to onvansertib resistance. Preclinically, we showed that onvansertib inhibited the hypoxia pathway and exhibited robust antitumor activity in combination with bevacizumab through the inhibition of angiogenesis. CONCLUSION Onvansertib in combination with FOLFIRI + bevacizumab showed significant activity in the second-line treatment of patients with KRAS -mutant mCRC, particularly in patients with no prior bevacizumab treatment. These findings led to the evaluation of the combination in the first-line setting (ClinicalTrails.gov identifier: NCT06106308 ).

Temperature-controlled terahertz chirality and imaging in a nested split-rings metasurface

Chiral metasurfaces exhibit vast application prospects in near-field imaging, polarization conversion, and chiral sensing. In this work, we theoretically propose a temperature-tunable terahertz (THz) chiral absorber based on a metasurface of Ag–VO2 nested split-rings. Perfect absorption of left-handed circularly polarized light (LCP) exceeding 99% and weak absorption of only about 6% of right-handed circularly polarized light (RCP) are achieved at 7.24 THz in frequency. The discrepancy in absorption responses of LCP and RCP results in a large circular dichroism (CD) of 0.94. The CD value in the THz region can be actively modulated between 0.02 and 0.94 by controlling the phase transition of VO2, which is closely related to the ambient temperature. Moreover, near-field imaging and encrypted presentation are realized by leveraging the metasurface and its mirror-image properties. Our work holds significant promise in widespread fields including THz intelligent absorption, imaging, and chiral detection.

Phytochemical profiling and various biological activities of Phlomis tuberosa L.

Abstract In this study, antioxidant, anti-diabetic, anti-cholinesterase, anti-urease, anti-tyrosinase activities, chemical composition and vitamin content of extracts and essential oils obtained from flower, aerial part and roots of Phlomis tuberosa, which grows naturally in the Kazakhstan were investigated. Chlorogenic acid and ferulic acid were detected as major constituents in the methanol extracts of P. tuberosa flower (12.47 and 25.31 µg/g), aerial part (30.95 and 47.82 µg/g) and root (9.79 and 32.56 µg/g). The main vitamins in the extracts were vitamins B3, C, and E. The main constituents of the essential oils from flowers and aerial parts were n-octacosane (14.34% and 25.66%) and hexahydro farnesyl acetone (13.89% and 18.75%). Flower methanol extract exhibited the highest antioxidant activity according to β-carotene-linoleic acid, ABTS (2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt) and CUPRAC (Cupric Reducing Antioxidant Capacity) methods with IC50 values of 48.35 ± 0.84, 51.93 ± 0.85 and 65.43 ± 0.27 µg/mL, respectively. The roots hexane extract (IC50:103.2 ± 0.99 µg/mL) showed greater α-glucosidase inhibition than acarbose (IC50:128.5 ± 0.62 µg/mL). The anti-urease effect of both essential oils were higher compared to all the extracts, and the essential oil of the flowers demonstrated significant butyrylcholinesterase (BChE) inhibitory activity. This study contributes to the traditional therapeutic uses of P. tuberosa and emphasizes its value in the development of new therapeutic agents exhibiting antioxidant and anti-diabetic activity.