Journal of Clinical Oncology
Articles in this Issue
Risk factors and outcomes for steroid-refractory immune-related hepatotoxicity in locally advanced and metastatic cancer.
e24162 Background: Immune-related hepatotoxicity (IRH) is one of the common immune-related adverse events caused by immune...
Feasibility and concordance of a large language model (ChatGPT-5) as a clinical decision support tool in gynecologic oncology tumor boards: A blinded, multi-observer study.
5519 Background: The integration of artificial intelligence (AI) into oncology practice is accelerating; however, the reli...
Evaluation of the impact of regional lymph node depletion on response to immune checkpoint blockade in recurrent and metastatic head and neck squamous cell carcinoma.
6056 Background: Lymphadenectomy remains a central component of definitive treatment for head and neck squamous cell carci...
A phase I study of HPB-092, a dual FLT3/IRAK4 inhibitor, in relapsed or refractory acute myeloid leukemia.
TPS6599 Background: Fms-like tyrosine kinase 3 (FLT3) is a clinically validated oncogenic driver in acute myeloid leukemia...
Safety and efficacy results of the phase 2 study of silevertinib (BDTX-1535) in previously treated patients with non-small cell lung cancer with non-classical and C797S EGFR mutations.
8620 Background: Despite significant benefit from FDA-approved EGFR tyrosine kinase inhibitors (TKIs), patients with class...
Nationwide oncologist survey on biomarker integration and evidence-based gastric/GEJ cancer care: Practice patterns and barriers.
e16059 Background: Biomarker (BM) testing is crucial for guiding first-line systemic therapy in advanced/metastatic gastri...
Timing of chemotherapy in breast cancer: A meta-analytic evaluation of neoadjuvant versus adjuvant approaches on survival, response, and surgical outcomes.
e12543 Background: Neoadjuvant chemotherapy (NACT) has become increasingly utilized in breast cancer management, offering...
Efficacy and safety of GVAX pancreas vaccine with CRS-207 in pretreated metastatic pancreatic adenocarcinoma: A systematic review and meta-analysis.
e15201 Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies, with low survival rates a...
Subgroup analyses by disease volume and <i>de novo</i> /recurrent mHSPC in the PSMAddition study of [ <sup>177</sup> Lu]Lu-PSMA-617.
5020 Background: In the phase 3 PSMAddition study (NCT04720157), combining [ 177 L...
Adjuvant erlotinib versus observation after complete resection of <i>EGFR</i> -mutant NSCLC: Final overall survival results of Alliance A081105.
8001 Background: The ALCHEMIST clinical trial platform, launched by the National Clinical Trials Network (NCTN) in 2014, s...
Trends in mortality from malignant neoplasms and Alzheimer's dementia in adults aged 55 and older in the United States: A retrospective analysis from 1999 to 2020.
e22603 Background: There are a large number of studies in literature that have described an inverse association between Al...
Individualized radiosensitivity-guided radiation therapy for cervical cancer.
e17526 Background: Concurrent chemoradiotherapy combined with image-guided brachytherapy is the standard for locally advan...
Spatial organization of immune surveillance by germline mutation status in the Breast Cancer Family Registry.
10566 Background: Germline pathogenic variants (gPVs) are associated with increased immune infiltration in resulting tumor...
Five-year survival disparities in two population-based cohorts of adults with early-onset colorectal cancer.
11155 Background: Early-onset colorectal cancer (EO-CRC) is now the leading cause of cancer-related death in those under t...
Secondary hematologic malignancy mortality in older survivors of gastrointestinal cancer.
e18611 Background: Improved survival following gastrointestinal (GI) cancers has increased the population at risk for seco...
Real-world outcomes of trastuzumab plus chemotherapy in HER2-positive biliary tract cancers from a high-incidence region.
e16234 Background: Biliary tract cancers (BTCs), particularly gallbladder carcinoma (GBC), are aggressive malignancies wit...
Association of KRAS variant subtypes with survival and recurrence in patients with surgically treated colorectal liver metastases.
e16245 Background: KRAS mutations are common in colorectal cancer and associated with poor outcomes after colorectal liver...
Telemedicine in oncology: Impact on clinical outcomes, access to care, and future oncology practice.
e13539 Background: The COVID-19 pandemic accelerated the adoption of telemedicine in oncology to maintain continuity of ca...
Late-stage prostate cancer in Syria: A call for decentralized and early detection systems.
e23211 Background: The Syrian conflict, ongoing since 2011, has significantly disrupted healthcare delivery, particularly...
Characteristics of cancer patients undergoing molecular residual disease testing with a tumor-informed assay.
568 Background: Detection of circulating tumor DNA (ctDNA) is strongly associated with recurrence across a variety of canc...
An NCDB analysis on the demographic, treatment, and survival of ovarian papillary mucinous cystadenocarcinoma.
e17540 Background: Ovarian papillary mucinous cystadenocarcinoma (OPMC) originates from the germinal epithelium by metapla...
Socioeconomic and racial disparities in receipt of treatment among early-stage ER+/PR+ HER2- breast cancer: Insights from invasive breast cancer OncoDX recurrence score database.
520 Background: Oncotype DX Recurrence Score (RS) predicts recurrence risk and potential benefit from chemotherapy (CT) in...
Spatial pathology–driven graph neural network modeling for predicting response to neoadjuvant immunotherapy in non–small cell lung cancer.
e20024 Background: Neoadjuvant immunotherapy has significantly improved outcomes in patients with resectable NSCLC; howeve...
Efficacy and safety of commercial CD19 CAR-T (inaticabtagene autoleucel) in relapsed/refractory extramedullary B-ALL: A large multicenter real-world study.
e23343 Background: Adult patients with relapsed/refractory (R/R) extramedullary B-ALL have a dismal prognosis with convent...
Phase I/II study of concurrent intrathecal toripalimab and pemetrexed (PM) for leptomeningeal metastases (LM) from solid tumors.
2621 Background: Intrathecal (IT) programmed death-1 (PD-1) inhibitors have demonstrated safety and feasibility in leptome...