Journal of Clinical Oncology
Articles in this Issue
Does the FIGO 2018 cervical cancer staging system need revision? Insights from a global survey.
e17513 Background: FIGO 2018 incorporated imaging and nodal status into cervical cancer staging; however, concerns remain...
Uncoupling of MT1E transcription and translation in high-CNA colorectal cancer: A proteostatic adaptation as driver of aggressiveness.
e15577 Background: Somatic copy number alterations (CNAs) drive chromosomal instability in colorectal cancer (CRC). We aim...
Survival outcomes in individuals with cancer and pre-existing autoimmune disease receiving immune checkpoint inhibitors: A multicenter, propensity-matched real-world survival analysis.
11098 Background: Autoimmune disease (AID) affects approximately 5–10% of individuals with cancer. Although immune checkpo...
Characterization of ENTPD1/CD39-mediated myeloid-T-cell crosstalk and its role in immunotherapy response in triple-negative breast cancer.
e14564 Background: Immunotherapy efficacy in triple-negative breast cancer (TNBC) is limited by mechanisms of immune suppr...
Corruption as an upstream determinant of global cancer outcomes.
e23031 Background: Corruption undermines health systems globally through resource diversion and weakened governance, yet i...
Long-term incidence of hypothyroidism and thyroiditis after CAR T-cell therapy versus standard chemotherapy in hematologic malignancies: A propensity-matched multi-institutional cohort study.
11148 Background: Thyroid dysfunction is a common endocrine immune-related adverse event with modern cancer immunotherapie...
Patient experience with later line chemotherapy in four tumor types.
e24142 Background: Understanding patient experiences with prior therapies offers crucial context for assessing the quality...
Digital twin models for counterfactual prediction in NSCLC: A validation study using clinical trial data.
e20517 Background: Digital twin models (DTMs) developed on real world data can estimate a patient’s response to treatments...
COVID-19 mRNA vaccination and risk of immune-related adverse events in ICI-treated cancer patients.
2641 Background: Immune checkpoint inhibitors (ICIs) are now standard-of-care in cancer therapy; however, concerns persist...
Use of surrogate endpoints in health technology assessment: A review of company submissions for cancer drugs in Singapore.
e23147 Background: Surrogate endpoints are increasingly used to accelerate clinical trials and regulatory approval of new...
COMFORT Survey: A comparison of the comfort level of hematologic and solid tumor oncology specialists with serious illness conversations.
12102 Background: Serious illness conversations (SICs) are essential in aligning medical care with the values and goals of...
Beyond didactics: Simulation-based education in hematology/oncology training—A scoping review.
e21010 Background: Clinical oncology exposure in residency is often varied and limited, contributing to difficulty in tran...
Neoadjuvant therapy vs. standard of care in oral cavity squamous cell carcinoma: A meta-analysis.
e18069 Background: Historically, locally advanced, resectable oral squamous cell carcinoma was treated with upfront surger...
EGFR tyrosine kinase inhibitor plus angiogenesis inhibitor combination therapy in treatment-naïve <i>EGFR</i> -mutant advanced non–small cell lung cancer: A systematic review and meta-analysis.
e20754 Background: The benefit of adding angiogenesis inhibitors to EGFR-TKIs in treatment naive EGFR mutant NSCLC remains...
Frailty among hospitalized patients with pancreatic cancer: A National Inpatient analysis.
11183 Background: Frailty is increasingly recognized as a key determinant of outcomes in older adults with cancer; however...
Genetic and epigenetic modulation of CAR T-cell responses: A systematic review exploring the influence of host genetic variations and epigenetic modifications on CAR T-cell therapy outcomes.
e15197 Background: Chimeric antigen receptor (CAR) T-cell therapy demonstrates variable efficacy in hematological malignan...
Mortality trends and demographic disparities in breast cancer deaths with co-existing diabetes mellitus among U.S. adults ≥45 years, 1999–2020.
e13135 Background: Breast cancer stands out as a considerable cause of mortality attributed to cancer, and diabetes mellit...
SMS message sentiment as a predictive indicator of quality of life and program adherence in oncology nutrition.
1627 Background: A text-message based artificial intelligence nutrition platform called “Ina” was previously developed and...
Clinicopathologic characteristics and cancer-specific survival in adolescents and young adults with endometrial cancer: A population-based SEER analysis.
e17615 Background: Endometrial cancer is the most common gynecologic malignancy in the United States, with an increasing i...
Treatment patterns and outcomes in invasive lobular versus ductal breast carcinoma: A real-world analysis.
e12665 Background: Invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) differ in tumor biology; however,...
Residual cancer burden after neoadjuvant therapy in lung cancer: A single-institution cohort.
e20050 Background: Residual cancer burden (RCB) after neoadjuvant therapy may predict recurrence and survival, but real-wo...
The gap: Recognizing the inequities in oncology research and clinical practice guidelines—An analysis of clinical guidelines in multiple myeloma.
e23213 Background: Despite significant efforts to address inequities in oncology research, and American Society of Clinica...
Sentinel lymph node positivity in microinvasive breast cancer: A systematic review and meta-analysis.
e12620 Background: Breast cancer is a leading cause of cancer-related mortality. Advances in screening and imaging have in...
Toripalimab plus chemotherapy and radiotherapy for treatment-naïve advanced esophageal squamous cell carcinoma: Long-term survival and recurrence patterns.
4064 Background: Concurrent chemoradiotherapy plus PD-1 blockade is standard for locally advanced esophageal squamous cell...
Barriers to fertility preservation counseling in young cancer patients: A retrospective chart review.
e13732 Background: The possibility of infertility is a major concern for young cancer patients facing chemotherapy. While...