Journal of Clinical Oncology
Articles in this Issue
Cerebrospinal fluid proteomics to identify biomarkers for the diagnosis and prediction of leptomeningeal metastasis from non–small cell lung cancer.
e15009 Background: Leptomeningeal metastasis (LM), a terminal complication of non-small-cell lung cancer (NSCLC), lacks va...
Induction chemotherapy response–guided selection for hypoxia-directed major radiation de-escalation in T3–T4 HPV-positive oropharyngeal cancer.
6103 Background: De-escalation trials in human papillomavirus associated oropharyngeal carcinoma (HPV+ OPC) often exclude...
Targeting the Warburg effect: Mitochondrial metabolic modulation with intermittent fasting during neoadjuvant chemoradiation in rectal cancer compared with standard neoadjuvant chemoradiation and total neoadjuvant therapy.
3612 Background: Cancer cells demonstrate metabolic inflexibility characterized by glycolytic dependence and dysfunctional...
Impact of sociodemographic factors on molecular testing patterns in localized and metastatic malignancies.
e13510 Background: Next-generation sequencing (NGS) identifies actionable mutations that guide precision therapy in both l...
Epidemiological trends in colorectal cancer incidence, prevalence, and mortality burden in the United States, 1990–2023: Retrospective analysis and advanced machine learning forecasting to 2050.
e15588 Background: Colorectal cancer remains one of the leading causes of cancer incidence and mortality in the United Sta...
Inpatient mortality and length of stay associated with splanchnic vein thrombosis in gastrointestinal cancers: A National Inpatient Sample analysis.
e16335 Background: Splanchnic vein thrombosis (SVT) is a rare but serious complication in gastrointestinal (GI) cancer pat...
Body mass index and mortality in immune checkpoint inhibitor–treated cancers: A real-world propensity-matched analysis.
11069 Background: Immune checkpoint inhibitors (ICIs) are a cornerstone of treatment for multiple solid tumors, including...
Framing and availability of information regarding alternative cancer therapies by top U.S. cancer centers.
e13713 Background: Patients with a cancer diagnosis increasingly encounter online claims promoting alternative treatment t...
UGT1A1 status and clinical outcomes in pancreatic cancer patients receiving liposomal irinotecan.
e16429 Background: Pancreatic cancer (PCa) is one of the most lethal malignancies with limited effective treatment options...
Patterns of care and long-term survival in metastasizing ameloblastoma: An NCDB study.
e18153 Background: Metastasizing ameloblastoma (MA) is diagnosed when a benign but aggressive ameloblastoma spreads to dis...
Updated results from a pilot trial of neoadjuvant durvalumb in combination with tremelimuab for cisplatin-ineligible high-risk urothelial carcinoma.
e16584 Background: We previously reported that neoadjuvant immune checkpoint therapy (ICT) with durvalumab (D) plus tremel...
Temporal trends in pregnancy-associated cancer mortality in the United States: A national analysis 2018-2023.
11029 Background: Cancer during pregnancy is rare but increasing due to rising rates of early-onset cancers and more paren...
REINFORCE: A phase III randomized trial of treatment intensification with docetaxel in metastatic hormone-sensitive prostate cancer patients without deep PSA response after initial apalutamide therapy.
TPS5147 Background: Androgen deprivation therapy (ADT) plus androgen receptor pathway inhibitors (ARPIs) is the standard o...
Consumer wearables and medical care utilization in gastrointestinal cancers: A Fitbit data analysis in NIH All of Us Research Program.
11100 Background: Patients with gastrointestinal (GI) cancers may experience delayed or forgone care due to cost, travel,...
Improving cancer education and safety in rural communities through a digital literacy platform.
e23302 Background: Cancer care is increasingly complex, requiring patients to understand diagnoses, treatment options, sid...
A prospective study of the early treatment of recombinant human thrombopoietin for chemoradiation-induced thrombocytopenia in cervical squamous cell carcinoma patients.
12125 Background: To explore the early intervention timing of recombinant human thrombopoietin (rhTPO) for cancer treatmen...
Impact of targeted axillary dissection on axillary lymph node dissection rates compared with sentinel lymph node biopsy in cN1 breast cancer patients after neoadjuvant chemotherapy: A single-centre study.
e12675 Background: In clinically node positive (cN1) breast cancer patients post neoadjuvant chemotherapy (NACT), Axillary...
Clinical impact and temporal evolution of mutational signatures in metastatic lobular breast cancer.
1141 Background: Invasive lobular carcinoma (ILC) has distinct genomic features, including frequent CD...
Optimizing survivorship transitions utilizing an EHR visual alert.
e13508 Background: There is a large and growing population of cancer survivors at risk for chronic health conditions and s...
The real-world outcomes from late-line chemotherapy for advanced colorectal cancer: A population-based analysis of attrition rates, outcomes, and health care contact in a single-payer health system.
e23443 Background: Few population-level real-world studies have evaluated the uptake, health care contact time, and effica...
Mortality patterns and disparities in primary malignant brain neoplasms among U.S. adults aged ≥75 years: A 25-year retrospective analysis.
e14064 Background: Primary malignant neoplasms of the brain disproportionately affect older adults, yet population-level m...
Long-term trends in pheochromocytoma in the United States, 1975–2022: A SEER-based study.
e22593 Background: Pheochromocytoma is a rare neuroendocrine tumor, and population-level data describing long-term tempora...
RT01: A first-in-class theranostic radionuclide drug conjugate (RDC) with zirconium-89 and lutetium-177 targeting tissue factor.
e15151 Background: Tissue factor (TF) is highly expressed in various solid tumors, including pancreatic, cervical, and lun...
Outcomes after single-fraction preoperative stereotactic radiosurgery for brain metastases: A systematic review and meta-analysis.
e14016 Background: Postoperative stereotactic radiosurgery (SRS) is utilized following resection of brain metastases (BM),...
Impact of neoadjuvant immunotherapy on safety of axillary de-escalation in triple-negative breast cancer (TNBC): A propensity score–matched analysis.
e12674 Background: While the addition of immune checkpoint inhibitors (ICIs) to neoadjuvant chemotherapy (NAC) has improve...