Journal of Clinical Oncology
Articles in this Issue
The burden of childhood cancers in the South Asian Association for Regional Cooperation (SAARC) region: A GLOBOCAN 2022 analysis.
10022 Background: Countries of the South Asian Association for Regional Cooperation (SAARC) are home to approximately 600...
Metastatic renal cell carcinoma treated with pembrolizumab–lenvatinib versus nivolumab–cabozantinib: A real-world analysis.
e16519 Background: Pembrolizumab plus lenvatinib (P-L) and nivolumab plus cabozantinib (N-C) are approved first-line optio...
Initial results of a phase 1 dose exploration and expansion study of xaluritamig plus abiraterone acetate (AA) in patients (pts) with mCRPC.
5070 Background: Xaluritamig (xalu) is a STEAP1 x CD3 T-cell engager, that has shown potent, durable monotherapy activity...
Quantifying the impact of protocol design on enrollment and dropout rates in breast cancer clinical trials.
11027 Background: Clinical trial enrollment can sometimes fail due to protocol design being overly complex, including proc...
Efficacy analysis of high-dose-rate brachytherapy combined with total neoadjuvant therapy versus total neoadjuvant therapy alone.
e15663 Background: Colorectal cancer is the third most common tumors and the second leading cause of cancer-related deaths...
Regional trends in testicular cancer burden among adolescents and young adults (15–39 years), 1990–2023: A Global Burden of Disease analysis.
5030 Background: Testicular cancer is the most common solid malignancy in adolescent and young adult (AYA) males. Contempo...
Real-world outcomes of axicabtagene ciloleucel in older versus younger adults with diffuse large B-cell lymphoma.
e19102 Background: Axicabtagene ciloleucel (axi-cel) has substantially improved outcomes for patients with relapsed or ref...
Greening a chemotherapy day ward.
1567 Background: Cancer care is climate toxic and contributes to the triple planetary crisis which threatens human health...
Post-treatment cervical cancer surveillance cytology and recurrence outcomes in a large integrated healthcare system.
e17507 Background: Post-treatment cervical cancer surveillance strategies are used to facilitate timely detection of recur...
Tumor-specific drivers of PD-1/PD-L1 inhibitor brand preference in NSCLC, melanoma, and renal cell carcinoma: A U.S. oncologist perspective.
e23229 Background: Multiple PD-1/PD-L1 inhibitors are approved across solid tumors with overlapping indications. Despite c...
Initial safety and efficacy of A2B694, a logic-gated mesothelin (MSLN)–targeted Tmod chimeric antigen receptor T-cell (CAR T) therapy in patients with advanced solid tumors with HLA-A*02 loss of heterozygosity (LOH).
8579 Background: LOH may provide a means to target tumor versus normal cells, to augment the efficacy and safety of MSLN-t...
Association of NAB2–STAT6 distal fusion with risk level of metastatic disease and thoracic primary site.
11519 Background: Solitary fibrous tumors (SFTs) are defined by the NAB2–STAT6 gene fusion, but the clinical significance...
Clinical outcomes and safety of central nervous system tumor patients in phase 1 trials: A single-institution experience.
e14047 Background: Central nervous system (CNS) tumors present unique therapeutic challenges due to limited drug penetrati...
Phase I study of [ <sup>225</sup> Ac]Ac-ETN029, a DLL3-targeted radioligand therapy, in patients with advanced DLL3-expressing solid tumors.
TPS3174 Background: Delta-like ligand 3 (DLL3) is an atypical Notch ligand that is highly expressed in small cell lung can...
Gender distribution of international cancer research funding.
e21018 Background: The Lancet Commission on women, power, and cancer recommends th...
Economic factors and screening practices in global lung cancer staging disparities: A systematic review.
e22500 Background: To assess the global distribution of lung cancer staging at diagnosis and explore the impact of...
AhR as a coupler of tryptophan metabolism to immune checkpoint regulation in breast cancer.
e12579 Background: Tryptophan (Trp) is an essential amino acid metabolized through the kynurenine, serotonin, and indole p...
Long-term outcomes of SINTART 1 and SINTART 2: Two phase II trials of multimodal treatments in patients with locally advanced sinonasal carcinomas.
6120 Background: Sinonasal carcinomas (SNCs) are rare malignancies with poor prognosis. Multimodal treatments including in...
An artificial intelligence–based framework for longitudinal risk prediction in patients with cirrhosis through trajectory modeling: A multi-center prospective study in time-series cohorts.
e16011 Background: Surveillance for hepatocellular carcinoma (HCC) in adults with cirrhosis relies on fixed-interval AFP t...
Understanding patient engagement with an oncology chatbot: Thematic and sentiment analysis of medical adherence.
e13705 Background: Oral oncology treatment is an effective option, but faces challenges of suboptimal adherence. Penny, an...
Intraductal carcinoma of the prostate as a predictor of efficacy of olaparib combined with novel hormone therapy in metastatic castration-resistant prostate cancer.
e17063 Background: Intraductal carcinoma of the prostate (IDC-P) is a clinicopathological entity of prostate cancer charac...
Efficacy and safety profiles of CDK4/6 inhibitor in patients with hormone receptor–positive and human epidermal growth factor receptor 2–negative (HR+/HER2−) advanced breast cancer (ABC) from the high-altitude versus low-altitude regions: A multi-center retrospective study.
e13033 Background: Hypoxia in the high-altitude regions may alter the pharmacokinetic properties of anti-tumor drugs, incl...
Long-term mortality trends of cervical cancer among younger and middle-aged women in the United States.
e17504 Background: Despite increasing human papillomavirus (HPV) immunization rates, the incidence of cervical cancer has...
Asciminib in newly diagnosed Philadelphia chromosom–positive chronic myeloid leukemia in chronic phase (Ph+ CML-CP): A retrospective chart review study in the US.
e23076 Background: Asciminib, the first BCR:ABL1 inhibitor specifically targeting the ABL myristoyl pocket, received US FD...
Recognition and management patterns of cachexia in patients with pancreatic adenocarcinoma in a safety net hospital.
e24079 Background: Cachexia is a metabolic syndrome marked by disrupted protein and energy balance, affecting up to 80% of...