Journal of Clinical Oncology
Articles in this Issue
Dynamics of circulating monomeric C-reactive protein (mCRP) to predict outcomes with first-line alternating oxaliplatin-based chemotherapy and nivolumab in metastatic microsatellite-stable (MSS) colorectal cancer (CRC).
3606 Background: Elevated CRP levels at CRC diagnosis are consistently associated with poor outcomes, suggesting a tumor-p...
Clinicopathological characteristics and survival outcomes of liver cancer in a tertiary oncology center.
e16187 Background: Liver cancer is an aggressive malignancy with poor overall survival, particularly when diagnosed at adv...
Geographic access to ONC201 (dordaviprone) trials for pediatric diffuse midline glioma in the United States: County travel burden and social vulnerability gradients.
e14054 Background: ONC201 (dordaviprone) is currently under study for H3 K27M–mutant midline gliomas including pediatric d...
Real-world outcomes and recurrence risk factors of liver transplantation for permanently unresectable colorectal liver metastases following the TransMet trial.
3589 Background: Following the TRANSMET trial that demonstrated an overall survival (OS) benefit of liver transplantation...
Efficacy and safety of XNW27011, a Claudin-18.2 targeted (CLDN18.2) ADC, in advanced pancreatic ductal adenocarcinoma: A phase 2 study.
3039 Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a historically poor prognosis, t...
PFS2 outcomes by prior therapy from DREAMM-8: A phase 3 study assessing belantamab mafodotin (belamaf), pomalidomide, and dexamethasone (BPd) vs pomalidomide, bortezomib, and dexamethasone (PVd) in patients (pts) with relapsed/refractory multiple myeloma (RRMM).
7566 Background: B-cell maturation antigen (BCMA)–directed therapies have transformed the treatment landscape in RRMM. Bel...
Single-cell analysis and functional profiling of galectin-3 in the tumor immune microenvironment in transformed follicular lymphoma.
7055 Background: Histological transformation of follicular lymphoma (tFL) represents an aggressive subtype characterized b...
Clinical utility of DNA and RNA next-generation sequencing (NGS) for accurate diagnosis (Dx) and sub-classification of bone and soft tissue tumors (BST).
e23521 Background: BST account for only 1-2% of adult cancers but encompass >100 distinct entities with diverse histolo...
Efficacy and safety analysis of intraoperative radiotherapy for soft tissue sarcoma: The largest-sample, single-center, real-world data review.
11579 Background: This study aimed to evaluate the efficacy and safety of surgery combined with intraoperative radiotherap...
Outcomes of inpatient (IP) systemic cancer therapy in patients (pts) with solid tumors.
e23059 Background: Administration of IP cancer therapy requires substantial resources and carries risk of toxicity. Given...
Impact of DLL3 expression and tumor subtype on response to tarlatamab.
8087 Background: Tarlatamab is a DLL3-targeted bispecific T-cell engager used to treat small cell lung cancer (SCLC). SCLC...
Atrial fibrillation as a sentinel cardiovascular event in renal cell carcinoma hospitalizations: National Inpatient outcomes and rescue failure (NIS 2016–2023).
e23226 Background: Cardiovascular instability is common during renal cell carcinoma (RCC) hospitalizations, yet atrial fib...
The impact of language barriers on financial toxicity for Spanish-speaking patients undergoing cancer treatment.
e13504 Background: Financial toxicity refers to the economic burden experienced by patients due to medical care costs. Can...
Single-cell spatial analysis of the tumor immune microenvironment in NSCLC primary tumors and brain metastases.
8585 Background: Brain metastases (BrM) are associated with poor prognosis in non-small cell lung cancer (NSCLC). Although...
Operational and clinical drivers of subcutaneous PD-1/PD-L1 inhibitor adoption: A mixed-methods analysis of U.S. oncology practice patterns.
1550 Background: Subcutaneous (SC) formulations of PD-1/PD-L1 inhibitors have recently been approved across multiple solid...
Objective response rates with Ori-C101, an armored GPC3-directed CAR-T, in heavily pretreated advanced HCC: Updated results from the phase Ib BEACON study.
2508 Background: Advanced hepatocellular carcinoma (HCC) remains a high unmet-medical-need malignancy with limited therape...
ctDNA analysis in participants with renal cell carcinoma treated with adjuvant pembrolizumab or placebo in the KEYNOTE-564 trial.
4502 Background: In the phase 3 KEYNOTE-564 trial (NCT03142334), adjuvant pembrolizumab (pembro) was superior to placebo (...
Safety and efficacy of full-dose apixaban vs rivaroxaban for cancer-associated venous thromboembolism in patients with solid tumors: A real-world study.
e23439 Background: Cancer-associated venous thromboembolism (CA-VTE) is a major cause of morbidity and mortality in patien...
Enhanced recovery after surgery in major oncologic head and neck surgery: A systematic review and meta-regression.
e13616 Background: Major oncologic head and neck surgery (OHN) is associated with complex hospitalization and perioperativ...
Real-world clinical utility of liquid biopsy in NSCLC in a community oncology practice: Concordance, discordance, and impact on precision therapy.
e15068 Background: Precision oncology in NSCLC relies on tissue NGS to identify actionable mutations, but in community onc...
Feasibility of a novel oncologist-led diagnostic algorithm for Lynch syndrome in colorectal cancer patients: The ItaLynch study.
10618 Background: International guidelines recommend universal Lynch syndrome (LS) screening in colorectal cancer (CRC) us...
Helicobacter pylori infection, systemic inflammation, and colorectal cancer: A prospectively enrolled case–control study.
e15668 Background: The association between Helicobacter pylori (H. pylori) infection and colorectal cancer (CRC) remains c...
TAGNOT: A phase 1b/2 tumor-agnostic study of the selective anti-FGFR1 monoclonal antibody OM-RCA-01 in FGFR1-expressing advanced solid tumors.
TPS3166 Background: Fibroblast growth factor receptor 1 (FGFR1) plays a key role in the pathogenesis of multiple malignanc...
Prospective real time clinical validation of a novel circulating tumor–derived blood mRNA Geneverify test for diagnosis of breast cancer.
e15053 Background: Early detection is critical for the effective management of breast cancer. We performed a real-time cli...
Mitochondrial apoptosis markers in the progression of endometrioid adenocarcinoma.
e17625 Background: Endometrial cancer (EC) is one of the most common malignancies of the female reproductive system. The i...