Journal of Clinical Oncology
Articles in this Issue
Exercise therapy in survivors of gastroesophageal cancer: A phase I, randomized dose-finding study of an individually tailored, remotely supervised exercise intervention.
TPS12169 Background: Advances in perioperative systemic therapy and surgery have extended survival for patients with locor...
A phase 1 study of BGB-A3055 (anti-CCR8) with or without tislelizumab (anti–PD-1) in patients with solid tumors.
2523 Background: BGB-A3055 is a humanized monoclonal antibody targeting C-C motif...
Impact of concomitant antibiotic exposure on overall survival in patients with esophagogastric cancer treated with immune checkpoint inhibitors: A real-world cohort study.
11160 Background: Gut microbiota composition plays a critical role in mediating response to immune checkpoint inhibitors (...
Clinical significance of neutrophil-to-lymphocyte ratio dynamics during cabozantinib therapy in unresectable hepatocellular carcinoma.
e16240 Background: Neutrophil-to-lymphocyte ratio (NLR) dynamics have been reported as prognostic biomarkers in hepatocell...
Penpulimab plus oral anlotinib and capecitabine as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (R/M NPC): A multicenter, single-arm, phase 2 clinical trial.
6036 Background: Patients (pts) with NPC progressing after intensive radical treatment often have limited treatment tolera...
Molecular and demographic landscape of advanced cutaneous melanoma: A 10-year experience of a national reference laboratory in Colombia (2014–2023).
e21523 Background: Cutaneous melanoma (CM) exhibits significant biological heterogeneity. While BRAF...
Ultrasensitive tumor-informed ctDNA MRD detection to identify metastatic relapse and as predictor of recurrence-free survival following resection of early-stage NSCLC.
3060 Background: After curative-intent resection of non-small cell lung cancer (NSCLC), patients remain at risk for metast...
Real-world evaluation of germline pathogenic variants (PVs) in cancer-predisposition genes among unselected South Asian women with breast or ovarian cancer.
10513 Background: Prior reports of high frequency of BRCA1 and...
Triplet combination of anlotinib plus nab-paclitaxel and gemcitabine (AG) as a first-line strategy for advanced primary cardiac angiosarcoma: A high-volume center experience.
11562 Background: Primary cardiac angiosarcoma (PCAS) is an exceedingly rare and lethal mesenchymal malignancy characteriz...
Failure-to-rescue after acute complications in gastrointestinal cancer hospitalizations in the United States, 2018–2022.
e23118 Background: Inpatient mortality among gastrointestinal (GI) cancer hospitalizations may be influenced not only by t...
Role of intraoperative frozen section in detection and surgical decision-making of suspected gallbladder cancer during laparoscopic cholecystectomy.
e16026 Background: Gallbladder cancer (GBC) is an aggressive malignancy with a high incidence in India and is frequently d...
Global patterns and temporal trends of colorectal cancer burden in older adults aged ≥ 70 years.
e15685 Background: Colorectal cancer (CRC) is a major public health concern and represents the second leading cause of can...
Characterization and validation of a methylation signature as a prognostic marker in osteosarcoma.
10016 Background: Despite extensive research efforts, outcomes for patients with osteosarcoma have not substantially impro...
Randomized, double-blind, phase 3 TRUST-IV study of adjuvant taletrectinib vs placebo in patients with stage IB–IIIA ROS1+ non-small cell lung cancer (NSCLC).
TPS8130 Background: Taletrectinib is a next-generation, CNS-active, selective ROS1 tyrosine kinase inhibitor (TKI) approve...
Adjuvant capecitabine and trastuzumab for stage IA HER2-positive breast cancer (IRIS-A): A phase II clinical trial.
508 Background: Weekly paclitaxel and trastuzumab represents a standard option for most stage I human epidermal growth fac...
Oncoseek 2.0: An updated blood-based assay for multi-cancer early detection.
10551 Background: Early identification of cancer remains essential for improving survival and reducing downstream treatmen...
Trends in incidence, survival, and cause of death in Kaposi sarcoma in the antiretroviral therapy era.
1563 Background: Kaposi sarcoma (KS) is a malignancy driven by human herpesvirus-8 infection and is most commonly associat...
Whole-genome sequencing–based ultra-sensitive ctDNA molecular residual disease assessment in resectable gastric cancer: Results from MONSTAR-SCREEN-3.
4081 Background: Circulating tumor DNA (ctDNA) has emerged as a promising biomarker for post-surgical molecular residual d...
Oncofertility counseling practices in AYA patients diagnosed with stage I-III breast cancer.
e12685 Background: Approximately 12,000 women under 40 years are diagnosed with breast cancer annually in the US, represen...
Transforming patient care in oncology: Nationwide results of comprehensive genomic profiling–guided therapy in everyday clinical practice.
e23420 Background: In recent years, precision medicine has become one of the most thought-provoking concepts in healthcare...
Longitudinal inherited cancer care and its impact in a rural setting.
e22665 Background: Hereditary breast and ovarian cancer (HBOC) and Lynch syndromes (LS) are associated with elevated cance...
Accelerated diagnostic pathway for undifferentiated malignancy via interventional radiology triage: A comparative effectiveness study.
1568 Background: Efficiently triaging patients presenting with imaging findings suggestive of malignancy but lacking a def...
An AI-integrated patient-derived organoid platform to enable high-throughput drug response prediction in glioma.
e14086 Background: Glioma exhibits pronounced heterogeneity in both the tumor microenvironment and molecular subtypes, lea...
Safety and efficacy of sacubitril/valsartan for prevention of anthracycline-related cardiotoxicity: A meta-analysis of randomized controlled trials.
e24010 Background: Anthracycline chemotherapy is a cornerstone of therapy for breast cancer and multiple other malignancie...
Calibration of commercial AI chatbots for cancer symptom recognition: A pilot methodology study.
e13698 Background: AI chatbots are increasingly used for health queries, yet their calibration for cancer recognition rema...