Journal of Clinical Oncology
Articles in this Issue
Clinical outcomes of patients with RTK-RAS pathway alterations by treatment type: The MD Anderson Cancer Center IMPACT 2 study.
3151 Background: The receptor tyrosine kinase (RTK)-RAS signaling axis comprises distinct membrane receptors and downstrea...
Insurance, hospital, and racial disparities in surgical treatment and mortality among patients with neuroendocrine tumors: A national analysis.
4184 Background: Neuroendocrine tumors (NETs) are the second most common gastrointestinal malignancy with increasing incid...
Use of optical genome mapping (OGM) to identify atypical or cryptic <i>KMT2A</i> (11q23) rearrangements and genomic structural mechanisms in acute myeloid leukemia.
e18537 Background: KMT2A translocation and rearrangements are recurring chromosome abnormalities in ac...
On the borderline: GEJ coding as a driver for stage migration and survival difference—A SEER analysis.
e16151 Background: The classification of gastro-esophageal junction (GEJ) tumors as esophageal (ICD-O-3 C15.5, C15.2) vers...
Efficacy and safety of CD3×CD20 bispecific antibodies in Richter transformation: A systematic review of prospective trials and comparative analysis.
e19095 Background: Richter transformation (RT), the progression of chronic lymphocytic leukemia to aggressive diffuse larg...
End-of-life care quality indicators in advanced cancer patients at a Brazilian tertiary hospital.
e24083 Background: Quality of end-of-life care in advanced cancer emphasizes timely palliative integration, symptom contro...
Quantifying financial toxicity from cancer care travel in a geographically isolated U.S. health system.
e13543 Background: Geographic isolation and limited availability of subspecialty oncology services can force patients to t...
Antidepressant use and overall survival in ICI treated pan-cancer patients: A real-world analysis.
e23395 Background: Antidepressants are frequently prescribed to cancer patients, yet their impact on outcomes during immun...
Burden of breast cancer attributable to secondhand smoke in North American women: A GBD 2023 analysis (1990-2023).
e22568 Background: Breast cancer remains a leading cause of cancer-related morbidity and mortality among women. Secondhand...
First-line tislelizumab plus chemoradiotherapy for patients with advanced biliary tract cancer: A prospective, biomolecular exploratory, phase II trial.
4125 Background: Advanced biliary tract cancer (BTC) characterized by a poor prognosis, and the combination of immunothera...
Effect of IL7 on ImmTAC-mediated killing by T cells in vitro and T-cell fitness in patients.
2662 Background: A blood T cell fitness (TCF) signature, reflecting properties of naïve and stem cell memory T cells, was...
A personalized neoantigen vaccine to reprogram the immune landscape of glioblastoma.
2006 Background: Glioblastoma (GBM) remains uniformly lethal despite standard therapy. An immunosuppressive tumor microenv...
PMH-001: A first-in-human phase I study of the novel microtubule disruptor CCI-001 in patients with advanced cancer.
e15167 Background: CCI-001 is a thiocolchicine derivative, ßIII tubulin-selective microtubule disruptor being studied in t...
Validation of DiaSurv, an AI-based algorithm for stage II colon cancer risk stratification.
3524 Background: Adjuvant chemotherapy decisions in stage II colon cancer (IIA T3N0; IIB T4aN0; IIC T4bN0) remain challeng...
Trends in Patient-Reported Outcomes Measurement Information System (PROMIS) utilization in oncology research: A scoping review of ClinicalTrials.gov and PubMed (2015-2025).
e23256 Background: PROMIS (Patient-Reported Outcomes Measurement Information System) has seen rapid adoption in clinical r...
Participation of older adults (aged ≥65 years) in SWOG cancer clinical trials.
1543 Background: Cancer disproportionately affects older adults. Approximately 60% of cancer diagnoses occur in adults age...
Dynamics of nectin-4 (N4) expression in urothelial carcinoma (UC): Across disease states.
3131 Background: Enfortumab vedotin (EV), which targets N4, has revolutionized advanced UC management. Despite high preval...
Sensitivity detection of colorectal precancerous lesions and cancer by assessing cell-free multimodal chromatin states in plasma.
e15661 Background: Cell-free DNA in blood originates from fragmented chromatin released by dying cells from both healthy a...
Influence of a vertically integrated care system on mortality risks in insured patients by race and ethnicity.
e13559 Background: Vertically integrated health care systems may help reduce racial and ethnic disparities in cancer outco...
Immunotherapy with or after chemoradiotherapy (CRT) vs CRT alone in limited-stage small cell lung cancer (SCLC): Meta-analysis of randomized controlled trials.
e20140 Background: Limited-stage SCLC is treated with curative-intent concurrent chemoradiation (CRT). However, relapse is...
SYNERGY: A phase 1b/2 study of nenocorilant, a selective glucocorticoid receptor antagonist, plus nivolumab in patients with advanced solid malignancies.
TPS2695 Background: Acting through the glucocorticoid receptor (GR), glucocorticoids (GCs) suppress the anticancer immune...
VISTA: Targeted combination immunotherapy for suppression of breast cancer metastasis and recurrence.
1137 Background: Triple-negative breast cancer (TNBC) has limited treatment options and poor outcomes, with ~12% 5-year ov...
Integrated tumor-informed and tumor-agnostic ctDNA molecular residual disease (MRD) assessment with imaging in early breast cancer.
11130 Background: Accurate ctDNA-based MRD detection in early breast cancer is limited by tumor heterogeneity, clonal evol...
Time on treatment for systemic therapies for patients with hormone receptor-positive breast cancer and <i>BRCA1</i> , <i>BRCA2</i> , or <i>PALB2</i> pathogenic variants.
1096 Background: For patients with hormone receptor-positive/HER2- (HR+) metastatic breast cancer and pathogenic variants...
Accuracy and consensus strategies for large language model abstraction of axillary surgery type from a breast cancer oncologic history text.
e13702 Background: Accurate abstraction of axillary surgery from unstructured oncologic history is essential for breast ca...