Journal of Clinical Oncology
Articles in this Issue
Locoregional therapy for hepatocellular carcinoma before transplant: Impact on tumor necrosis, tumor recurrence, and long-term survival.
579 Background: To assess the effectiveness of different pre-transplant loco-regional therapy (LRT) approaches in patients...
Clonal hematopoiesis in GI cancer: Frequent but not a predictor of oxaliplatin neuropathy.
826 Background: Oxaliplatin (OXA) is a cornerstone therapy for gastrointestinal (GI) cancers, but chemotherapy-induced per...
Impact of routine collection of electronic patient-reported outcome measures (ePROMs) coupled with a collaborative care (CC)-based symptom intervention in patients with early-onset colorectal cancer (eoCRC).
64 Background: The incidence of eoCRC (diagnosed at age <50) is increasing. We have previously shown higher rates of se...
Conditional survival after surgical resection of well-differentiated pancreatic neuroendocrine tumors: A NDCB analysis.
631 Background: Surgical resection remains the standard treatment for low-grade pancreatic neuroendocrine tumors (PanNETs)...
A phase 2 study to investigate the efficacy and safety of acoustic cluster therapy with modified FOLFIRINOX in patients with locally advanced pancreatic cancer.
TPS795 Background: Patients with advanced pancreatic ductal adenocarcinoma (PDAC) face limited treatment options due to th...
Neoadjuvant adebrelimab plus SOX and nab-paclitaxel in resectable locally advanced gastric and gastroesophageal junction adenocarcinoma: A multicentre, single-arm, prospective phase II trial.
344 Background: We report preliminary results from an ongoing single-arm phase II clinical trial evaluating neoadjuvant ad...
Peptide receptor radionuclide therapy (Lu-177 PRRT) in neuroendocrine tumors (NET) over 16 years: Single institution experience.
628 Background: Peptide receptor radionuclide therapy (PRRT) is one of the standard treatments for unresectable or metasta...
Real-world outcomes for pembrolizumab in MSI-high (MSI-H) advanced colorectal cancer (CRC).
223 Background: 5-year follow-up data from the KEYNOTE-177 trial have demonstrated an overall survival (OS) benefit for pe...
Design of a hybrid site and decentralized clinical research study of an early detection blood test for colorectal cancer.
TPS245 Background: Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related...
Total neoadjuvant treatment in locally advanced rectal cancer: A retrospective multicentre cohort analysis in three cancer centres in Brazil.
77 Background: Total neoadjuvant therapy (TNT) improves overall survival (OS) while maintaining local recurrence-free surv...
GATA6 expression with CA19-9 levels as biomarkers in resectable pancreatic adenocarcinoma treated with neoadjuvant modified FOLFIRINOX in the NeoPancONE trial.
772 Background: The increasing use of neoadjuvant systemic therapy for resectable pancreatic adenocarcinoma (rPDAC) highli...
Pathologic determinants of ctDNA-shedding in colorectal cancer metastases.
183 Background: In colorectal cancer (CRC), the concordance of genomic alterations between plasma-derived ctDNA and matche...
Antibody-mediated blockade of gremlin-1 in combination with gemcitabine or MEK inhibition in a genetically engineered mouse model of pancreatic cancer.
705 Background: The tumor microenvironment encompasses complex interactions between cancer cells, fibroblasts, and immune...
Clinical significance of serum CA125 kinetics as an early predictor of tumor progression in pancreatic cancer patients.
768 Background: Serum carbohydrate antigen 125 (CA125) is a well-established marker for the diagnosis of ovarian cancer. H...
A randomized phase II trial of medical cannabis to reduce symptom burden in patients with newly diagnosed advanced colorectal cancer (CANCOL).
TPS252 Background: Patients with advanced colorectal cancer often experience persistent and severe symptom burden. Medical...
Long-term sexual health and post-treatment issues among female survivors of anal cancer.
8 Background: Data on sexual health outcomes and quality of life in long-term female survivors of anal cancer are limited....
Physical activity and molecular residual disease (MRD) in stage III colon cancer: Findings from CALGB (Alliance)/SWOG 80702.
163 Background: Being physically inactive is an independent predictor of poor outcomes in patients with stage III colon ca...
A pilot study of mobile application–based exercise and nutrition interventions for gastrointestinal cancer patients with low muscle mass during chemotherapy.
827 Background: Sarcopenia is linked to poor prognosis in gastrointestinal (GI) cancer patients receiving chemotherapy. Th...
Inappropriate use of tumor markers for GI cancer screening in asymptomatic patients: A systematic review and proposed follow-up framework.
804 Background: Serum tumor markers such as carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9), and alpha...
Test your biomarkers: Real-world perspectives and patient-reported outcomes on biomarker testing from the gastric cancer patient community.
303 Background: Biomarker advancements are reshaping cancer care in the United States and globally, yet disparities and ba...
Use of a vaginal dilator during chemoradiation for anal cancer to mitigate toxicity.
9 Background: Women with anal cancer are at risk of developing urinary and sexual treatment-related toxicity due to radiat...
Treatment patterns and clinical outcomes of metastatic gastric cancer: Real-world evidence from retrospective electronic medical records data.
329 Background: Five-year survival of patients with metastatic gastric cancer (mGC) is poor. Tumor characteristics, timing...
Toripalimab plus hepatic artery infusion chemotherapy in hepatocellular carcinoma patients of Barcelona Clinic Liver Cancer stage C: A biomolecular exploratory, phase II trial.
536 Background: Hepatic arterial infusion chemotherapy (HAIC), and immune checkpoint inhibitors showed promising results f...
Survival benefit of nutritional support in advanced gastric cancer patients receiving chemotherapy: A propensity score–matched study.
354 Background: Malnutrition is highly prevalent among patients with advanced gastric cancer (AGC) and is known to impair...
Longitudinal study on the influence of physical activity in managing cancer-related fatigue in patients with colorectal cancer.
16 Background: Cancer-related fatigue (CRF) is a prevalent and debilitating symptom among patients with colorectal cancer....