Journal of Clinical Oncology
Articles in this Issue
Comparison of weekly docetaxel regimens in prostate cancer: A systematic review and network analysis.
e17104 Background: Docetaxel is one of the most widely used drugs for chemotherapy, both indicated for early onset and metastatic hormone-sensitive prosta...
Image harmonization for PD-(L)1 immune checkpoint inhibitor response prediction using radiomic features and deep learning in advanced NSCLC.
e13689 Background: Machine learning models using radiomic features have demonstrated predictive and prognostic value in oncology applications. One challen...
JSKN003, a biparatopic anti-HER2 antibody drug conjugate (ADC), in the treatment of platinum-resistant ovarian cancer (PROC): Updated findings from two clinical trials.
5557 Background: JSKN003 is a biparatopic HER2-targeting ADC conjugated to a topoisomerase Ⅰ inhibitor with an average DAR...
Magnetic resonance imaging–based deep learning for predicting EGFR mutations in metastatic non-small cell lung cancer: A systematic review and meta-analysis.
e14008 Background: Lung cancer is the most common cancer to metastasize to the brain. Identifying the EGFR mutation is critical for determining treatment...
Long-term outcomes of patients surviving beyond 2 years post–allogeneic stem cell transplantation.
6508 Background: Advances in hematopoietic stem cell transplantation (HSCT) have been driven by progress in supportive care, conditioning regimens, and gr...
Strategic planning to transform pancreatic cancer care: A comprehensive interdisciplinary roadmap.
e13570 Background: Comprehensive interdisciplinary coordinated care is essential for optimizing guideline-concordant treatment and achieving efficient, hi...
Mammographic screening and time to breast cancer diagnosis among immigrants and long-term residents in Ontario.
e12572 Background: Breast Cancer is the most common in women globally and among Canadian women. We explored differences in screening rates and the time to...
Early detection of renal cell carcinoma: A novel cfDNA fragmentomics-based liquid biopsy assay.
4534 Background: Renal cell carcinoma (RCC) is a leading cause of cancer-related mortality, with a rapidly rising global incidence. Early detection greatl...
Development of a highly sensitive ctDNA assay to map the evolution of metastatic breast cancer.
e13048 Background: Treatment of metastatic (met) breast cancer (mBC) remains challenging due to tumor evolution, where tumors may acquire additional somat...
Dietary compounds and patterns associated with immune checkpoint inhibitor (ICI) outcomes in advanced non-small cell lung cancer (NSCLC).
2567 Background: The gut microbiome is a modulator of ICI activity. Diet is among the most important factors influencing the gut microbiome. We previously...
Comparative clinical and molecular outcomes of first, second, and third-generation tyrosine kinase inhibitors in chronic myeloid leukemia: A comprehensive Bayesian network meta-analysis.
e18566 Background: Tyrosine kinase inhibitors (TKIs) are highly effective for chronic myeloid leukemia (CML) carrying the BCR-ABL fusion gene. The advent...
Ivonescimab (PD-1/VEGF bispecific antibody) combined with HAIC for first-line treatment of unresectable hepatocellular carcinoma (uHCC): A prospective, single-arm phase II study.
e16212 Background: The combination of systemic therapies and hepatic arterial infusion chemotherapy (HAIC) has shown promising results in treating unresec...
Examining the relationship between multi-agent immunosuppressive therapy for immune-related adverse events (irAE) and infectious complications.
2658 Background: Treatment of severe irAEs with multiple immunosuppressive therapies (ISTs) decreases the morbidity and mortality of these conditions. Nev...
Utilization and cost implications for collection and storage of excess autologous hematopoietic stem cells in patients with multiple myeloma.
7520 Background: Treatment for transplant-eligible patients with multiple myeloma (MM) is typically induction therapy followed by autologous hematopoietic...
Ipilimumab/nivolumab versus standard of care in non-clear cell renal cancer: Results of the SUNNIFORECAST trial and potential role of the CPS score and tumor nephrectomy.
4522 Background: Non-clear cell renal cancers (nccRCC) are a rare and heterogeneous group of >20 histological and molecular defined entities. Due to th...
Tumor lysis syndrome in lung cancer: A systematic review.
e24044 Background: Lung cancer (LC) is the leading cause of cancer-related mortality globally. Tumor lysis syndrome (TLS), seen predominantly in hematolog...
Implementation and evaluation of multi-cancer early detection testing at the Dana-Farber Cancer Institute: A retrospective analysis of clinical outcomes and diagnostic pathways.
11159 Background: Early detection and interception of cancer is a growing field at the intersection of primary care and oncology. Technological innovation...
Outcomes with KRAS G12C inhibitors in metastatic colorectal cancer: A systematic review and meta-analysis.
e15544 Background: KRAS G12C inhibitors are potential treatment options for patients with KRAS G12C mutated colorectal cancer (CRC) patients, who make up...
Advancing liquid biopsy with qPCR validation: A machine learning-based model for lung cancer detection.
e20025 Background: Lung cancer remains a leading cause of cancer-related mortality worldwide. Early detection significantly improves survival rates. In ou...
Clinical and biological patterns of breast cancer recurrence in young women: A US population-based study.
e12571 Background: Breast cancer (BC) in young women is characterized by distinct clinical and molecular features, frequently presenting with more aggress...
Association of hormone therapy usage with adverse cardiovascular events in prostate cancer patients of the All of Us Research Programcohort.
5021 Background: Hormone therapies (HT) such as GnRH agonists, GnRH antagonists, and/or anti-androgens have led to improved overall survival for prostate...
A randomised clinical trial to improve healthy lifestyle adherence in prostate cancer patients undergoing radiotherapy (Microstyle study).
5105 Background: The standard non-surgical approach for localized Prostate Cancer (PCa) is radiotherapy (RT) but PCa patients may experience worsening of...
Second interim analysis of CABONEN: An international, multicenter phase II trial investigating cabozantinib in patients with advanced, low proliferative NEN G3.
e16351 Background: The prognosis of patients with neuroendocrine neoplasia (NEN) depends mainly on the proliferation index (Ki67). Patients with NEN G1 an...
Exploration of neoadjuvant therapy regimens and prediction of immune effects for HER2-positive locally advanced breast cancer.
e12614 Background: Neoadjuvant therapy (NAT) is currently the main strategy for treating locally advanced HER2-positive breast cancer. However, the hetero...
A cluster analysis of clinician distress trajectories when caring for seriously ill hospitalized patients.
9012 Background: Millions of Americans are hospitalized every year; many of whom are seriously ill with one or more co-morbidities. Clinicians, including...