Journal of Clinical Oncology
Articles in this Issue
Venous thromboembolism among cancer patients receiving chimeric antigen receptor-T cell therapy.
11179 Background: Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of advanced cancers. Although, immune side effects (IC...
Validation of generative AI models’ performance on patient education quizzes: Hormone-related symptoms of cancer care.
e13881 Background: To evaluate the clinical reliability and accuracy of generative AI models when answering patient-level educational quizzes on hormone-r...
ABLE-41, a real-world evidence study for bladder cancer patients treated with nadofaragene firadenovec: Baseline patient characteristics and demographics.
e16608 Background: Nadofaragene firadenovec-vncg is the first FDA-approved intravesical nonreplicating adenoviral vector-based gene therapy which delivers...
Factors impacting treatment with a CDK4/6i in first line metastatic HR+/HER2- breast cancer patients.
e13079 Background: The inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6i), abemaciclib, palbociclib and ribociclib, are indicated for the treatment...
Safety and efficacy of immune checkpoint inhibitors in solid organ transplant recipients: A systematic review and individual patient data meta-analysis.
2511 Background: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but pose unique challenges in solid organ transplant (SOT) recip...
An open-label phase 1/2 study of DCC-3009 monotherapy in patients with advanced gastrointestinal stromal tumor.
TPS11580 Background: Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract. KIT and plate...
Connecting clinical trials with patients using patient navigation: A scoping review.
e13560 Background: Patient navigation is a promising strategy to improve access to cancer care, but the evidence supporting its role in increasing access...
Genomic characterization of STAS in stage 1 EGFR-mutated NSCLC and prognostic implications.
8029 Background: Spread through air spaces (STAS) is a poor prognostic factor and was recently introduced as a histologic descriptor in the TNM edition 9...
Discrepancies between germline and somatic laboratories in the reporting of germline cancer predisposition variants.
10568 Background: Individuals with a cancer diagnosis may not qualify for germline testing to identify cancer predisposition variants due to restrictive t...
Efficacy and safety of cafelkibart (LM-108), an anti-CCR8 monoclonal antibody, in combination with anti-PD-1 therapy in patients with pancreatic cancer: Results from phase 1/2 studies.
4010 Background: Targeting tumor-infiltrating Tregs presents a promising strategy to overcome resistance to immunotherapy in cancer treatment. LM-108 is a...
Social needs and systemic inflammation associated with cancer survival among a historically marginalized population.
e13797 Background: Challenges with social determinants of health (SDoH) have been shown to increase the risk of delays in cancer treatment initiation and...
Allogeneic hematopoietic stem cell transplantation in T-cell acute lymphoblastic leukemia adults in complete remission: A systematic review and meta-analysis.
6559 Background: There is limited data on the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HCT) in T-cell acute Lymphoblastic Leuk...
The efficacy and safety of Surufatinib monotherapy as a third-line treatment for advanced hepatocellular carcinoma: A single-arm, open-label, multi-center phase II study.
e16209 Background: Hepatocellular carcinoma (HCC) is an aggressive liver cancer with limited treatment options, particularly in advanced stages. Surufatin...
Clinical characteristics of young-onset breast cancer and the role of germline pathogenic variants.
10582 Background: Breast cancer is the most common cancer in young women, with an increasing incidence over the past two decades. This study aims to evalu...
Predictive value of circulating methylated Septin 9 for pathologic complete response to neoadjuvant chemoradiation therapy in locally advanced rectal cancer.
e15649 Background: Prediction of pathologic complete response (pCR) after neoadjuvant radio-chemotherapy (nCRT) is of great importance for locally advance...
Comparative transcriptomic analysis to identify similarities and therapeutic vulnerabilities in olfactory neuroblastoma (ONB), sinonasal neuroendocrine carcinoma (SNEC) and sinonasal undifferentiated carcinoma (SNUC).
6095 Background: ONB, SNEC and SNUC are rare sinonasal epithelial/neuroepithelial tumors, underserved by clinical trials, with few treatments available de...
The Promise study: A presurgical randomized clinical trial of CE/BZA vs placebo in postmenopausal women with ductal carcinoma in situ.
512 Background: Conjugated estrogen/bazedoxifene (CE/BZA), the first tissue selective estrogen complex, was developed as a...
Ways to accelerate the local implementation and adoption of the homologous recombination deficiency (HRD) testing in India.
e17596 Background: AssessingHomologous Recombination Deficiency (HRD) is crucial for ovarian cancer patients to benefit from poly(ADP-ribose polymerase) i...
Phase I study to evaluate the safety and efficacy of switchable CAR-T cell therapy with FY001 and CART001 in patients with refractory CD20-positive B-cell non-Hodgkin lymphoma (EPOC1803).
7031 Background: CD19-targeted CAR-T cell therapy has shown remarkable efficacy against relapsed/refractory B-cell non-Hodgkin lymphoma (r/r B-NHL). Howev...
Predicting high-risk group according to Oncotype DX recurrence score using dynamic contrast-enhanced breast MR with temporal radiomic features.
e12533 Background: Temporal radiomic features (TRF) extracted from dynamic contrast-enhanced breast MR (DCE-MR), which provide important information about...
FES and FDG PET imaging performance comparison for potential use in biology-guided radiotherapy for breast cancer.
e12575 Background: SCINTIX biology-guided radiotherapy (BgRT) uses F18-FDG emissions from lung and bone tumors to direct radiotherapy beamlets almost in r...
Real-world zanubrutinib treatment patterns in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) among US community oncology patients with prior acalabrutinib therapy.
e23265 Background: Despite higher selectivity of the second-generation Bruton tyrosine kinase inhibitor (BTKi) acalabrutinib (acala) compared with the fir...
Osteoradionecrosis as a complication following intensity-modulated radiation therapy or proton therapy in the treatment of oropharyngeal carcinoma.
6066 Background: Osteoradionecrosis (ORN) is a late complication of head and neck radiotherapy (RT) that negatively impacts survivorship. Although there i...
Clinical outcomes of cytomegalovirus infection among patients receiving chimeric antigen receptor T cell therapy.
7021 Background: Chimeric antigen receptor T (CAR-T) cell therapy is a transformative treatment for hematologic malignancies, including multiple myeloma (...
Eliciting the patient perspective: Using design-thinking methodology to assess the utility of incorporating narrative medicine tools in inpatient cancer.
e23212 Background: Integrating narrative medicine (NM) into oncologic care presents a promising opportunity to enhance patient-centered care by addressing...