Journal of Clinical Oncology
Articles in this Issue
The role of IPSS-m in predicting survival and relapse after allogeneic HSCT for MDS: A single center experience.
e18577 Background: Next-generation sequencing (NGS) has revolutionized the diagnosis and management of Myelodysplastic Neoplasms (MDS), but the prognostic...
Intrathecal deferoxamine in patients with leptomeningeal metastases: Phase 1a analysis.
2032 Background: Leptomeningeal metastases (LM), the spread of cancer to the cerebrospinal fluid (CSF), is associated with high morbidity and mortality. L...
Hydroxyurea vs. hypomethylating vs. other agents in chronic myelomonocytic leukemia: A retrospective inspection of treatment strategies among 457 Mayo Clinic patients.
6579 Background: Treatment strategies in chronic myelomonocytic leukemia (CMML) are not standardized and include hydroxyurea (HU) and hypomethylating agen...
Randomized study evaluating optimal dose, efficacy and safety of E7386 + lenvatinib versus treatment of physicians’ choice in advanced/recurrent endometrial carcinoma previously treated with anti–PD-(L)1 immunotherapy.
TPS5632 Background: E7386 is an inhibitor of protein-protein interaction between β-catenin and CREB binding protein (CBP). E7386 + lenvatinib has demonstr...
Changes in the degree of satisfaction and quality of life in breast cancer patients who are candidates for breast conservation but opted for mastectomy: A single-center prospective study.
584 Background: Randomized trials have shown that breast-conserving surgery (BCS) and total mastectomy (TM) provide comparable survival outcomes for early...
Real world experience of melphalan/hepatic delivery system with circulating tumor DNA (ctDNA) monitoring in patients with metastatic uveal melanoma.
e21520 Background: Percutaneous hepatic perfusion (PHP) is a repeatable procedure that delivers melphalan loco-regionally with a hepatic delivery system (...
Disparities in prostate cancer (PCa) outcomes after primary prostatectomy among Latinos.
e17149 Background: PCa is the most frequently diagnosed malignancy among Latino men (Globocan, 2022). Latino patients with PCa experience a disproportiona...
Retrospective analysis of the efficacy and safety of disitamab vedotin (RC48) in Chinese patients with HER2-positive or HER2-low metastatic breast cancer.
e13002 Background: Antibody-drug conjugates (ADCs) have emerged as a novel and effective treatment option for breast cancer patients with varying levels o...
Next-generation U-Net Encoder: Decoder for accurate, automated CTC detection from images of peripheral blood nucleated cells stained with EPCAM and DAPI.
3061 Background: Direct circulating tumor cell (CTC) detection is a promising biomarker for early cancer detection and monitoring. Traditional fluorescenc...
Perioperative systemic therapy for resectable colorectal peritoneal metastases: A multicenter randomized phase 3 trial (CAIRO6).
3505 Background: In patients with resectable colorectal peritoneal metastases who qualify for cytoreductive surgery with h...
Ethnic and socioeconomic disparities in survival outcomes among patients under 65 years with intrahepatic cholangiocarcinoma: A SEER analysis.
e13745 Background: Intrahepatic cholangiocarcinoma (iCCA), the second most prevalent primary liver tumor, is associated with high mortality rates despite...
PSA and alkaline phosphatase changes in the EORTC-1333 PEACE-3 study evaluating the addition of six cycles of radium 223 in metastatic castration-resistant prostate cancer (mCRPC) starting enzalutamide.
5062 Background: The EORTC/UNICANCER/CTI/CUOG/LACOG Peace 3 showed that adding Ra233 to enzalutamide significantly improves investigator-assessed progress...
Effectiveness and safety of combined therapy with pemetrexed and bevacizumab in recurrent and metastatic cervical cancer.
e17532 Background: In Uzbekistan, cervical cancer ranks third among all oncological diseases, with an incidence rate of 5.1 cases per 100,000 population i...
Risk patterns for second primary malignancies among human papillomavirus (HPV)–associated first primary cancer survivors in the United States.
10516 Background: Previous studies have shown an increased risk of second primary malignancies (SPMs) among human papillomavirus (HPV)-associated first pr...
Increasing mortality burden in patients with hypertension and colorectal cancer in the United States from 1999 to 2020.
e15646 Background: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the United States (US) in 2024. With a multifactorial e...
Clinical outcomes and epidemiology of acute ischemic stroke in breast cancer patients admitted to U.S. hospital.
e13165 Background: Breast cancer (BCA) patients face an elevated risk of acute ischemic stroke (AIS) due to mechanisms such as cancer-associated hypercoag...
The socioeconomic burden of ovarian cancer in 11 countries.
e17540 Background: Globally, over 900,000 women have been diagnosed with ovarian cancer in the last five years with approximately 7 of every 10 women diag...
Clinical approaches to early detection of colon adenocarcinoma: Evaluating conventional and biomarker-based strategies.
e15625 Background: Colon adenocarcinoma is the most common subtype of colorectal cancer, originating from glandular cells in the colon where malignant cel...
Germline genetic testing among patients with pancreatic cancer (PC): A Pancreatic Cancer Action Network (PanCAN) patient survey.
10594 Background: Universal germline genetic testing for PC is endorsed by multiple professional organizations like the National Comprehensive Cancer Netw...
Frailty and days at home in the year after surgery for ovarian cancer: A patient centered outcome for older adults.
e13843 Background: Ovarian cancer debulking surgery is associated with improved survival but also with significant perioperative morbidity. Days at home (...
First in human phase 1 dose escalation and expansion clinical trial to evaluate the safety, pharmacokinetics and antitumor activity of intravenous AROG4-01 in patients with advanced solid tumors.
TPS3176 Background: AROG4-01 is a synthetic compound with a first-in-class mechanism of action, targeting complex secondary structural elements in mRNA, i...
Impact of homologous recombination repair gene mutations on survival in metastatic castration-sensitive prostate cancer (mCSPC) from an observational database.
e17098 Background: Mutations in homologous recombination repair genes (HRRm) are known to increase the aggressiveness of prostate cancer (PCa). However, t...
Ongoing phase 1/2 trial of the hematopoietic progenitor kinase 1 (HPK1) inhibitor NDI-101150 as monotherapy or in combination with pembrolizumab: Clinical safety and efficacy update in clear cell renal cell carcinoma (ccRCC).
4537 Background: NDI-101150 is a potent and selective oral inhibitor of HPK1, a serine/threonine kinase that acts as a negative regulator of immune cell f...
Factors associated with survival of central nervous system tumors in a population-based cancer registry.
e14025 Background: Population-Based Cancer Registries (PBCRs) are a primary source of information on cancer incidence and survival within a specific regio...
Improving pain management knowledge among hospice family caregivers: A randomized controlled trial.
12032 Background: Poor pain management in home hospice settings is often due to family caregivers not adhering to analgesic regimens. Healthcare technolog...