Journal of Clinical Oncology
Articles in this Issue
Early onset colorectal cancer in Pakistan: Frequency and association with stage and grade.
e15709 Background: The disproportionate rise in early onset colorectal cancer (CRC) constitutes a critical public health issue. The objective of the study...
Incidence of concurrent pathogenic variants in <i>BRCA1</i> breast cancer patients.
10586 Background: Over the years, advancements in genetic testing have led to an expansion in the number of detectable mutations. This progress has enable...
Trends and disparities in cerebrovascular disease–related mortality in older adults with colorectal cancer: A nationwide retrospective analysis.
e22561 Background: Older cancer patients, particularly those with colorectal cancer (CRC), are at increased risk for incidence and complications of cerebr...
Impact of telemedicine on access to care in surgical oncology clinics: Distance and time to visit analysis for new patients at a multispecialty cancer center.
e23345 Background: Telemedicine enables patients to attend visits remotely and is associated with shorter wait times (i.e. scheduling-to-appointment durat...
A comprehensive analysis of primary malignant brain tumors radiotherapy in a low-resourced country: A single-institution retrospective study.
e14035 Background: The purpose of this study is to investigate radiation treatment of primary malignant brain tumors in a country with limited resources a...
Treatment outcomes in patients with myelofibrosis and platelets ≥50 x10 <sup>9</sup> /L treated with pacritinib in the United States.
e18585 Background: Pacritinib (PAC), a JAK1 sparing JAK2/IRAK1/ACVR1 inhibitor, has shown clinically significant spleen volume and symptom reduction in pa...
Association between hemoglobin levels and cancer risk: An analysis using NHANES 2017–2020 data.
e22588 Background: Hemoglobin (Hb) levels have been implicated in various malignancies. Anemia serves as an early indicator for leukemia, conversely, elev...
Enhancing tumor microenvironment composition to favor PD-1 inhibition via pretreatment with low-dose per fraction radiotherapy in a mouse breast cancer model.
e14556 Background: Despite recent advancements with immune checkpoint inhibitors, a significant proportion of patients, particularly those with triple-neg...
A phase 1 first-in-human study evaluating safety, pharmacokinetics, and efficacy of ABBV-291, a CD79b-targeting antibody-drug conjugate, in patients with relapsed/refractory B-cell non-Hodgkin lymphoma.
TPS7093 Background: Chemoimmunotherapy successfully treats ~60% of patients (pts) with diffuse large B-cell lymphoma (DLBCL), the most common form of B-ce...
Impact of vascular microenvironment on prognosis in hepatocellular carcinoma: A quantitative feature analysis.
e16293 Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality globally. The vascular component of the tumor microenviro...
Phase 3 study of benmelstobart in combination with chemotherapy followed by sequential combination with anlotinib for the first-line treatment of locally advanced or metastatic squamous non-small cell lung cancer (sq-NSCLC).
8514 Background: PD-1/ PD-L1 inhibitors plus platinum-based chemotherapy is the standard first-line therapy for locally advanced or metastatic sq-NSCLC. I...
Observational study of prevalence, management, and outcomes of synchronous oligometastatic non-small cell lung cancer.
e20516 Background: Oligometastatic non-small cell lung cancer (NSCLC), characterized by one to five metastatic lesions in up to three organs, represents a...
Exploring racial disparities in biliary tract cancer with sepsis.
e16185 Background: Biliary tract cancers (BTCs) account for 3% of all cancers. In 2021, the incidence of BTCs was 15.8 per 100,000 among Hispanics (HP), 1...
The association of ctDNA with recurrence in patients with stage II-IV colorectal cancer: The β-CORRECT study.
3590 Background: CRC is a leading cause of cancer-related mortality globally. Detection of molecular residual disease (MRD) is an early indicator of recur...
Outcomes of split-dose lymphocyte-adjusted rabbit ATG in allogeneic stem cell transplant recipients.
e18560 Background: Despite advances in graft versus host disease (GVHD) prevention, rabbit antithymocyte globulin (rATG) remains a guideline-based option...
Exploratory analysis of responders from the phase 3 EV-302 trial of enfortumab vedotin plus pembrolizumab (EV+P) vs chemotherapy (chemo) in previously untreated locally advanced or metastatic urothelial carcinoma (la/mUC).
4502 Background: EV-302/KEYNOTE-A39 (NCT04223856) showed significant PFS and OS benefits for pts with previously untreated la/mUC treated with EV+P vs che...
Impact of immune checkpoint inhibitor (ICI)-associated autoimmune hemolytic anemia (AIHA) on mortality in cancer patients: A retrospective analysis.
2649 Background: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but can cause serious immune-related adverse events; including r...
Prognostic and predictive role of HLA supertypes in pMMR mCRC patients receiving FOLFOXIRI/bev ± atezolizumab in the AtezoTRIBE study.
3547 Background: The HLA system plays a crucial role in the development of the adaptive immune response, influencing antigen presentation and T-cell-media...
Digital profiling of tumor-derived extracellular vesicle-RNA: A sensitive approach for early detection of EGFR mutations in osimertinib-resistant non-small cell lung cancer.
e20076 Background: Osimertinib resistance in EGFR-mutant non-small cell lung cancer (NSCLC) patients presents a significant challenge due to limited post-...
United States treatment pattern response to carboplatin and cisplatin shortages.
11088 Background: In response to cisplatin (2/10/23) and carboplatin (4/28/23) shortages, national guidelines recommended prioritizing cisplatin and carbo...
Machine learning–driven approaches for predicting T-cell–mediated immunity and beyond.
2588 Background: Recognition of peptides presented by the major histocompatibility complex (MHC) through the T cell receptor (TCR-pMHC) is crucial for T c...
Effect of chemotherapy drug cisplatin on the efficacy of B7H3 CAR-T cells in treating melanoma by increasing target antigen density.
e21562 Background: B7H3 is overexpressed in multiple types of solid tumors, including melanoma, making it an ideal target for chimeric antigen receptor (C...
Efficacy and safety of LM-302 (anti-claudin 18.2 ADC) in combination with anti-PD-1 therapy for advanced gastric, gastroesophageal junction cancer and esophageal adenocarcinoma: Early-phase study results.
4039 Background: Claudin 18.2 (CLDN18.2), a tight junction protein highly expressed in gastric and gastroesophageal junction (GEJ) cancers, has emerged as...
Mayhem under the microscope: T cell cytotoxicity and serial killers captured in situ.
2540 Background: Developing a deeper understanding of the dynamics of immune cell-mediated cytotoxicity is critical to advancing immunotherapy and cell th...
Concurrent chemoradiotherapy in locally advanced lung cancer with cisplatin-etoposide or carboplatin-paclitaxel: An institutional analysis.
e20042 Background: In patients with unresectable locally advanced non-small cell lung cancer (NSCLC), chemotherapy given concurrently with radiation (CRT)...