Journal of Clinical Oncology
Articles in this Issue
Combined (SoliQ) molecular profiling using whole exome sequencing in advanced HNSCC at baseline: Lessons learned for prognostication and treatment planning.
e18025 Background: HNSCC imparts rising incidence and mortality rate worldwide, due to lack of information regarding spatial and temporal heterogeneity of...
Retrospective single-institution application of a deep learning–based radiomic score in metastatic NSCLC: Potential impact on first-line treatment decisions and outcomes.
e20608 Background: Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis are standard of care for metastatic non-small cell lung cancer (mNSCL...
National trends in disability-adjusted life years (DALYs) of pancreatic cancer among individuals aged 70 and older across 204 countries (1990-2021): A global burden of disease study.
e22572 Background: Pancreatic cancer is a highly lethal malignancy that disproportionately impacts older populations, contributing significantly to global...
Omission of elective neck irradiation in pT3-T4 oral squamous cell carcinoma with a pN0 neck: Impact on regional control and overall survival.
e18091 Background: Postoperative radiotherapy is commonly indicated for the treatment of locally advanced oral squamous cell carcinoma (OSCC). However, fo...
Outcomes of patients with technically resectable stage III non-small cell lung cancer treated with concurrent chemoradiation followed by durvalumab consolidation.
e20013 Background: Patients with early stage non-small cell lung cancer (NSCLC) benefit from surgical resection when feasible. The PACIFIC trial showed th...
Sepsis-related outcomes and the healthcare burden in esophageal cancer patients with atrial fibrillation: A national database study.
e16002 Background: Among solid tumors, esophageal cancer (EC) is notably associated with atrial fibrillation (AF). The development of AF in EC is influenc...
A 25-year perspective on tongue cancer-related mortality: Nationwide trends and disparities in the United States.
e22543 Background: Tongue cancer represents a significant proportion of oropharyngeal cancers. Despite advances in treatment, disparities in mortality per...
Should radiotherapy be considered for the initial treatment of ovarian cancer brain metastases? Findings from a 12-year multicenter retrospective study.
e17541 Background: Ovarian cancer brain metastases (OCBM) are rare and have poor prognosis, with limited clinical guidelines. This study aims to identify...
Incidence of brain metastases in lung cancer patients with high PD-L1 expression (>50%) compared to low PD-L1 expression (<1%).
e20533 Background: Programmed cell death protein 1 (PD1) is a cell membrane receptor that primarily works to activate T cells and to inhibit the apoptosis...
Combined hepatocellular cholangiocarcinoma: A population-based retrospective study.
e16291 Background: In 2011, the Ministry of Health, Labor and Welfare started providing data from the National Database of Health Insurance Claims and Spe...
Sosimerasib monotherapy in patients with previously treated KRAS G12C–mutated non-small cell lung cancer: Primary results of a phase 2 study.
8520 Background: KRAS G12C mutation is a poor prognostic factor for Non-Small Cell Lung Cancer (NSCLC). Sosimerasib is a novel potent and highly selective...
Circulating tumor DNA (ctDNA) dynamics in liver-limited metastatic colorectal cancer (mCRC) patients resected after first-line systemic treatment.
3544 Background: Liver-limited disease (LLD) occurs in 20-30% of metastatic colorectal cancer (mCRC) patients. Although 20-30% of patients who undergo res...
Unveiling the power of PARP inhibitors: A meta-analysis on newly diagnosed advanced ovarian cancer maintenance therapy.
e17573 Background: The treatment of ovarian cancer with poly (adenosine diphosphate-ribose) polymerase (PARP) inhibitors (PARPi) is undergoing continuous...
Lymphatic mapping to the inguinal region in patients with lower extremity melanoma undergoing radical inguinal lymph node dissection: A retrospective cohort study.
e21567 Background: Radical inguinal lymph node dissection (rILND) is the standard procedure for malignant melanoma (MM) patients with clinically positive...
Impact of palliative chemotherapy in hospitalized patients with advanced solid tumors.
11150 Background: The role of palliative chemotherapy (PC) in patients with advanced solid tumors and poor performance status (PS) remains uncertain since...
Final results of a phase 2 study of HDACi chidamide and PD-1 inhibitor for advanced urothelial carcinoma after platinum therapy.
4563 Background: Epigenetic dysregulation is commonly correlated with the pathogenesis and development in urothelial carci...
Treatment patterns and out-of-pocket cost after CAR-T cell therapy in commercially insured patients with hematologic malignancies: A real-world US study.
11045 Background: Chimeric Antigen Receptor T (CAR-T) cell therapy has improved outcomes in hematologic malignancies since its FDA approval in 2017. Howev...
Linvoseltamab (LINVO) + carfilzomib (CFZ) in patients (pts) with relapsed/refractory multiple myeloma (RRMM): Initial results from the LINKER-MM2 trial.
7513 Background: LINVO, a T-cell redirecting BCMA×CD3 bispecific antibody, has demonstrated high efficacy and generally manageable safety in triple-class...
Perfume trial: Phase II trial of binimetinib in patients with <i>BRAF</i> fusion-positive low-grade glioma or pancreatic cancer.
TPS3188 Background: BRAF fusion was reported to be a rare mutation found in 0.3% of all solid tumors, but a high percentage of BRAF fusion has...
A systemic trend analysis of young onset esophageal cancer in American population, 2012-2021.
e16098 Background: Esophageal adenocarcinoma (EAC) is a rapidly growing cancer in the United States. Although often associated with older populations, the...
A prospective randomized controlled study about oral nutrition supplement in local advanced nasopharyngeal carcinoma patients: An update of long-term survival.
e18018 Background : Radiotherapy will aggravate malnutrition of nasopharyngeal carcinoma (NPC) patients and influence the prognosis. However,...
The addition of abemaciclib to endocrine therapy versus endocrine therapy alone in HR+/HER2− advanced breast cancer: A meta-analysis.
e13167 Background: Abemaciclib represents a significant therapeutic advancement in the treatment of advanced metastatic breast cancer. As a selective prot...
Long-term safety and efficacy of sotorasib plus panitumumab and FOLFIRI for previously treated <i>KRAS</i> G12C-mutated metastatic colorectal cancer (mCRC): CodeBreaK 101 (phase 1b).
3506 Background: In the phase 3 CodeBreaK 300 trial (NCT05198934), the combination of sotorasib (KRAS...
Novel dynamic circulating biomarkers for predicting therapeutic efficacy of PRaG regimen in advanced refractory solid tumors.
2548 Background: Common biomarkers for predicting the efficacy of immune checkpoint inhibitors (ICIs), such as programmed death-ligand 1 (PD-L1) expressio...
Cardiometabolic health in men with prostate cancer under active surveillance following a home-based exercise program—A secondary analysis.
e22617 Background: Prostate cancer (PCa) is the most common cancer affecting men in the US, with cardiovascular disease and neurologic decline being commo...