Journal of Clinical Oncology
Articles in this Issue
Virtual yoga (vYOCAS) intervention for psychological distress: A decentralized digital randomized controlled trial with cancer survivors.
12131 Background: Psychological distress is highly prevalent among cancer survivors, and it interferes with their ability to recover after treatment and r...
The impacts on prognosis of the relationship between decline in renal function associated with pemetrexed and the ratio of pemetrexed administration.
e20623 Background: The KEYNOTE 189 regimen of pembrolizumab + pemetrexed + cisplatin/carboplatin is currently being used as first-line chemotherapy for me...
Impact of neuroradiologists’ input on peer review meetings for CNS radiotherapy treatment planning.
2043 Background: Evidence shows radiologists’ involvement improves planning accuracy, especially in complex anatomical areas. However, their participation...
RIBBON-UM: Treatment individualisation by EBV stratification in nasopharyngeal carcinoma (NPC): A phase 2, multi-arm umbrella platform trial.
TPS6123 Background: Induction chemotherapy (IC) and chemoradiotherapy (CRT) is the current standard of care (SOC) for locoregionally advanced NPC (LA-NPC)...
Real world and Appalachian comparison of axicabtagene ciloleucel and lisocabtagene maraleucel in relapsed/refractory diffuse large B-cell lymphoma.
e19003 Background: Chimeric antigen receptor T-cell therapies targeting CD19, like Axicabatagene ciloleucel (axicel) and Lisocabtagene maraleucel (lisocel...
Validation of metastatic breast cancer (mBC) diagnosis in structured electronic health record (EHR) data vs chart-curated verification using the IntegraConnect Precision-Q (IC PQ) de-identified database.
e23147 Background: Leveraging EHR data to study cancer provides details from physician notes and scanned reports not available in claims data. The IC PQ D...
Trial in progress: Sacituzumab govitecan for the treatment of patients with diffuse pleural mesothelioma.
TPS8123 Background: Diffuse pleural mesothelioma (DPM) is an aggressive malignancy with poor outcomes and only three FDA-approved treatments (all first-li...
Peripheral and cutaneous T-cell lymphomas in the United States: A 21-year mortality analysis (1999-2020).
e19055 Background: Peripheral and cutaneous T-cell lymphomas (PTCL and CTCL) comprise of a vast variety of rare and heterogeneous subtypes of non-Hodgkin...
Landscape of functional DLL3 expression in gastroenteropancreatic neuroendocrine neoplasms (GEP NENs).
4146 Background: Delta-like ligand 3 (DLL3) is an emerging target in multiple neuroendocrine cancers including small cell lung cancer but remains underexp...
Clinical efficacy and safety of cadonilimab in the treatment of advanced gynecological malignancies: A retrospective, real-world study.
e17652 Background: Cadonilimab, recognized as the most rapidly developed Chinese bispecific antibody in the field of cervical cancer, received marketing a...
Efficacy and safety of ribociclib (RIB) + nonsteroidal aromatase inhibitor (NSAI) in NATALEE: Analysis across menopausal status and age.
516 Background: The NATALEE trial demonstrated significant invasive disease–free survival benefit with RIB + NSAI vs NSAI alone in patients (pts) with sta...
Prognostic features and clinical panthological factors of cutaneous malignant melanoma.
e21589 Background: Cutaneous malignant melanoma (CMM), a skin-originating subtype of melanoma, is highly invasive with strong metastatic potential. Acral...
Understanding disparities in survival outcomes for early-onset gastric cancer: A comprehensive multifactorial analysis using SEER database.
e16148 Background: Despite a declining overall incidence of gastric cancer in the United States, Early-Onset Gastric Cancer (EOGC), diagnosed in individua...
The EGFR-TKIs treatment challenge in NSCLC: Changes in survival after COVID-19 infection.
e20538 Background: COVID-19 has emerged as a major public health emergency with long-term impacts, especially on cancer patients who are more susceptible...
Prospective assessment of health-related quality of life in early phase clinical trials.
11118 Background: Early phase clinical trials (EP-CTs) provide patients with access to novel therapeutics once standard of care options are exhausted or n...
Enterprise-level AI screening for oncology trials: Improving patient identification with OncoLLM.
e13706 Background: Comprehensive clinical trial screening for all oncology patients is challenging due to multiple factors...
Comprehensive analysis of clinicopathological features and outcomes of hormone positive breast cancer from a tertiary care centre in India.
e12581 Background: The composite data of clinicopathological features and outcomes in hormone receptor-positive (HR+) breast cancer from a low-middle inco...
Exploring survival outcomes in sarcomatoid hepatocellular carcinomas in the era of immunotherapy.
e16330 Background: Sarcomatoid hepatocellular carcinoma (SHC) is a rare and aggressive variant of hepatocellular carcinoma (HCC), accounting for less than...
Evaluation of surrogate endpoints in muscle-invasive bladder cancer (MIBC): A systematic review and meta-analysis.
4580 Background: Overall survival (OS) is the gold-standard efficacy measure in oncology; however, it can take several years for OS data to mature, partic...
Comparison of dual vs. triple oral metronomic chemotherapy using methotrexate, celecoxib with or without erlotinib in advanced head and neck squamous cell cancer: Real-world data and experience from a tertiary care center.
e18038 Background: The standard of care for unresectable or metastatic advanced head and neck squamous cell carcinoma (HNCSCC) is either immunotherapy or...
Phase 1 trial of exercise as first-line therapy for hormone receptor (HR)–positive advanced breast cancer (TBCRC 054).
1088 Background: Observational studies show post-diagnosis exercise is associated with reduced risk of cancer death in patients with HR-positive breast ca...
Treatment-related changes in salivary CD44 and total protein in patients with oral and oropharyngeal cancer.
e18061 Background: Prior smaller-scale studies have demonstrated elevated salivary CD44 and total protein (TP) in patients with oral cavity and oropharyng...
Ethnic differences in non-metastatic breast cancer outcomes by tumour subtype: Real-world data from the Singapore Joint Breast Cancer Registry.
e13772 Background: Ethnic disparities in breast cancer (BC) are increasingly recognized, with emerging differences among d...
Identification of tissue-resident adaptive NK cells and their association with reduced mortality across diverse solid tumors.
e14555 Background: Natural killer (NK) cells are innate lymphocytes that engage in direct cytotoxic responses against malignant cells and promote pro-infl...
Impact of anti-VEGF therapy duration on KRAS/NRAS WT mCRC survival after anti-EGFR therapy.
e15549 Background: First-line anti-EGFR therapy is one of the choice that improves outcomes in KRAS/NRAS wild-type(WT), but evidence on subsequent anti-VE...