The Journal of Immunology
Articles in this Issue
Unveiling the role of lysosomes in antigen processing and presentation
Abstract Lysosomes drive antigen proteolysis and peptide loading for major histocompatibility complex class II (MHCII) presentation in antigen-presenting cells (APCs), enabling activ...
Delivery of extracellular vesicle–associated microRNA-146a regulates human monocyte phenotype and function
Abstract CCR2+ monocytes are recruited to sites of acute myocardial injury, where they play a critical role in clearing necrotic debris and replenishing the depleted resident macroph...
Semaphorin3E is a novel regulator of germinal center responses in a mouse model of allergic asthma
Abstract Little is known about the role of semaphorin 3E (Sema3E) in B cell responses and immunoglobulin regulation. Our recent data indicate that Sema3e knockout mice have significa...
IgA binding characteristics of golden hamster and ferret Fcα receptors
Abstract Golden hamster (Mesocricetus auratus) and ferret (Mustela putorius furo) are important animal models in studies of human infectious disease. They are used widely to investig...
Metabolic crosstalk between c-Myc and glutamine utilization sustains IgM+ B-cell immunity in teleosts
Abstract B-cell responses rely on a tightly coordinated interplay between transcriptional programs and metabolic reprogramming. Upon activation, B cells remodel their metabolic profi...
Adipose stem cell vesicles reduce bleomycin-induced dermal fibrosis and oxidative stress in scleroderma mice via circ-Zfyve9
Abstract Systemic sclerosis (SSc) is an autoimmune condition affecting several organs. It is identified by thickening of the dermis, connective tissue affected by collagen accumulati...
Innate immune reprogramming of chicken macrophages by sodium butyrate enhances reactive oxygen species–mediated antimicrobial responses in vitro
Abstract In the established model of classical trained immunity, metabolic and epigenetic hubs serve as central integrators of innate memory. While typically associated with proinfla...
Antigen presentation requirements for effective cDC1-based cancer immunotherapy
Abstract Type 1 conventional dendritic cells (cDC1s) are important for generating and sustaining antitumor immunity. Accordingly, the abundance of cDC1s in human tumors correlates wi...
Enforcing mTORC1 activity in therapeutic CD4+ T cells promotes persistence but eventual immune exhaustion
Abstract There is substantial interest in developing novel engineering strategies to promote the sustained metabolic fitness of therapeutic T cells. We previously showed that overexp...
Generation and characterization of a novel MHC-II tetramer for tracking and characterization of toxin B–specific CD4+ T cell responses
Abstract The gastrointestinal pathogen Clostridioides difficile is a major burden for health systems due to high rates of recurrence. C. difficile pathogenesis is mediated by two vir...
Skullcapflavone II alleviates osteoarthritis by inhibiting inflammation and ferroptosis via the SLC7A11/GPX4 signaling pathway
Abstract Osteoarthritis (OA), the most prevalent degenerative joint disease, leads to significant disability in the elderly and is characterized by functional and structural deterior...
TRECing down the source: naive and memory T cell generation in dirty mice and men
Abstract Healthy aging relies on the maintenance of a diverse T cell pool. This diversity is ensured by balancing thymic output, differentiation of naive into memory T cells, T cell...
Fluid shear stress as a co-stimulatory cue to enhance T cell priming and restore activation in cancer patient T cells
Abstract Cancer patient-derived T cells often exhibit impaired activation and functional responsiveness due to chronic antigen exposure and therapy-induced immune dysregulation, limi...
Rapid glycolytic metabolism underpins mucosal-associated invariant T cell functional responses to innate cytokines
Abstract Mucosal-associated invariant T (MAIT) cells express a semi-invariant T cell receptor (TCR) that recognizes bacterial-derived antigens presented on MR1. Upon TCR triggering,...
Peptide exchange–competent class I MHC molecules produced in eukaryotic cells for rapid production of MHC multimers
Abstract Class I MHC peptide (MHC-Ip) multimers are well-established reagents that detect antigen-specific T cells. The classical method for production of MHC-Ip multimers begins wit...
Identifying molecular signatures underpinning treatment responses to novel therapeutics influencing COVID-19 outcomes
Abstract COVID-19 continues to present ongoing global health challenges driven by diverse immune responses and heterogeneous clinical outcomes. The ACCORD trial evaluated 3 investiga...
MiR-221-5p aggravates sepsis-induced myocardial injury by targeting neuropilin-1
Abstract Sepsis-induced cardiac dysfunction is a primary contributor to mortality, and microRNAs (miRNAs) are recognized as crucial mediators in sepsis pathogenesis. This study aims...
Correction to: p38 signaling enhances short-lived effector cell differentiation and weakens central memory CD8+ T-cell formation
Deficiency in circulating T cells in four core genotypes mice with <i>Sry</i> translocation
Abstract Sex differences exist in the immune responses to infections and in the prevalence and severity of autoimmune and allergic diseases. These sex differences may be caused by se...
Identification of a regulatory allosteric site in Arid5a unveils a therapeutic axis for systemic inflammation
Abstract Adenine-thymine (AT)-rich interactive domain-containing protein 5a (Arid5a) is an RNA-binding protein (RBP) that post-transcriptionally stabilizes mRNAs encoding proinflamma...
The CXCL10/CXCR3 axis drives actin remodeling to recruit CD4+ T cells to gut epithelium during transmissible gastroenteritis virus infection
Abstract The immune system initially protects hosts against viral pathogens, with chemokines guiding immune cell movement. However, their expression patterns and immune cell recruitm...
Sorting nexin 5 deficiency impairs MHC class II antigen presentation and inflammatory responses during tuberculosis
Abstract Tuberculosis (TB) remains one of the leading causes of death from a single infectious agent worldwide, yet the host pathways that regulate antigen presentation and lung infl...
Immunotherapy of malignant melanoma using T cell–activating microbeads
Abstract Metastatic disease is the prime cause of death from many malignancies. Due to the multiple different lesions and the increased aggressiveness of the cancer cells, metastatic...
IL-17–driven transcriptional programs in muscle fibroblasts are not required for pathogenesis in murine anti-histidyl-tRNA synthetase (Jo-1) myositis
Abstract Idiopathic inflammatory myopathy (IIM) is a systemic autoimmune disease targeting muscle and extramuscular organs, but the molecular mechanisms driving IIM pathogenesis rema...
Elastase and myeloperoxidase participate in neutrophil extracellular trap release stimulated by SARS-CoV-2
Abstract COVID-19 is a disease triggered by SARS-CoV-2 and some individuals develop a severe form that can progress to multiple organ failure. Neutrophils have been described as resp...