The Journal of Immunology
Articles in this Issue
An MR1-specific nanobody capable of blocking MR1T cell activation
Abstract MR1 is a non-polymorphic, ubiquitously expressed, MHC class I-like antigen-presenting molecule that presents small-molecule metabolites to T cells. Studies have shown that M...
Disease progression is associated with differential neutrophil maturation in <i>Mycobacterium tuberculosis</i> –infected macaques
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is associated with clinical diversity and outcomes ranging from latent TB to active TB with distinct pathophys...
Metabolic adaptations of inflammatory macrophages govern ferroptosis susceptibility via the GCH1–BH4–iNOS axis
Abstract In inflammatory tissue niches, macrophages encounter intense oxidative stress due to their own production of reactive oxygen and nitrogen species as part of antimicrobial de...
Sleep interruption aggravates sepsis by rewiring the macrophage immune response
Abstract Sepsis is the leading cause of death in hospitals and is very common in intensive care units (ICUs). Sleep is frequently interrupted in the hospital setting, especially with...
Human XIRP1 is a new podosome protein targeting cytosolic bacteria as part of the IFN-γ defense program
Abstract Interferon-gamma (IFN-γ) is a powerful transactivating signal eliciting hundreds of IFN-stimulated genes (ISGs) in humans to help combat infection. Most ISGs remain uncharac...
Distinguishing Th17 cells as a unique subset
FTR85 negatively regulates type I IFN antiviral signaling pathway by promoting K48-linked polyubiquitination of IRF3
Abstract The finTRIM (FTR) subfamily, a group of fish-specific tripartite motif proteins, has arisen through gene duplication events specific to particular genera or species. However...
p120-catenin enhances macrophage efferocytosis and facilitates resolution of lung inflammatory injury
Abstract Defective resolution of inflammation following sepsis contributes to persistent immune dysfunction and increased morbidity and mortality worldwide. Efficient clearance of ap...
Variable fab domain N-glycosylation patterns in the B cell receptor repertoires of healthy individuals and patients with rheumatoid arthritis
Abstract N-linked glycosylation (N-glyc) sites (N-X-S/T, X≠P) can be introduced by somatic hypermutation in immunoglobulin Fab regions. In patients with rheumatoid arthritis (RA), an...
ENPP1-dependent USP2 ubiquitination governs SQSTM1-mediated autophagy-dependent ferroptosis in trophoblast cells and exacerbates placental dysfunction in gestational diabetes mellitus
Abstract Downregulation of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) has been implicated in autophagic cell death. However, how ENPP1 regulates the interplay between...
The V158F polymorphism in human FcγRIIIa/CD16a defines opposing receptor responses when interacting with soluble immune complexes
Abstract The V158F polymorphism found in the human Fc receptor CD16a (also known as FcγRIIIa) is thought to influence autoimmune disorders and responses to IgG-based therapies. V158F...
Incorporation of multiple diversity genes in the TCRδ chain is highly regulated and evolutionarily conserved
Abstract In the canonical model of VDJ recombination, a single diversity (D) gene is incorporated into the complementarity-determining region 3 (CDR3) to produce a T cell receptor δ...
CCR6-CCL20 signaling modulates immunoglobulin isotype switching at the mucosal barrier during gut inflammation
Abstract Chemokine CCL20, secreted by gut epithelial cells, demonstrates markedly increased expression during episodes of chronic inflammation and infection. Mucosal barriers recruit...
Comment on “Toward clinically actionable explainable AI in pulmonary arterial hypertension: Endpoints, calibration, and external validation”
A novel monocyte-derived antigen presenting cell-T regulatory cell axis contributes to skin wound healing and is impaired in diabetic mice
Abstract Despite a vast literature on the role of macrophages in wound healing, the role of dermal monocyte (Mo)-derived antigen presenting cells (APC) has received scant attention....
Fate mapping reveals a prenatal-to-neonatal wave of ILC2s with a history of <i>Cd3g</i> expression
Abstract Group 2 innate lymphoid cells (ILC2s) are thought to develop in the bone marrow and fetal liver. However, increasing evidence supports the presence of thymic ILC2s in mice a...
Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment (TME) in which cancer-associated fibroblasts (CAFs) play pivotal role...
Sustained antigen-specific CD8+ T cell immunity post–mRNA booster requires notch pathway activation
Abstract Messenger RNA (mRNA) vaccines effectively induce protective immunity, but antigen-specific CD8+ T cell responses exhibit limited persistence. In this study, we aimed to asse...
Differential stem-like potential of naïve and memory CD8 T cells after chronic infection
Abstract Memory CD8 T cells respond rapidly upon antigen re-encounter and are considered advantageous for protective immunity. However, they undergo a swift decline under chronic ant...
Distinct immune trajectories after severe trauma identify a Th17-biased immunophenotype in chronic critical illness
Abstract Severe trauma triggers a dynamic disturbance of immune function that can progress from early hyperinflammation to prolonged dysregulation, increasing patient vulnerability t...
Adjuvants orchestrate cross-organ induction of mucosal CD8+ T cell immune responses in respiratory tracts
Abstract Mucosal immunity is paramount for combating respiratory infections, but conventional vaccination methods, such as intramuscular injection, often struggle to induce it. Altho...
Inflammatory genital strain of <i>Chlamydia trachomatis</i> elicits a Th17 immune response
Abstract In humans, infection with Chlamydia trachomatis can result in chronic infection with severe reproductive consequences. The immune response elicited by natural infection fail...
Epigenetic control of p53 activity in regulatory T cells maintains their identity to prevent inflammation
Abstract Regulatory T cells (Tregs) are critical guardians of immune homeostasis that must operate in diverse and often inflammatory conditions. However, the mechanisms that Tregs us...
Genetic deletion of the inflammatory bowel disease-associated risk gene Rgs14 aggravates experimental colitis
Abstract Regulators of G protein signaling (RGS) deactivate G proteins associated with G protein-coupled receptors (GPCRs), a large receptor family with diverse functions. Of the 20...
IFITM1 differentially regulates antibacterial immunity and immunopathology but is dispensable for antiparasitic responses
Abstract Interferon-induced transmembrane (IFITM) proteins underpin antiviral responses, yet their role in bacterial infections remains underexplored, particularly for parasites. We...