The Journal of Immunology
Articles in this Issue
Correction to: ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism
ER stress amplifies inflammation via a dual mechanism involving IκBζ–XBP1s synergism and Regnase-1 degradation
Abstract Inflammatory diseases arise from complex interactions between immune signaling and cellular stress. Although endoplasmic reticulum (ER) stress is a key modulator of immunity...
Correction to: STING agonists drive recruitment and intrinsic type I interferon responses in monocytic lineage cells for optimal anti-tumor immunity
CSF1R-dependent macrophages control B cell development and function in the chicken immune system
Abstract Acquired immunity in mammals depends upon capture and presentation of antigens by specialized macrophage populations in splenic marginal zone and lymph node sinuses and foll...
Getting on your last nerve: IFNs and resistance to infection
Abstract Interferons (IFNs) affect almost all nucleated cells and induce transcriptional events that are associated with control of intracellular infections as well as regulatory pat...
The scaffolding protein AKAP79/150 shapes innate immune responses to allergen
Abstract Inhalation of house dust mite-derived allergens is a major factor leading to the development of asthma both in children and adults. Allergens stimulate Ca2+-dependent pro-in...
Optineurin restrains IL-17–associated neuroinflammation in trigeminal ganglia to preserve sensory function after ocular HSV-1 infection
Abstract Neurotrophic keratitis (NK) arises when trigeminal sensory dysfunction reduces corneal sensation and compromises epithelial maintenance. Herpes simplex virus type 1 (HSV-1)...
Reply: “Toward a more translational SS-ILD model: Sex differences, endpoints, and B cell targets”
Inhba is transcriptionally regulated by Foxa1 through the PI3K/AKT signal pathway in acute lung injury
Abstract Acute lung injury (ALI) is a fulminant respiratory failure syndrome with no targeted therapy. We show that Inhba is sharply upregulated in the damaged lung tissue of mice an...
Complement C3 deficiency increases the effector and cytotoxic functions of NK cells and suppresses tumor growth
Abstract The complement system and natural killer (NK) cells play crucial roles in tumor growth and metastasis. The role of the complement system in affecting the phenotype and anti-...
Single-cell profiling of immune activation, dysregulation, and reconstitution in rhesus macaques after measles virus infection
Abstract Protective immunity is induced by both, wild-type measles virus (WT MeV) and live-attenuated (LA) measles virus vaccine (LAMV), affording the opportunity to compare common a...
Compensatory relationships determine the impact of TGF-β on the humoral immune response to hepatitis B surface antigen
Abstract Despite an effective vaccine against the hepatitis B virus (HBV), there are about 250 million people living with chronic HBV (CHB) worldwide and one million deaths annually....
CRISPRi screening identifies SON and MAP4K1 as regulators of type III cytokine expression in innate lymphoid cells
Abstract The cytokines interleukin (IL)-22 and IL-17 are secreted by innate and adaptive immune cells to drive “type III” responses that protect against extracellular pathogens, prom...
MHC class II on melanoma cells regulates the anti-tumor T cell response
Abstract In human melanoma, tumor cell-specific MHC class II expression is associated with improved response to programmed death 1 and programmed death-ligand 1 blockade; yet the dir...
Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs
Abstract Foxp3+ regulatory T cells (Tregs) are capable suppressors of aberrant self-reactivity. However, how differences in affinity and specificity may support Treg function compare...
BPTF is essential for vaccine-induced germinal center B cell responses
Abstract Germinal centers (GCs) are microanatomical structures in which antigen-specific B cells undergo proliferation, somatic hypermutation, and affinity-based competition to selec...
TGF-β controls developmental fate and functional identity of thymic γδ T cells
Abstract Gamma delta (γδ) T cells undergo a distinct developmental pathway within the thymus, where transforming growth factor β (TGF-β) exerts pivotal regulatory influence. However,...
BACH1 orchestrates macrophage state transitions to coordinate regenerative inflammation
Abstract Efficient tissue regeneration requires the precise coordination of inflammatory and regenerative programs, principally mediated by monocyte-derived macrophages. However, the...
MAPK-activated protein kinase 2 orchestrates memory T-cell inflation in cytomegalovirus infection
Abstract Memory T-cell inflation is a distinctive immunological phenomenon observed during persistent viral infections such as cytomegalovirus (CMV). Unlike conventional memory T-cel...