The Journal of Immunology
Articles in this Issue
NKp44 recognition of platelet-derived growth factor D enhances the cytolytic activity of natural killer cells
Abstract Natural killer (NK) cells are cytotoxic innate lymphoid cells that play a critical role in tumor surveillance by releasing proinflammatory cytokines and cytotoxic granules....
Modeling pathogenic B cell function in experimental autoimmune encephalomyelitis
Abstract Success of B cell depletion therapy in multiple sclerosis (MS), an immune-mediated demyelinating disease of the central nervous system, places B cells and their functions ce...
Hidden effects of polymyxin B: Its role in activating TLR2-mediated inflammatory responses
Abstract Polymyxins are cyclic cationic lipopeptide antibiotics that disrupt both the outer and inner membranes of Gram-negative bacteria. They also bind to bacterial lipopolysacchar...
Phylogenetic analysis of amino acid sequences indicates a central role of transmembrane domain structural elements in MHC class II function
Abstract Human leukocyte antigen class II genes are highly polymorphic. This raises the question of how polymorphisms are distributed across the entirety of the class II molecule and...
NAD+ depletion links metabolic stress to drive innate immune priming and selectively control PANoptosis
Abstract The innate immune system can detect infection, tissue damage, and other homeostatic disruptions to initiate an immune response, drive inflammation, and promote programmed ce...
CD153 promotes B-cell responses to immunization in aged mice
Abstract We and others have described homeostatic dysregulation of the CD4+ memory T-cell compartment with age. To gain greater insights into this dysregulation, we performed compreh...
The transcription factor SREBP2 supports the activation and homeostasis of CD4+ Foxp3+ regulatory T cells
Abstract Periodic activation of regulatory T cells (Tregs) is necessary to restrict autoreactive T cells and maintain immune homeostasis. IL-2–STAT5 signaling instructs several metab...
Long-term survivors of melanoma after anti–PD-1 therapy demonstrate on-treatment increase in abundance of 4-1BB+ CD4 T cells in blood
Abstract Anti–PD-1 monotherapy has shown a significant survival benefit for patients with advanced-stage melanoma. In this study, we explored whether long-term clinical benefit is de...
The discovery and roles of type 2 innate lymphoid cells
Whole-body irradiation causes long-term impairments in the maintenance and function of naïve CD4 T cells specific for self- and non-self-antigens
Abstract Whole-body irradiation (WBI) consistently induces radiation-associated lymphopenia, a complication linked to poor prognosis and reduced overall survival. Understanding the q...
Split immunomodulatory impact of leptin on human myeloid cells: key role of IDO1 in counteracting the immunostimulatory effect of leptin
Abstract Obesity increases cancer incidence and aggressiveness but is paradoxically associated with improved response to immunotherapy. Here, we show that intratumoral levels of lept...
A mutation in <i>PTPN6</i> associated to emphysema alters B-lymphocyte biology in humans and mice
Abstract Our group discovered a mutation in a French-Canadian family causing a severe and early-onset form of emphysema. The heterozygote mutation located in the PTPN6 gene causes an...
Rag1-based time-stamp tracing of T-cell developmental origins
Abstract The postnatal T‑cell pool comprises cells at diverse developmental stages, complicating efforts to resolve T‑cell differentiation, maturation, and long‑term adaptation. To a...
IL-22 synergizes with IL-17 to promote mucosal inflammation and bone loss
Abstract Interleukin (IL)-22 mediates immune cell communication with nonhematopoietic cells and was shown to exert protective or destructive effects in different disease contexts. In...
FcγRIII blockade prevents anti-HLA–mediated platelet clearance in a humanized murine model of platelet transfusion refractoriness
Abstract Immune platelet transfusion refractoriness (iPTR) is a major complication in transfusion medicine. Although anti-HLA antibodies are recognized contributors, the mechanisms b...
Platelets are essential for survival of respiratory-restricted viral infection
Abstract Platelets are small, anucleate cells derived from megakaryocytes and are known for their essential role in hemostasis. Over the past decade, they have also emerged as import...
Systemic and lung-resident memory elicited by OC43 coronavirus infection in mice
Abstract Endemic coronaviruses circulate seasonally and, while typically mild, can produce robust inflammation and severe pneumonia. Immunological memory to coronaviruses can be cros...
Immunosuppressive effects of voclosporin in inflammatory bowel disease through targeted inhibition of SLP-76 and metabolic reprogramming
Abstract The adaptor protein SLP-76 plays a critical role in T-cell receptor signaling and immune activation, yet its relevance in inflammatory bowel disease (IBD) remains unclear. A...
Single-cell analysis of ovarian immune cells reveals dynamic changes in NK and B-cell populations after ovarian stimulation
Abstract The mammalian ovary is the dynamic end-organ of the hypothalamic–pituitary–ovarian axis. In this coordinated system, ovarian cells undergo continuous cycles of apoptosis, pr...
Toll-like receptor responses are shaped by distinct MAPK activation profiles
Abstract Toll-like receptors (TLRs) are key sensors of infection and injury, and are critical inducers of inflammation. TLR-induced activation of the NF-κB and MAPK pathways promotes...
Distinct kinetic features of innate and adaptive responses in influenza A versus influenza B–infected mice
Abstract Influenza B infection is an important source of morbidity and mortality, especially in vulnerable populations such as children. Improved vaccines and antiviral therapeutics...
T cell immunity to SARS-CoV-2 vaccination in inflammatory bowel disease patients treated with anti-cytokine biologics
Abstract Anti-TNF and anti-IL-12/IL-23 are commonly used therapies for immune-mediated inflammatory diseases (IMIDs), including inflammatory bowel disease (IBD). Although several stu...
CD22 is upregulated and displays suppressive properties on CD4+ T cells upon a persistent virus infection
Abstract Chronic viral infections evade or suppress host immunity, posing risks to global human health. However, the underlying mechanisms of viral immune suppression are incompletel...
Unconventional functions of natural killer cells in homeostasis and disease
Abstract NK cells are classically defined by their rapid cytotoxicity against tumor cells and infected cells and by early inflammatory cytokine production. However, unconventional ro...
Fluorescence tracking CD8 T cells from tumor-draining lymph nodes to irradiated tumors and their activation in the tumor environment
Abstract Radiation is an effective site-specific cytotoxic therapy for cancer cells. In preclinical models, CD8 T cells are essential for optimum tumor control by radiation therapy,...