The Journal of Immunology

Gut microbial composition modulates endogenous food-specific CD4+ T cells in food allergy

Alexa R Weingarden, Flannery S Dahlberg, Caroline N Broude et al. Jul 10, 2026 10.1093/jimmun/vkag172

Abstract The growing food allergy epidemic is thought to be related to changing environmental factors, particularly changes in the gut microbiome. While prior work has demonstrated t...

Lowering CD40L expression in murine lupus results in an increase in disease indicators in female but not male B6 mice

Diego Prado De Maio, Sandra Tetteh, Christopher Ayers et al. Jul 10, 2026 10.1093/jimmun/vkag205

Abstract Our laboratory has previously described a mouse model (CD40LΔ5) that produces 60% of wild-type CD40L due to a targeted deletion in an RNA binding site within the CD40L messa...

CD8+ T-cell effector programming is epigenetically regulated by DUSP2 through BAF complex–driven chromatin remodeling

Emilia R Dellacecca, Jacob B Hirdler, Whitney Barham et al. Jul 10, 2026 10.1093/jimmun/vkag202

Abstract Effector gene expression in CD8+ T cells is tightly controlled at the epigenetic and transcriptional levels; however, crucial regulatory signals remain incompletely understo...

T-cell miR-155 regulates the response to tumor-specific mRNA vaccines in a murine model of acute myeloid leukemia

Benjamin Battistone, Arevik Ghazaryan, William W Tang et al. Jul 10, 2026 10.1093/jimmun/vkag184

Abstract Acute myeloid leukemia (AML) is a malignant clonal expansion of myeloid progenitor cells that impedes normal hematopoiesis and culminates in bone marrow failure and death. T...

PARI deficiency leads to increased somatic hypermutation

Kevin Kalweit, Erik Jäger, Torsten Kroll et al. Jul 10, 2026 10.1093/jimmun/vkag031

Abstract Somatic hypermutation of immunoglobulin (Ig) genes in germinal center B cells is based on the introduction of DNA lesions by activation-induced cytidine deaminase (AID), fol...

Donor cell GATA3 is critical for gut pathogenic T cell effector function and intestinal eosinophilia after hematopoietic cell transplantation

Franklin J Yeo, Mengbo Wang, Sungtae Park et al. Jul 10, 2026 10.1093/jimmun/vkag190

Abstract Hematopoietic cell transplantation (HCT) is a curative immunotherapy for hematologic malignancies such as acute myeloid leukemia, primarily through graft-versus-tumor (GVT)...

Kaempferol’s potential in targeting IL-17–mediated inflammatory pathways for colorectal cancer treatment

Lu Ye, Mengjie Yu, Huilin Liu Jul 10, 2026 10.1093/jimmun/vkag176

Abstract Colorectal cancer (CRC) is a leading malignancy with limited treatment options at advanced stages. Interleukin (IL)-17 signaling promotes tumor progression and immune evasio...

mTECs and B cells form a thymic microniche associated with B-cell licensing

Ryan J Martinez, Adrianna M Rivera-León, Avrora Nikolaeva et al. Jul 10, 2026 10.1093/jimmun/vkag185

Abstract Thymic B cells rely on T cells and type-III IFN (IFN-λ) signaling for class switch recombination and effective licensing as APCs, a process essential for their role in estab...

A novel Vδ1 engager targeting CD19 enhances human Vδ1 γδ T cell responses against CLL and CD19+ hematological malignancies

Shefali A Bhumbra, Robert Good, Antara Banerjee et al. Jul 10, 2026 10.1093/jimmun/vkag167

Abstract γδ T cells are associated with favorable outcomes in many cancers likely through a mechanism of stress-directed cytotoxicity and antitumor cytokine production. Vδ1 γδ T cell...

Binding of death receptor 3 (DR3) to intracellular TRADD and TRAF2 is independent of its natural ligand, TL1A

Weiyong Sun, Bryce G Johnson, Praveen K Veerasubramanian et al. Jul 10, 2026 10.1093/jimmun/vkag194

Abstract The TNF‑like cytokine TL1A is a key regulator of immune responses through engagement of its receptor, death receptor 3 (DR3), and has emerged as a therapeutic target in infl...