Journal of Clinical Oncology
Articles in this Issue
Machine learning-based ICU mortality prediction across hematologic malignancy subtypes: A comparative analysis using MIMIC-IV.
262 Background: Patients with hematologic malignancies face high ICU mortality, yet prediction models largely treat these...
Tumor NK ligand profiles as predictors of allogenic NK cell therapy responsiveness.
80 Background: Although NK cells offer a versatile and safe therapeutic platform, the understanding of natural killer (NK)...
TGFβ-mediated overexpression of podoplanin serves as a potential diagnostic biomarker in acute promyelocytic leukemia.
264 Background: Early diagnosis of acute promyelocytic leukemia (APL), driven by PMLRARA oncoprotein, is vital for surviva...
Admission-day predictors of terminal outcome in advanced cancer inpatients: Insights from a large Indian palliative care cohort.
339 Background: Inpatient mortality in palliative care units ranges 10-30% globally, yet prognostic data from low- and mid...
Yttrium-90 resin microsphere transarterial radioembolization in unresectable hepatocellular carcinoma: Early results with scout dose–based lung shunt estimation and dosimetry.
155 Background: Yttrium-90 TARE is an effective locoregional therapy for HCC. TARE traditionally requires 99mTc-MAA for lu...
Hepatic arterial infusion chemotherapy combined with camrelizumab and lenvatinib in the treatment of advanced hepatocellular carcinoma: A retrospective study.
98 Background: PD-1 inhibitors combined with tyrosine kinase inhibitors have achieved encouraging efficacy in unresectable...
A novel oncolytic vaccinia virus armed with IL-21 and 4-1BBL for intravesical treatment of NMIBC: Preclinical efficacy and first-in-human safety evaluation.
198 Background: Oncolytic viruses are emerging cancer immunotherapies. For non–muscle-invasive bladder cancer (NMIBC), int...
Quantitative hazard visualization of radioisotope contamination risks in emergency settings following radium-223 therapy.
323 Background: Radium-223 (Ra-223), an alpha-emitting radiopharmaceutical, is a cornerstone of modern theranostics. While...
Long-term neoadjuvant chemoradiotherapy combined with camrelizumab for locally advanced rectal cancer: A single-arm, prospective, phase II clinical study.
93 Background: Neoadjuvant chemoradiotherapy (nCRT) has brought out a higher rate of complete response and anal sphincter...
MicroRNA-197-3p to counteract chemoresistance in ovarian cancer via COL4A6 inhibition.
221 Background: Collagen type IV alpha 6 (COL4A6) is overexpressed in ovarian cancer, where its elevated levels contribute...
Fruquintinib versus trifluridine-tipiracil plus bevacizumab versus regorafenib in refractory metastatic colorectal cancer: A propensity score–matched real-world analysis.
134 Background: Fruquintinib, trifluridine-tipiracil plus bevacizumab (FTD/TPI+bev), and regorafenib are approved for refr...
Identification of independent prognostic factors in relapsed pediatric B-ALL patients receiving CD19 CAR-T without consolidative HSCT.
249 Background: After CD19 chimeric antigen receptor (CAR) T-cell therapy (CAR-T), some B cell acute lymphoblastic leukemi...
Patient-reported outcomes for effective screening of chemotherapy-induced peripheral neuropathy.
350 Background: Effective toxicity screening is necessary to improve cancer care. Chemotherapy-induced peripheral neuropat...
Shared tumor-reactive T cell clonotypes from tumor-infiltrating lymphocytes and tumor-associated lymph nodes defined by single-cell sequencing and tumor organoid models in non-small cell lung cancer.
275 Background: Tumor-infiltrating lymphocytes (TILs) are a critical subset of immune cells in solid tumors, particularly...
Integrated fragmentomics and droplet digital PCR–based methylation analysis of cell-free DNA for enhanced detection of precancerous lesions and early colorectal cancer.
95 Background: Early detection of colorectal cancer (CRC), particularly at the precancerous stage, is essential for reduci...
New and more drugs for early-stage cancers: Have they translated to more cures?
317 Background: The U.S. Food and Drug Administration (FDA) oversees cancer drug approvals in the United States but has an...
BRIGHT-Fe: A phase III randomized trial of intravenous ferric derisomaltose vs low-dose oral iron polypeptide in iron-deficient early breast cancer receiving (neo)adjuvant chemotherapy.
TPS66 Background: Iron deficiency anemia (IDA) is common in early breast cancer (EBC) patients receiving (neo)adjuvant che...
Site-specific conjugation of PEG12-PSMA ligand to dianthin by click chemistry to kill prostate cancer cells in the presence of the endosomal escape enhancer SO1861.
179 Background: Prostate-specific membrane antigen (PSMA) is overexpressed in many prostate cancer cells and is a promisin...
Effect of long-limb Roux-en-Y reconstruction on early glycemic control compared with Billroth II after subtotal gastrectomy in patients with type 2 diabetes and gastric cancer: 6-Month interim analysis of the STARDOM trial.
157 Background: Gastrectomy can induce improvement in type 2 diabetes (T2DM), yet the metabolic impact may vary according...
Analytical cross-sectional study of correlation between plasma D-dimer levels and lymphovascular invasion in operable carcinoma breast.
64 Background: Malignancy is frequently associated with a hypercoagulable state due to tumour-induced activation of coagul...
Real-world comparative safety of first-line lorlatinib versus alectinib in metastatic ALK-rearranged non-small cell lung cancer: A propensity score-matched analysis.
283 Background: Lorlatinib and alectinib are both NCCN-preferred first-line therapies for ALK-positive metastatic NSCLC, y...
Circulating tumor cell-based molecular classification to reveal heterogenous subclones in gestational trophoblastic neoplasia.
222 Background: Gestational trophoblastic neoplasia (GTN) is caused by cancerous transformation of placental trophoblastic...
Hepatic arterial infusion chemotherapy combined with transcatheter chemoembolization, camrelizumab, and apatinib for hepatocellular carcinoma with portal vein tumor thrombosis: A retrospective study.
301 Background: This study evaluated the combination of hepatic arterial infusion chemotherapy (HAIC), transcatheter chemo...
Unmet needs, quality of life, and lived experiences of patients with metastatic breast cancer in central Viet Nam: A convergent mixed-methods study.
56 Background: Metastatic breast cancer (mBC) imposes a significant burden in lower-middle-income countries, yet data on t...
Transformer-based multi-omics synthesis for early risk stratification and preventive surveillance in liver oncology.
10 Background: The efficacy of early intervention in liver oncology is frequently compromised by the profound molecular he...