Journal of Clinical Oncology
Articles in this Issue
Survivorship care planning and psychosocial outcomes in cervical cancer caregivers.
214 Background: Survival in Cervical Cancer has improved substantially, increasing reliance on informal caregivers through...
Comparative effectiveness of different interventions in metastatic melanoma: A network meta-analysis.
294 Background: Multiple therapeutic options are available for metastatic melanoma, including immune checkpoint in...
Tislelizumab in combination with carboplatin and albumin–binding paclitaxel for neoadjuvant therapy in head and neck squamous cell carcinoma: A prospective, phase II clinical study.
226 Background: Surgery followed by adjuvant therapy remains the standard treatment for locally advanced head and neck squ...
Evaluating a hybrid AI-powered digital health guide to improve informed decision making and streamline access to genetic testing for hereditary cancer.
319 Background: Despite expanded testing guidelines, lower costs, and clear clinical utility, uptake of genetic testing re...
Long-term outcomes and patterns of recurrence in mucinous rectal adenocarcinoma: A KCRG multicenter study.
123 Background: Mucinous adenocarcinoma is a poor prognostic indicator of colorectal cancer. Due to its rarity, mucinous c...
Doxycycline modulation of the CD39/CD73–adenosine axis to enhance CD8⁺ T cell and M1 macrophage immunity in patient-derived breast cancer samples.
33 Background: The CD39/CD73–adenosine axis functions as a metabolic immune checkpoint in breast cancer by converting extr...
Characterizing plasma circulating tumor RNA (ctRNA) landscape in advanced NSCLC: Preliminary insights into treatment resistance and tumor microenvironment.
167 Background: Plasma circulating tumor RNA (ctRNA) is currently used for gene fusion detection in non–small cell lung ca...
Disease-specific safety risks in oncology large language models: A multi-axis evaluation across solid tumor subtypes.
19 Background: Large language models (LLMs) are increasingly explored for oncology clinical decision support; however, saf...
Simulating expert oncologist-to-oncologist thinking and behavior: Multi-agent AI for precision oncology collaboration.
20 Background: Collaborative oncologist decision-making—via tumor boards, subspecialty consultation, and second opinions—f...
Comparative efficacy and safety of first-line maintenance therapies in advanced ovarian cancer: A biomarker-stratified Bayesian network meta-analysis of 16 phase 3 trials.
213 Background: The integration of poly(ADP-ribose) polymerase inhibitors (PARPi), immune checkpoint inhibitors (ICI), and...
Mortality trends and disparities in bone-metastatic prostate cancer in the United States, 1999–2024: A CDC WONDER analysis.
189 Background: In United States, mortality trends for bone-metastatic prostate cancer remain incompletely characterized....
INAVO120 phase 3 trial: Subgroup analyses of Asian patients (pts) with <i>PIK3CA</i> -mutated (mut), hormone receptor-positive, HER2-negative (HER2–), endocrine-resistant advanced breast cancer (aBC) treated with inavolisib (INAVO)/placebo (PBO) + palbociclib (PALBO) + fulvestrant (FULV).
28 Background: INAVO is an oral, highly potent, and selective PI3Kα inhibitor that also promotes mut p110α degradation. In...
Real-world artificial intelligence use in oncology practice: High clinician verification amid critical governance gaps.
353 Background: Artificial intelligence (AI) tools are rapidly entering oncology practice. However, real-world data descri...
Testosterone deprivation or androgen receptor inhibition effect on endothelial glycocalyx injury in prostate cancer.
193 Background: Endothelial glycocalyx, which coats the luminal surface of vascular endothelial cells, plays a pivotal rol...
CAR-NK cell therapy in colorectal cancer: A systematic review of early clinical signals and translational strategies.
79 Background: Colorectal cancer (CRC) demonstrates limited responsiveness to current immune checkpoint inhibitors...
Clinicopathologic features, treatment patterns, and survival outcomes of glycogen-rich clear cell carcinoma of the breast: A National Cancer Database Analysis.
40 Background: Glycogen-rich clear cell carcinoma (GRCC) of the breast is rare subtype of invasive breast carcinoma, chara...
Hallmarks based stratification of locally advanced GBC according to response to first-line chemotherapy in advanced gallbladder cancer (GBC).
309 Background: GBC is a heterogenous disease with high mortality rate. While platinum-based chemotherapy remains the SOC...
Decision-making in cancer during pregnancy: Real-world management patterns and outcomes from Nepal.
302 Background: Cancer occurring one in every 1,000 pregnancies is rare and poses immense diagnostic and management challe...
Health related quality of life (HRQOL) and early clinical outcomes of high - very high risk prostate cancer treated with linac based stereotactic body radiotherapy (SBRT) and long term androgen deprivation therapy (ADT).
191 Background: Stereotactic body radiotherapy (SBRT) in NCCN high-risk (HR) and very high-risk (VHR) prostate cancer is e...
Adebrelimab plus interventional and targeted therapy for unresectable hepatocellular carcinoma: A single-arm, real-world study.
107 Background: Systemic therapy with immune checkpoint inhibitors (ICIs) and targeted agents, in combination with interve...
Neoadjuvant toripalimab combined with TIP chemotherapy for locally advanced penile squamous cell carcinoma: A multicenter prospective, single-arm, phase II clinical trial.
178 Background: The neoadjuvant regimen of paclitaxel, ifosfamide, and platinum (TIP) regimen is recommended for local adv...
Adebrelimab plus apatinib for maintenance treatment of extensive-stage small cell lung cancer after first-line induction with adebrelimab plus chemotherapy (CLOG2402-ADAPT): A multi-center, single-arm, phase II trial.
271 Background: Immune checkpoint inhibitors (PD-1/PD-L1) combined with chemotherapy have become the standard first-line t...
Implementation of a patient-reported symptom tool in low-resource settings with high demand for services: A pilot feasibility study (PROMISE-Pilot).
352 Background: Patients often experience cancer and treatment-related symptoms that can be under-elicited and under-repor...
Strengthening nurse-led clinical breast examination (CBE) screening through quality improvement: A prospective implementation study from a tertiary hospital in eastern India.
315 Background: India, representing nearly one-fifth of the global female population, faces a rapidly increasing breast ca...
Real-world incidence and spectrum of immune-related toxicity in cancer patients: A registry cohort data from a Central Coast Cancer Centre.
318 Background: Immune-checkpoint inhibitors (ICIs) have transformed outcomes across a broad range of solid malignancies,...