Journal of Clinical Oncology
Articles in this Issue
Postoperative ICU outcomes and predictors of morbidity and mortality in cancer patients after oncosurgery: A retrospective study from a tertiary care center in India.
345 Background: Surgery remains the cornerstone of curative treatment for many malignancies, yet, postoperative complicati...
From the outback to oncology suites : Redefining cancer care for rural and Aborginal Australians.
331 Background: For too long, an Aboriginal Australian's postcode has predicted their cancer outcome. In north-western New...
Camrelizumab plus rivoceranib as first-line maintenance therapy after camrelizumab-chemo induction in advanced esophageal squamous cell carcinoma: A prospective, single-arm, phase II clinical trial.
TPS158 Background: ESCORT-1st, a global phase III trial evaluating camrelizumab (Cam) plus paclitaxel and cisplatin (TP) a...
Efficacy and safety of intrathecal pemetrexed in the treatment of leptomeningeal metastases from ALK-mutant NSCLC: A prospective, multi-center, single-arm, phase II clinical trial.
265 Background: This study aimed to evaluate the efficacy and safety of intrathecal pemetrexed (IP) in the treatme...
Germline testing in pancreatic adenocarcinoma: A retrospective cohort study of germline genetic testing uptake, patterns of referral, clinical findings and impact in the South Western Sydney Local Health District.
115 Background: Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival <12%. Universal germline genetic testing...
Clinical and radiologic outcomes of immune checkpoint inhibitor therapy in cancer patients with pre-existing interstitial lung disease: A retrospective study from Vietnam.
343 Background: Patients with pre-existing interstitial lung disease (ILD) are frequently excluded from immune checkpoint...
AI as a clinical teaching co-pilot: A real-world evaluation of an LLM-integrated bedside microteaching model in inpatient oncology.
5 Background: Structured bedside teaching in inpatient oncology is increasingly displaced by service pressures, particular...
Association of tumor microenvironment landscape with neoadjuvant therapy resistance in hormone receptor–positive breast cancer.
37 Background: Hormone receptor (HR)–positive breast cancer shows limited sensitivity to neoadjuvant therapy, with pCR rat...
Comparative effectiveness of first-line pembrolizumab plus chemotherapy, nivolumab plus chemotherapy, and nivolumab plus ipilimumab in metastatic esophageal squamous cell carcinoma: A propensity score-matched real-world analysis.
135 Background: Pembrolizumab plus chemotherapy (KEYNOTE-590), nivolumab plus chemotherapy, and nivolumab plus ipilimumab...
Development of a multidimensional diagnostic model integrating cfDNA methylation and clinical parameters for colorectal cancer and precancerous lesions using artificial intelligence.
94 Background: Early detection of colorectal cancer (CRC) and precancerous lesions is critical for improving patient outco...
Short-course radiotherapy and chemotherapy with or without PD-L1 blockade (envafolimab) for MSS locally advanced rectal cancer: Interim analysis of the randomized phase III PRECAM-R trial.
92 Background: Microsatellite stable (MSS) locally advanced rectal cancer (LARC) is refractory to immune checkpoin...
Systemic immune-inflammation index as a prognostic biomarker across T-stage, biliary obstruction, and treatment setting in cholangiocarcinoma: A retrospective cohort study.
137 Background: Cholangiocarcinoma (CCA) carries a dismal prognosis, and low-cost biomarkers applicable across disease sta...
Machine learning-based prediction of ICU mortality in patients with pancreatic cancer: A MIMIC-IV retrospective cohort study.
142 Background: Pancreatic cancer patients requiring ICU admission face high short-term mortality, yet no disease-specific...
Learning from failure: A multifactorial analysis of locoregionally advanced laryngeal cancer (LALC) recurrence and the impact of a standardized SOP in a resource-limited setting.
231 Background: In low- and middle-income countries (LMICs), LALC prognosis is often compromised by treatment heterogeneit...
Structural determinants of diagnosis and prognosis in cervical cancer: Associations between care setting, comorbidity burden, and sociodemographic factors.
209 Background: Cervical cancer remains a significant public health issue, with approximately 13,000 new cases and over 4,...
Stage distribution and survival outcome in a real-world cervical cancer cohort from an urban-dominant population in Indonesia.
219 Background: Cervical cancer is the second most common female malignancy in Indonesia and remains one of the leading ca...
The AI–CDK4/6i synergy matrix: A de-novo meta-analysis decoupling aromatase-inhibitor identity from survival outcomes in 1L HR+/HER2− advanced breast cancer.
59 Background: Clinical guidelines currently treat letrozole (LET) and anastrozole (ANA) as interchangeable non-steroidal...
Real world outcomes with neoadjuvant chemo-immuno-metronomic therapy in advanced head and neck squamous cell carcinoma (NeoLOCUS-Retro).
236 Background: Patients with stage IVA–IVB head and neck squamous cell carcinoma (HNSCC) ineligible for upfront surgery o...
Assessing the clinical and biological associations between multimodal artificial intelligence (MMAI) and 22-gene genomic classifier (GC) in localized prostate cancer (PCa).
196 Background: MMAI and GC are clinically validated prognostic tools for localized PCa, and are incorporated into NCCN gu...
Consensus statement on ctDNA minimal residual disease (MRD) testing in early-stage NSCLC: A Delphi study by the Asian Thoracic Oncology Research Group (ATORG).
289 Background: Minimal residual disease (MRD) detection using liquid biopsy is an emerging tool for risk stratification a...
Tumor mutation profiles and circulating tumor DNA detection across gastrointestinal and hepatobiliary cancers.
127 Background: This study aimed to compare tumor mutation landscapes and ctDNA detection across 9 types of gastrointestin...
Histopathological and clinicoradiological correlation in esophageal neoplasm and 2-year institutional experience in minimally invasive surgery.
151 Background: Esophageal cancers, primarily esophageal adenocarcinoma and squamous cell carcinoma (SCC), present diverse...
Rapid and reversible endothelial glycocalyx injury during tyrosine kinase inhibitor therapy in locally advanced or metastatic renal cell carcinoma.
192 Background: Endothelial glycocalyx, which coats the luminal surface of vascular endothelial cells, plays a pivotal rol...
Genomic enrichment using Decipher and PAM50 luminal B to optimize neoadjuvant immunotherapy strategies in high-risk prostate cancer.
197 Background: Clinical risk tools incompletely capture biologic heterogeneity in prostate cancer (PCa), limiting enrichm...
Racial and ethnic disparities in hospital mortality among cancer patients admitted to the intensive care unit: A retrospective analysis of the MIMIC-IV database.
347 Background: Black patients with cancer face higher mortality rates than White patients across most malignancies, yet w...