Journal of Clinical Oncology
Articles in this Issue
Impact of nurse-initiated early telephone follow-up on unplanned 30-day hospital admissions after first-cycle chemotherapy: A real-world implementation study.
326 Background: Patients receiving chemotherapy may experience treatment-related side effects after discharge, particularl...
Heart failure–related mortality in patients with breast cancer: A 26-year national surveillance study (1999–2024).
43 Background: Heart failure (HF) is a recognized comorbidity in breast cancer patients, affecting both survival and quali...
Interaction of DLL3-targeting CAR-T cells with the JAK1 inhibitor in treating small cell lung cancer.
286 Background: Small cell lung cancer (SCLC) is an aggressive malignancy with limited effective treatment options. DLL3-t...
Real-world experience with second and third generation tyrosine kinase inhibitors in imatinib-resistant Nigerian patients with BCR::ABL1 positive chronic myeloid leukaemia.
255 Background: Imatinib significantly advances CML management, inducing deep molecular response and increasing survival....
TMEM132A to promote cervical cancer progression via HOMER3-mediated activation of FAK/PI3K/AKT signaling pathway.
223 Background: TMEM132A exhibits aberrant expression in various types of solid tumors. However, its biological roles and...
Surgical outcomes and recurrence risk factors for rectal gastrointestinal stromal tumors: A comparison of transabdominal and transanal resection.
114 Background: Rectal gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms that present unique surgical...
Efficacy of melatonin supplementation for sleep quality, depression, and fatigue in patients with breast cancer: A systematic review and meta-analysis.
55 Background: Breast cancer patients frequently experience a cluster of debilitating symptoms, including sleep disturbanc...
The prognostic significance of MYBL1 and MYBL2 genes in low-grade glioma.
73 Background: Low-grade gliomas (LGG) demonstrate heterogeneous clinical behavior despite shared histologic classificatio...
Artificial intelligence–assisted colonoscopy and adenoma detection: An updated systematic review and meta-analysis of 42 studies.
2 Background: Colonoscopy misses a meaningful proportion of adenomas, limiting preventive effectiveness. We updated the ev...
Prospective study of quantitative broadband diffuse optical spectroscopy for differential diagnosis of suspicious breast lesions.
31 Background: A definitive breast cancer diagnosis requires a biopsy. However, suspicious lesions classified BI-RADS 3 an...
Latent profiles of digital health technophobia and associated factors among older adults with cancer.
354 Background: As digital health technologies become increasingly embedded in oncology care, older adults with cancer are...
Tri-marker model integrating BCL2A1 expression in CD8⁺ T cells, PD-L1, and HOT score as a predictor of immune checkpoint blockade response in lung adenocarcinoma: A multi-cohort integrative analysis.
291 Background: Despite advances in immune checkpoint blockade (ICB) for advanced lung adenocarcinoma (LUAD), predictive b...
Real-world effectiveness and safety of amivantamab plus chemotherapy versus chemotherapy alone in EGFR-mutant NSCLC after osimertinib: A propensity score–matched analysis.
284 Background: Amivantamab plus carboplatin–pemetrexed was approved (Sep 2024) for EGFR-mutant advanced NSCLC post-osimer...
Translational advancement of HCB101, a third-generation SIRPα–Fc ligand trap targeting the CD47-SIRPα axis: Integrated phase 1 monotherapy and phase 1b/2a combination development.
TPS89 Background: The CD47–SIRPα axis functions as a central innate immune checkpoint that suppresses macrophage-mediated...
Psychosocial distress and health-related quality of life in women undergoing active treatment for breast and gynaecological cancers: A cross-sectional analysis.
330 Background: Despite advances in systemic therapy, psychosocial distress during active cancer treatment remains under-r...
RelB/ILF2–GM-CSF loop to sustain MDSC-mediated prostate cancer immunosuppression.
105 Background: Prostate cancer (PCa) is characterized by an immunologically “cold” tumor microenvironment (TME), with pro...
Early results from a phase 1/2 clinical study of a urine-based multi-cancer early detection (MCED) assay for prostate, bladder, and kidney cancers.
181 Background: Current diagnostic pathways for kidney, bladder and prostate cancers rely on invasive procedures and imagi...
Availability and reimbursement of systemic therapies for the five most common cancers in Vietnam: A national landscape analysis.
329 Background: Access to evidence-based systemic anticancer therapies remains uneven in many low- and middle-income count...
Adebrelimab combined with oral etoposide for older patients and patients with poor performance status In small cell lung cancer: A multicenter, open-label, phase II clinical study.
TPS293 Background: Small cell lung cancer (SCLC) is a highly aggressive, high-grade neuroendocrine carcinoma characterized...
Liver resection in a resource-limited setting: Outcome of developed-world standards of R0 resection and 30-day mortality without a dedicated ICU or advanced technology—A real-world data analysis from Sri Lanka.
344 Background: Liver resection with curative intent offers a chance of long-term survival for patients with hepatic malig...
Real-world outcomes of first-line afatinib in advanced non–small cell lung cancer patients with uncommon EGFR mutations at Vietnam National Cancer Hospital.
277 Background: Uncommon EGFR mutations represent a heterogeneous subgroup of non–small cell lung cancer (NSCLC) with vari...
Nimotuzumab combined with induction chemotherapy and concurrent chemoradiotherapy for locally advanced nasopharyngeal carcinoma: A prospective, multicenter, randomized controlled trial—Preliminary analysis.
238 Background: To evaluate nimotuzumab combined with standard chemoradiotherapy in locally advanced nasopharyngeal carcin...
Integrative immune-genomic profiling for identification of treatment-relevant phenotypes association with predicted sensitivity to neoadjuvant chemo-immunotherapy in muscle-invasive bladder cancer.
183 Background: Neoadjuvant chemo-immunotherapy is an emerging strategy for muscle-invasive bladder cancer (MIBC), yet res...
Comprehensive geriatric assessment to predict 30-day postoperative morbidity in elderly patients undergoing curative surgery for oral squamous cell carcinoma: A prospective observational study.
230 Background: Chronological age alone is an inadequate predictor of surgical outcomes in elderly patients with oral squa...
Single-cell atlas and the role of sex hormones and chromosomes in sex-divergent reprogramming of the tumor microenvironment.
174 Background: Sex bias is pervasive in tumors; however, the contributions of sex chromosomes and hormones to reprogrammi...